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Can CA-125 Predict Lymph Node Metastasis in Epithelial Ovarian Cancers in Turkish Population?

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dc.contributor.authorSudolmus, Sinem
dc.contributor.authorKoroglu, Nadiye
dc.contributor.authorYildirim, Gokhan
dc.contributor.authorUlker, Volkan
dc.contributor.authorGulkilik, Ahmet
dc.contributor.authorDANSUK, RAMAZAN
dc.contributor.institutionauthorDANSUK, RAMAZAN
dc.date.accessioned2020-10-22T15:52:16Z
dc.date.available2020-10-22T15:52:16Z
dc.date.issued2014-01-01T00:00:00Z
dc.description.abstractObjective. The role of single preoperative serum CA-125 levels in predicting pelvic or paraaortic lymph node metastasis in patients operated for epithelial ovarian cancer has been investigated. Methods. 176 patients diagnosed with epithelial ovarian carcinoma after staging laparotomy between January 2002 and May 2010 were evaluated retrospectively. Results. The mean, geometric mean, and median of preoperative serum CA-125 levels were 632,6, 200,29, and 191,5 U/mL, respectively. The cut-off value predicting lymph node metastases in the ROC curve was 71,92 U/mL, which is significant in logistic regression analysis (P = 0.005). The preoperative log CA-125 levels were also statistically significant in predicting lymph node metastasis in logistic regression analysis (P = 0.008). Conclusions. The tumor marker CA-125, which increases with grade independent of the effect of stage in EOC, is predictive of lymph node metastasis with a high rate of false positivity in Turkish population. The high false positive rate may obscure the predictive value of CA-125.
dc.identifier.citationSudolmus S., Koroglu N., Yildirim G., Ulker V., Gulkilik A., DANSUK R., -Can CA-125 Predict Lymph Node Metastasis in Epithelial Ovarian Cancers in Turkish Population?-, DISEASE MARKERS, 2014
dc.identifier.doi10.1155/2014/492537
dc.identifier.pubmed24795494
dc.identifier.scopus84896975221
dc.identifier.urihttp://hdl.handle.net/20.500.12645/23538
dc.identifier.urihttps://www.hindawi.com/journals/dm/2014/492537/
dc.identifier.wosWOS:000333419500001
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOvarian Cancers
dc.titleCan CA-125 Predict Lymph Node Metastasis in Epithelial Ovarian Cancers in Turkish Population?
dc.typeArticle
dspace.entity.typePublication
local.avesis.id3e79f395-ae01-446a-ae19-abbaaa53a769
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication72babab4-8e8b-41f0-a56c-462b52434bff
relation.isAuthorOfPublication.latestForDiscovery72babab4-8e8b-41f0-a56c-462b52434bff
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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