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Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro

dc.contributor.authorHOSEK, Jan
dc.contributor.authorBARTOS, Milan
dc.contributor.authorCHUDIK, Stanislav
dc.contributor.authorDALL'ACQUA, Stefano
dc.contributor.authorINNOCENTI, Gabbriella
dc.contributor.authorKartal, MURAT
dc.contributor.authorKOKOSKA, Ladislav
dc.contributor.authorKOLLAR, Peter
dc.contributor.authorKUTIL, Zsofia
dc.contributor.authorLANDA, Premysl
dc.contributor.authorMAREK, Radek
dc.contributor.authorZAVALOVA, Veronika
dc.contributor.authorZEMLICKA, Milan
dc.contributor.authorSMEJKAL, Karel
dc.contributor.institutionauthorKARTAL, MURAT
dc.date.accessioned2020-10-29T22:41:02Z
dc.date.available2020-10-29T22:41:02Z
dc.date.issued2011-04-01T00:00:00Z
dc.description.abstractCudraflavone B (1) is a prenylated flavonoid found in large amounts in the roots of Morus alba, a plant used as a herbal remedy for its reputed anti-inflammatory properties. The present study shows that this compound causes a significant inhibition of inflammatory mediators in selected in vitro models: Thus, 1 was identified as a:potent inhibitor of tumor necrosis factor a (TNF alpha) gene expression and secretion by blocking the translocation of nuclear factor kappa B (NF-kappa B) from the cytoplasm to the nucleus in macrophages derived from a THP-1 human monocyte cell line. The NF-kappa B activity reduction resulted in the inhibition of cyclooxygenase 2 (COX-2) gene expression. Compound Cads as a COX-2 and COX-1 inhibitor with higher selectivity toward COX-2 than indomethacin. Pretreament of cells by 1 shifted the peak in an regulatory gene zinc finger protein 36 (ZFP36) expression assay. This natural product has noticeable anti-inflammatory properties suggesting that 1 potentially could be Used for development as a nonsteroidal anti inflammatory drug lead
dc.identifier.citationHOSEK J., BARTOS M., CHUDIK S., DALL-ACQUA S., INNOCENTI G., Kartal M., KOKOSKA L., KOLLAR P., KUTIL Z., LANDA P., et al., -Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro-, JOURNAL OF NATURAL PRODUCTS, cilt.74, ss.614-619, 2011
dc.identifier.doi10.1021/np100638h
dc.identifier.scopus79955394489
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26685
dc.identifier.wosWOS:000289742300011
dc.titleNatural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro
dc.typeArticle
dspace.entity.typePublication
local.avesis.idbbdf2dcd-bef2-4437-a33d-9144c1efca76
local.publication.goal08 - İnsana Yakışır İş ve Ekonomik Büyüme
local.publication.isinternational1
relation.isAuthorOfPublicationb30ec030-5f34-4c8b-814e-a7131d524a0a
relation.isAuthorOfPublication.latestForDiscoveryb30ec030-5f34-4c8b-814e-a7131d524a0a
relation.isGoalOfPublication42dc4679-bf07-41ff-b435-3ecfdcf74555
relation.isGoalOfPublication.latestForDiscovery42dc4679-bf07-41ff-b435-3ecfdcf74555
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