Publication:
Combating sars-cov-2 through lipoxins, proteasome, caveolin and nuclear factor-κb pathways in non-pregnant and pregnant populations.

dc.contributor.authorCelik, Onder
dc.contributor.authorCelik, Nilufer
dc.contributor.authorAydin, Suleyman
dc.contributor.authorBaysal, Bora
dc.contributor.authorAydin, Suna
dc.contributor.authorSaglam, Aylin
dc.contributor.authorGursu, Yagmur
dc.contributor.authorDalkilic, Semih
dc.contributor.authorUlas, Mustafa
dc.contributor.authorOzcil, Mustafa D
dc.contributor.authorTayyar, Ahter T
dc.contributor.authorCengiz, Ferhat
dc.contributor.authorUgur, Kader
dc.contributor.authorAkkoc, Ramazan Fazil
dc.contributor.authorErsahin, Aynur A
dc.date.accessioned2023-05-16T15:40:34Z
dc.date.available2023-05-16T15:40:34Z
dc.date.issued2020-06-04T21:00:00Z
dc.description.abstractIt can be misleading to think that the new severe acute respiratory syndrome coronavirus (SARS-CoV2) which has a very strong mutation and adaptation capabilities, uses only the angiotensin-converting enzyme II (ACE2) pathway to reach target cells. Despite all the precautions taken, the pandemic attack continues and the rapid increase in the number of deaths suggest that this virus has entered the cell through different pathways and caused damage through different mechanisms. The main reason why the ACE2 pathway comes to the fore in all scientific studies is that this receptor is located at the entry point of basic mechanisms that provide alveolo-capillary homeostasis. SARS-CoV-2 has to use nuclear factor-κB (NF-kB), caveloae, clathrin, lipoxin, serine protease and proteasome pathways in addition to ACE2 to enter the target cell and initiate damage. For this reason, while new drug development studies are continuing, in order to be beneficial to patients in their acute period, it is imperative that we are able to come up with drugs that activate or inhibit these pathways and are currently in clinical use. It is also critical that we adopt these new pathways to the treatment of pregnant women affected by SARS-CoV-2, based on the scientific data we use to treat the general population.
dc.identifier.pubmed32538775
dc.identifier.urihttps://hdl.handle.net/20.500.12645/38009
dc.language.isoen
dc.subjectACE2
dc.subjectNuclear factor-κB
dc.subjectOff label drugs
dc.subjectProteasome, Lipoxin
dc.subjectSARS-CoV-2
dc.subjectSerine protease.
dc.subjectViral entry pathways
dc.titleCombating sars-cov-2 through lipoxins, proteasome, caveolin and nuclear factor-κb pathways in non-pregnant and pregnant populations.
dspace.entity.typePublication
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