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Outcomes of high-risk breast lesions diagnosed using image-guided core needle biopsy: results from a multicenter retrospective study.

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dc.contributor.authorOktay, Ayşenur
dc.contributor.authorAslan, Özge
dc.contributor.authorTaşkın, Füsun
dc.contributor.authorTunçbilek, Nermin
dc.contributor.authorEsen İçten, Selma Gül
dc.contributor.authorBalcı, Pınar
dc.contributor.authorArıbal, Mustafa Erkin
dc.contributor.authorÇelik, Levent
dc.contributor.authorÖrgüç, İhsan Şebnem
dc.contributor.authorBaşaran Demirkazık, Figen
dc.contributor.authorGültekin, Serap
dc.contributor.authorAydın, Ayşe Murat
dc.contributor.authorDurmaz, Emel
dc.contributor.authorKul, Sibel
dc.contributor.authorBinokay, Figen
dc.contributor.authorÇetin, Meltem
dc.contributor.authorEmlik, Ganime Dilek
dc.contributor.authorAkpınar, Meltem Gülsün
dc.contributor.authorKadıoğlu Voyvoda, Sadiye Nuray
dc.contributor.authorPolat, Ahmet Veysel
dc.contributor.authorBaşara Akın, Işıl
dc.contributor.authorYıldız, Şeyma
dc.contributor.authorPoyraz, Necdet
dc.contributor.authorÖzsoy, Arzu
dc.contributor.authorÖztekin, Pelin Seher
dc.contributor.authorElverici, Eda
dc.contributor.authorBayrak, İlkay Koray
dc.contributor.authorİkizceli, Türkan
dc.contributor.authorDinç, Funda
dc.contributor.authorSezgin, Gülten
dc.contributor.authorGülşen, Gökçe
dc.contributor.authorTunçbilek, Işıl
dc.contributor.authorYalçın, Sabiha Rabia
dc.contributor.authorÇolakoğlu, Gül
dc.contributor.authorAğlamış, Serpil
dc.contributor.authorYılmaz, Ravza
dc.contributor.authorRona, Günay
dc.contributor.authorDurhan, Gamze
dc.contributor.authorGüner, Davut Can
dc.contributor.authorÇelik Yabul, Fatma
dc.contributor.authorGünbey Karabekmez, Leman
dc.contributor.authorTutar, Burçin
dc.contributor.authorGöktaş, Muhammet
dc.contributor.authorBuğdaycı, Onur
dc.contributor.authorSuner, Aslı
dc.contributor.authorÖzdemirhttps/Orcid Org/, Necmettin
dc.date.accessioned2023-05-16T14:32:07Z
dc.date.available2023-05-16T14:32:07Z
dc.date.issued2023-01-08T21:00:00Z
dc.description.abstractThe clinical management of high-risk lesions using image-guided biopsy is challenging. This study aimed to evaluate the rates at which such lesions were upgraded to malignancy and identify possible predictive factors for upgrading high-risk lesions.
dc.description.abstractThis retrospective multicenter analysis included 1.343 patients diagnosed with high-risk lesions using an image-guided core needle or vacuum-assisted biopsy (VAB). Only patients managed using an excisional biopsy or with at least one year of documented radiological follow-up were included. For each, the Breast Imaging Reporting and Data System (BI-RADS) category, number of samples, needle thickness, and lesion size were correlated with malignancy upgrade rates in different histologic subtypes. Pearson's chi-squared test, the Fisher-Freeman-Halton test, and Fisher's exact test were used for the statistical analyses.
dc.description.abstractThe overall upgrade rate was 20.6%, with the highest rates in the subtypes of intraductal papilloma (IP) with atypia (44.7%; 55/123), followed by atypical ductal hyperplasia (ADH) (38.4%; 144/375), lobular neoplasia (LN) (12.7%; 7/55), papilloma without atypia (9.4%; 58/611), flat epithelial atypia (FEA) (8.7%; 10/114), and radial scars (RSs) (4.6%; 3/65). There was a significant relationship between the upgrade rate and BI-RADS category, number of samples, and lesion size Lesion size was the most predictive factor for an upgrade in all subtypes.
dc.description.abstractADH and atypical IP showed considerable upgrade rates to malignancy, requiring surgical excision. The LN, IP without atypia, pure FEA, and RS subtypes showed lower malignancy rates when the BI-RADS category was lower and in smaller lesions that had been adequately sampled using VAB. After being discussed in a multidisciplinary meeting, these cases could be managed with follow-up instead of excision.
dc.identifier.pubmed36994925
dc.identifier.urihttps://hdl.handle.net/20.500.12645/37820
dc.language.isoen
dc.subjectB3 lesions
dc.subjectCore needle biopsy
dc.subjectbreast cancer
dc.subjectimage guided breast biopsy
dc.subjectvacuum assisted biopsy
dc.titleOutcomes of high-risk breast lesions diagnosed using image-guided core needle biopsy: results from a multicenter retrospective study.
dspace.entity.typePublication
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