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High prevalence of chronic hepatitis D virus infection in Eastern Turkey: urbanization of the disease

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dc.contributor.authorDulger, Ahmet Cumhur
dc.contributor.authorSuvak, Burak
dc.contributor.authorGonullu, Hayriye
dc.contributor.authorGONULLU, Edip
dc.contributor.authorGultepe, BİLGE
dc.contributor.authorAydın, İbrahim
dc.contributor.authorBatur, Abdussamet
dc.contributor.authorKaradaş, Sevdegül
dc.contributor.authorOlmezi, Sehmus
dc.contributor.institutionauthorSÜMBÜL, BİLGE
dc.date.accessioned2019-10-05T13:28:48Z
dc.date.available2019-10-05T13:28:48Z
dc.date.issued2016-04-01
dc.description.abstractIntroduction: Both hepatitis B virus (HBV) and hepatitis D virus (HDV) infection play an increasingly important role in liver diseases. The main objective of this study was to investigate the socio-epidemiological, laboratory and radiological aspects of both HBV and HDV infection near the Iranian border of Turkey. Material and methods: The study included 3352 patients with HBV and HDV infection. Socioepidemiological, laboratory and radiological aspects of the study subjects were retrospectively examined. Comorbid metabolic diseases were not assessed due to the retrospective design of the study. Results: Most of the study subjects were HBe antigen negative. No significant difference in terms of HBV-DNA levels or HBe antigen seropositivity was detected between the city centre and rural areas (p > 0.005). The mean HBV-DNA level in the anti-HDV-positive group was significantly lower than in the anti-HDV-negative group (p < 0.001). The rate of HDV-RNA positivity in women was higher than in their male counterparts (p = 0.017). Anti-HDV-IgG was detected in 18.4% of tested subjects who came from an urban area. In contrast, 12.5% of subjects of the rural group had a positive result for anti-HDV-IgG. Among 134 ultrasonographically evaluated delta hepatitis patients, 37.3% had liver cirrhosis. On the other hand, in 1244 patients with hepatitis B monoinfection, there were 90 patients with liver cirrhosis. Radiologically, the rate of hepatic steatosis in delta hepatitis patients was lower than in those with HBV monoinfection. Conclusions: Hepatitis D virus infection was particularly prevalent among the urban population as well as in female subjects. More broadly, the current observations are the first to suggest an inverse correlation between delta hepatitis and ultrasonography-proven hepatic steatosis.en
dc.identifier10.1016/j.archger.2014.03.008
dc.identifier.citationDulger A. C. , Suvak B., Gonullu H., GONULLU E., Gultepe B., Aydın İ., Batur A., Karadaş S., Olmezi S., -High prevalence of chronic hepatitis D virus infection in Eastern Turkey: urbanization of the disease-, ARCHIVES OF MEDICAL SCIENCE, cilt.12, ss.415-420, 2016
dc.identifier.doi10.5114/aoms.2015.52030
dc.identifier.pubmed27186189
dc.identifier.scopus84963765689
dc.identifier.urihttps://hdl.handle.net/20.500.12645/2177
dc.identifier.wosWOS:000374510200024
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectChronic hepatitis D virus
dc.titleHigh prevalence of chronic hepatitis D virus infection in Eastern Turkey: urbanization of the disease
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameARCHIVES OF GERONTOLOGY AND GERIATRICS
local.avesis.id34be30a4-77d5-4649-9a3b-ea2ea60d16c9
local.avesis.response2047
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication51568f47-69f1-46a2-b201-e6d6161080a8
relation.isAuthorOfPublication.latestForDiscovery51568f47-69f1-46a2-b201-e6d6161080a8
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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