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CD40 ligand and P-selectin in heterozygous Beta-thalassemia

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dc.contributor.authorCIKRIKCIOGLU, Mehmet Ali
dc.contributor.authorSOYTAS, Rabia Bag
dc.contributor.authorKILIC, Elif
dc.contributor.authorToprak, Aybala Erek
dc.contributor.authorKaratoprak, CUMALİ
dc.contributor.authorZorlu, MEHMET
dc.contributor.authorKiskac, MUHARREM
dc.contributor.authorEMEGIL, Sebnem
dc.contributor.authorCetin, GÜVEN
dc.contributor.authorDogan, ELİF ECE
dc.contributor.authorSEKIN, Yahya
dc.contributor.authorHAMDARD, Jamshid
dc.contributor.institutionauthorÇAKIRCA, MUSTAFA
dc.contributor.institutionauthorZORLU, MEHMET
dc.contributor.institutionauthorKISKAÇ, MUHARREM
dc.contributor.institutionauthorÇETİN, GÜVEN
dc.contributor.institutionauthorDOĞAN, ELİF ECE
dc.contributor.institutionauthorKARATOPRAK, CUMALİ
dc.date.accessioned2019-10-05T14:17:22Z
dc.date.available2019-10-05T14:17:22Z
dc.date.issued2016-06-01
dc.description.abstractObjective: To investigate platelet functions and measure soluble CD40 ligand, soluble P-selectin, beta-thromboglobulin and platelet factor 4 levels in the blood of heterozygous beta thalassemia patients. Methods: The cross-sectional case-control study was conducted at Bezmialem Vakif University, Istanbul, Turkey, between September 2013 and April 2014, and comprised heterozygous beta thalassemia patients who were compared with 41 gender-, age- and body mass index-matched controls for platelet function markers. The two groups were also compared for co-morbidities, smoking, and regular medications. Results: Of the 78(78.78) subjects, 50(64%) were women and 28(36%) men with an overall mean age of 39.4±12.7 years (range: 18-79 years). The mean body mass index was 26.3±4.2. The heterozygous beta thalassemia group included 37(47%) subjects [24(65%) females; 13(35%) males] while the control group had 41(53%) [26(63%) females; 15(37%) males]. Soluble CD40 ligand and soluble P-selectin were lower in the heterozygous beta thalassemia group (p=0.009; p=0.010). Beta-thromboglobulin and platelet factor 4 levels were comparable between the groups (p=0.497; p=0.507.). Conclusions: Some platelet functions may be reduced in heterozygous beta thalassemia patients, which may be related to their lower incidence of cerebral and cardiac ischaemic events.en
dc.description.sponsorshipBezmiâlem Vakıf Üniversitesi
dc.identifier.citationCIKRIKCIOGLU M. A. , SOYTAS R. B. , KILIC E., Toprak A. E. , Cakirca M., Zorlu M., Kiskac M., EMEGIL S., Cetin G., Dogan E. E. , et al., -CD40 ligand and P-selectin in heterozygous Beta-thalassemia-, JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION, cilt.66, ss.699-704, 2016
dc.identifier.pubmed27339572
dc.identifier.scopus84969917054
dc.identifier.urihttps://hdl.handle.net/20.500.12645/3463
dc.identifier.wosWOS:000376687000015
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleCD40 ligand and P-selectin in heterozygous Beta-thalassemia
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameBIORHEOLOGY
local.avesis.id540a40c0-34f5-4e01-8feb-90a00b57ce75
local.avesis.response3333
local.org.facultyTıp Fakültesi
local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscovery4284e7e5-459a-470e-9da7-0d831f68cbbb
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