Publication:
Impact of caffeic acid phenethyl ester treatment on vancomycin-induced pancreatic damage in rats

dc.contributor.authorKoyu, Ahmet
dc.contributor.authorGÖKALP, OSMAN
dc.contributor.authorGÜMRAL, Nurhan
dc.contributor.authorOktem, Faruk
dc.contributor.authorKARAHAN, Nermin
dc.contributor.authorYILMAZ, NİGAR
dc.contributor.authorSAYGIN, Mustafa
dc.date.accessioned2020-10-22T16:00:00Z
dc.date.available2020-10-22T16:00:00Z
dc.date.issued2016-02-01T00:00:00Z
dc.description.abstractThis study investigates the preventive effect of caffeic acid phenethyl ester (CAPE) on pancreatic damage induced by vancomycin (VCM) in rats. Rats were equally divided into three groups: group I (control), group II (only VCM-treated group) and group III (VCM + CAPE-treated groups). VCM was intraperitoneally administered at a dose of 200 mg kg(-1) twice daily for 7 days. CAPE was administered orally at 10 mu M mL(-1) kg(-1) dose once daily for 7 days. The first dose of CAPE administration was performed 24 h prior to VCM injection. Blood and pancreas tissue samples were removed and collected after the study. Serum alkaline phosphatase (ALP), amylase, g-glutamyl transferase (GGT) and lipase activities were determined. Pancreas tissue samples were evaluated with the light microscope. Group II significantly increased serum ALP, amylase, GGT and lipase activities when compared with the control group. Group III significantly decreased serum ALP, amylase, GGT and lipase activities when compared with group II. In histopathological examination, it has been observed that there was a significant pancreatic damage in group II. CAPE exerted prominent structural protection against VCM-induced pancreatic damage and this effect was statistically significant. CAPE caused a marked reduction in the extent of pancreatic damage. We have concluded that it may play an important role in the VCM-induced pancreatic damage and reduce the pancreatic damage both at the biochemical and histopathological aspects.
dc.identifier.citationKoyu A., GÖKALP O., GÜMRAL N., Oktem F., KARAHAN N., YILMAZ N., SAYGIN M., -Impact of caffeic acid phenethyl ester treatment on vancomycin-induced pancreatic damage in rats-, TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.32, ss.306-312, 2016
dc.identifier.doi10.1177/0748233713501708
dc.identifier.pubmed24097368
dc.identifier.scopus84956824031
dc.identifier.urihttp://hdl.handle.net/20.500.12645/23817
dc.identifier.wosWOS:000369179000015
dc.titleImpact of caffeic acid phenethyl ester treatment on vancomycin-induced pancreatic damage in rats
dc.typeArticle
dspace.entity.typePublication
local.avesis.id60e43328-c4f5-4d3d-9bdf-fdca022b1a1b
local.publication.isinternational1
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