Publication:
Comparison of the Effects of Low-Level Laser Therapy and Ozone Therapy on Bone Healing

dc.contributor.authorALAN, HİLAL
dc.contributor.authorVARDI, NİGAR
dc.contributor.authorOzgur, Cem
dc.contributor.authorHuseyin, Ahmet
dc.contributor.authorYOLCU, ÜMİT
dc.contributor.authorÖZDEMİR DOĞAN, DERYA
dc.date.accessioned2020-10-22T15:55:50Z
dc.date.available2020-10-22T15:55:50Z
dc.date.issued2015-07-01T00:00:00Z
dc.description.abstractThis study aims to compare the effect of low-level laser therapy (LLLT) and ozone therapy on the bone healing. Thirty-six adult male Wistar albino rats were used for this study. Monocortical defects were shaped in right femur of all rats. Defects were filled with nano-hydroxyapatite graft. The animals were divided into 3 groups and each group was than divided into 2 subgroups. Then, LLLT with a diode laser was applied to the first group (G1), ozone therapy was applied to the second group (G2), and no treatment was applied to the third group as a control group (G3). Animals were sacrificed after 4th and 8th weeks and the sections were examined to evaluate the density of the inflammation, the formation of connective tissue, the osteogenic potential, and osteocalcin activity. As a result, there were no significant differences among the groups of 4 weeks in terms of new bone formation. In the immunohistochemical assessment, the number of osteocalcin-positive cells was higher in the laser group compared to the other group of 4 weeks; this difference was statistically significant in the LLLT and ozone groups (P < 0.05). Histomorphometric assessment showed that the new bone areas were higher in the LLLT and ozone groups; furthermore, there was a statistically significant difference in the LLLT in comparison with the control group at 8th week (P < 0.05). At the same time immunohistochemical assessment showed that osteocalcin-positive cells were considerably higher in G2 than G1 at 8th week (P < 0.05). The findings of this study may be the result of differences in the number of treatment sessions. Further studies are therefore needed to determine the optimal treatment modality.
dc.identifier.citationALAN H., VARDI N., Ozgur C., Huseyin A., YOLCU Ü., ÖZDEMİR DOĞAN D., -Comparison of the Effects of Low-Level Laser Therapy and Ozone Therapy on Bone Healing-, JOURNAL OF CRANIOFACIAL SURGERY, cilt.26, 2015
dc.identifier.doi10.1097/scs.0000000000001871
dc.identifier.pubmed26167994
dc.identifier.scopus84965150687
dc.identifier.urihttp://hdl.handle.net/20.500.12645/23670
dc.identifier.wosWOS:000369611000010
dc.titleComparison of the Effects of Low-Level Laser Therapy and Ozone Therapy on Bone Healing
dc.typeArticle
dspace.entity.typePublication
local.avesis.id4d1953c6-eff8-4163-a621-6e8c905d5805
local.publication.isinternational1
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