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Relationship between periodontal destruction and gene mutations in patients with familial Mediterranean fever

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dc.contributor.authorSezer, Ufuk
dc.contributor.authorŞENYURT, SÜLEYMAN ZİYA
dc.contributor.authorOzdemir, Eda Cetin
dc.contributor.authorZengin, Orhan
dc.contributor.authorÜSTÜN, KEMAL
dc.contributor.authorERCIYAS, KAMİLE
dc.contributor.authorKisacik, Bunyamin
dc.contributor.authorOnat, Ahmet Mesut
dc.date.accessioned2020-10-29T23:05:23Z
dc.date.available2020-10-29T23:05:23Z
dc.date.issued2016-07-01T00:00:00Z
dc.description.abstractRecent studies have shown that genetic factors involved in the host responses might determine the disease severity for both familial Mediterranean fever (FMF) and periodontitis. The present study aimed to investigate the relationship of FMF with periodontitis and to search for the potential association between periodontitis and MEFV gene missense variations in patients with FMF. The study consisted of 97 FMF patients and 34 healthy volunteers. FMF patients were classified according to the kind of MEFV gene mutation: (1) patients with homozygous M694V gene mutation, (2) patients with heterozygous M694V gene mutation, and (3) patients with MEFV gene different mutations. Gingival Index (GI), Plaque Index (PI), probing pocket depth (PD), and clinical attachment level (CAL) were measured in all participants. The results of multivariate logistic regression showed a highly significant association between homozygous M694V gene mutation and periodontitis in FMF patients (p < 0.05). After adjusting for potential confounders (smoking, body weight, age, and gender), FMF patients with homozygous M694V gene mutation were 3.51 (1.08-11.45) times more likely to present periodontitis than the other FMF patients. These results indicate that the presence of homozygous M694V gene mutation seems to increase the risk for periodontitis in FMF patients.
dc.identifier.citationSezer U., ŞENYURT S. Z. , Ozdemir E. C. , Zengin O., ÜSTÜN K., ERCIYAS K., Kisacik B., Onat A. M. , -Relationship between periodontal destruction and gene mutations in patients with familial Mediterranean fever-, CLINICAL RHEUMATOLOGY, cilt.35, ss.1841-1847, 2016
dc.identifier.doi10.1007/s10067-015-3078-8
dc.identifier.pubmed26400644
dc.identifier.scopus84944631052
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26892
dc.identifier.wosWOS:000379010900024
dc.titleRelationship between periodontal destruction and gene mutations in patients with familial Mediterranean fever
dc.typeArticle
dspace.entity.typePublication
local.avesis.idcf36f4c3-d3ac-41ab-9c9f-3473cbfb3c8c
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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