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Preparation and in vitro evaluation of 5-flourouracil loaded magnetite-zeolite nanocomposite (5-FU-MZNC) for cancer drug delivery applications

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dc.contributor.authorSagir, Tugba
dc.contributor.authorHuysal, Merve
dc.contributor.authorDurmus, ZEHRA
dc.contributor.authorKurt, BELMA
dc.contributor.authorSenel, Mehmet
dc.contributor.authorIsik, Sevim
dc.contributor.institutionauthorZENGİN KURT, BELMA
dc.date.accessioned2019-10-05T15:02:37Z
dc.date.available2019-10-05T15:02:37Z
dc.date.issued2016-02-01
dc.description.abstractIn this work, super paramagnetic magnetite nanoparticles were synthesized onto/into zeolite, then loaded with anti-cancer drug 5-fluorouracil (5-FU). The physical properties of the prepared nanocomposite and drug loaded nanocomposite were characterized using different techniques. The drug loading and releasing behavior of the magnetic nanocarrier was investigated and the drug-loaded nanoparticles exhibited a sustained release of drug without any burst release phenomenon. Furthermore, 5-FU loaded MZNC were evaluated for its biological characteristics. The functional 5-FU-MZNC has been triggered intra-cellular release of the cancer therapeutic agent 5-fluorouracil (5-FU). Cytotoxic effects of 5-FU loaded MZNC on human gastric carcinoma (AGS) cells were determined by real time cell analysis and colorimetric WST-1 cell viability assay. Apoptosis of cells was further investigated by Annexin-V staining which indicates the loss of cell membrane integrity. According to our results, 5-FU-MZNC showed a concentration-dependent cell proliferation inhibitory function against AGS cells. Morphologic and apoptotic images were consistent with the cytotoxicity results. In conclusion, 5-FU loaded MZNC efficiently inhibit the proliferation of AGS cells in vitro through apoptotic mechanisms, and may be a beneficial agent against cancer, however further animal study is still required. (C) 2015 Elsevier Masson SAS. All rights reserved.
dc.description.sponsorshipBezmiâlem Vakıf Üniversitesi
dc.identifier
dc.identifier.citationSagir T., Huysal M., Durmus Z., Kurt B., Senel M., Isik S., -Preparation and in vitro evaluation of 5-flourouracil loaded magnetite-zeolite nanocomposite (5-FU-MZNC) for cancer drug delivery applications-, BIOMEDICINE & PHARMACOTHERAPY, cilt.77, ss.182-190, 2016
dc.identifier.doi10.1016/j.biopha.2015.12.025
dc.identifier.pubmed26796283
dc.identifier.scopus84954484890
dc.identifier.urihttps://hdl.handle.net/20.500.12645/5302
dc.identifier.wosWOS:000368104100027
dc.language.isoen
dc.titlePreparation and in vitro evaluation of 5-flourouracil loaded magnetite-zeolite nanocomposite (5-FU-MZNC) for cancer drug delivery applications
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameTRANSPLANT INTERNATIONAL
local.avesis.id82455b14-7ff7-4ed3-89ac-4d661910a984
local.avesis.response5172
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication3fd265b5-fdd8-4c56-949b-deb0303c3db7
relation.isAuthorOfPublication.latestForDiscovery3fd265b5-fdd8-4c56-949b-deb0303c3db7
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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