Publication: Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro
dc.contributor.author | HOSEK, Jan | |
dc.contributor.author | BARTOS, Milan | |
dc.contributor.author | CHUDIK, Stanislav | |
dc.contributor.author | DALL'ACQUA, Stefano | |
dc.contributor.author | INNOCENTI, Gabbriella | |
dc.contributor.author | Kartal, MURAT | |
dc.contributor.author | KOKOSKA, Ladislav | |
dc.contributor.author | KOLLAR, Peter | |
dc.contributor.author | KUTIL, Zsofia | |
dc.contributor.author | LANDA, Premysl | |
dc.contributor.author | MAREK, Radek | |
dc.contributor.author | ZAVALOVA, Veronika | |
dc.contributor.author | ZEMLICKA, Milan | |
dc.contributor.author | SMEJKAL, Karel | |
dc.contributor.institutionauthor | KARTAL, MURAT | |
dc.date.accessioned | 2020-10-29T22:41:02Z | |
dc.date.available | 2020-10-29T22:41:02Z | |
dc.date.issued | 2011-04-01T00:00:00Z | |
dc.description.abstract | Cudraflavone B (1) is a prenylated flavonoid found in large amounts in the roots of Morus alba, a plant used as a herbal remedy for its reputed anti-inflammatory properties. The present study shows that this compound causes a significant inhibition of inflammatory mediators in selected in vitro models: Thus, 1 was identified as a:potent inhibitor of tumor necrosis factor a (TNF alpha) gene expression and secretion by blocking the translocation of nuclear factor kappa B (NF-kappa B) from the cytoplasm to the nucleus in macrophages derived from a THP-1 human monocyte cell line. The NF-kappa B activity reduction resulted in the inhibition of cyclooxygenase 2 (COX-2) gene expression. Compound Cads as a COX-2 and COX-1 inhibitor with higher selectivity toward COX-2 than indomethacin. Pretreament of cells by 1 shifted the peak in an regulatory gene zinc finger protein 36 (ZFP36) expression assay. This natural product has noticeable anti-inflammatory properties suggesting that 1 potentially could be Used for development as a nonsteroidal anti inflammatory drug lead | |
dc.identifier.citation | HOSEK J., BARTOS M., CHUDIK S., DALL-ACQUA S., INNOCENTI G., Kartal M., KOKOSKA L., KOLLAR P., KUTIL Z., LANDA P., et al., -Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro-, JOURNAL OF NATURAL PRODUCTS, cilt.74, ss.614-619, 2011 | |
dc.identifier.doi | 10.1021/np100638h | |
dc.identifier.scopus | 79955394489 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12645/26685 | |
dc.identifier.wos | WOS:000289742300011 | |
dc.title | Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.avesis.id | bbdf2dcd-bef2-4437-a33d-9144c1efca76 | |
local.indexed.at | WOS | |
local.indexed.at | Scopus | |
local.publication.goal | 08 - İnsana Yakışır İş ve Ekonomik Büyüme | |
local.publication.isinternational | 1 | |
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