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Comparison of laser and ozone treatments on oral mucositis in an experimental model

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dc.contributor.authorBAYER, SUZAN
dc.contributor.authorKazancioglu, Hakki Oguz
dc.contributor.authorAcar, Ahmet Huseyin
dc.contributor.authorDemirtas, Nihat
dc.contributor.authorÖZTEN KANDAŞ, NUR
dc.contributor.institutionauthorBAYER, SUZAN
dc.contributor.institutionauthorÖZTEN KANDAŞ, NUR
dc.date.accessioned2020-10-22T21:37:18Z
dc.date.available2020-10-22T21:37:18Z
dc.date.issued2017-04-01T00:00:00Z
dc.description.abstractOral mucositis (OM) induces severe pain and limits fundamental life behaviors such as eating, drinking, and talking for patients receiving chemotherapy or radiotherapy. In addition, through opportunistic microorganisms, OM frequently leads to systemic infection which then leads to prolonged hospitalization. Severe lesions often adversely affect curative effects in cancer cases. Therefore, the control of OM is important for oral health quality of life and prognosis. Low-level laser therapy (LLLT) and ozone may be useful to accelerate wound healing. In this study, 24 Sprague-Dawley rats were divided into three groups as control, ozone, and laser groups. All groups received 5-fluorouracil intraperitoneally and trauma to the mouth pouch with a needle. After the formation of OM in the mouth, the control group had no treatment; the ozone group was administered ozone, and the laser group, LLLT. Then, all groups were sacrificed and basic fibroblast growth factor (bFGF), transforming growth factor (TGF-beta), and platelet-derived growth factor (PDGF) were evaluated in all groups. LLLT was determined to be statistically significantly more effective than ozone on FGF and PDGF. However, in respect of TGF-beta, no statistically significant difference was observed between the groups. In conclusion, within the limitations of this study, LLLT is more effective than ozone. However, further studies on this subject are required.
dc.description.sponsorshipBezmiâlem Vakıf Üniversitesi
dc.identifier.citationBAYER S., Kazancioglu H. O. , Acar A. H. , Demirtas N., ÖZTEN KANDAŞ N., -Comparison of laser and ozone treatments on oral mucositis in an experimental model-, LASERS IN MEDICAL SCIENCE, cilt.32, ss.673-677, 2017
dc.identifier.doi10.1007/s10103-017-2166-1
dc.identifier.pubmed28190112
dc.identifier.scopus85012134700
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24892
dc.identifier.wosWOS:000398716200022
dc.titleComparison of laser and ozone treatments on oral mucositis in an experimental model
dc.typeArticle
dspace.entity.typePublication
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local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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