Publication: Outcomes of Percutaneous Coronary Intervention of the Left Main Coronary Artery Bifurcation: Insights from PROGRESS-BIFURCATION registry
dc.contributor.author | Uluganyan M. | |
dc.date.accessioned | 2024-12-01T21:50:50Z | |
dc.date.available | 2024-12-01T21:50:50Z | |
dc.date.issued | 2024-11-01 | |
dc.description.abstract | Background:There is limited data on the long-term outcomes of percutaneous coronary intervention (PCI) in patients with left main coronary artery (LM) bifurcation lesions.Methods:This retrospective, observational, cohort study was performed across 6 centers in the United States, Russia, and Turkey between 2013-2024, as part of the Prospective Global Registry of Percutaneous Coronary Intervention in Bifurcation Lesions (PROGRESS-BIFURCATION, NCT05100992). We examined procedural characteristics and follow-up outcomes of patients with versus without LM bifurcation lesions undergoing PCI. Multivariable adjusted hazard ratios (aHR) with 95% CI were calculated using Cox regression.Results:Of 1,089 patients who underwent bifurcation PCI, 289 (26.5%) underwent LM PCI. Patients in the LM group were older (70.1±11.9 vs 65.4±11.5 years; p<0.001) and had more comorbidities, such as diabetes, heart failure, prior PCI, and prior coronary artery bypass graft surgery. Two-stent techniques were more commonly used in LM patients vs. non-LM patients (39.3% vs 26.5%, p<0.001), with similar technical success (94.8% vs 95.9%, p=0.41) and procedural success (93.1% vs 93.1%; p=0.99). The incidence of in-hospital major adverse cardiovascular events (MACE) was higher in LM patients (7.9% vs 4.5%, p=0.04). During long-term follow-up LM PCI patients had higher mortality (aHR 3.17; 95% CI 1.22-8.18; p<0.001), without significant differences in MACE (aHR 1.81; 95% CI 0.93-3.52; p=0.08), myocardial infarction (aHR 0.50; 95% CI 0.07-3.52; p=0.50), and target-vessel PCI revascularization (aHR 2.56; 95% CI 0.75-8.78; p=0.14).Conclusion:Follow-up mortality in patients undergoing bifurcation PCI, classified according to whether they underwent left main or non-left main PCI. | |
dc.identifier.citation | Uluganyan M., "Outcomes of Percutaneous Coronary Intervention of the Left Main Coronary Artery Bifurcation: Insights from PROGRESS-BIFURCATION registry", CIRCULATION, cilt.150, ss.1, 2024 | |
dc.identifier.doi | 10.1161/circ.150.suppl_1.41401 | |
dc.identifier.issn | 0009-7322 | |
dc.identifier.uri | https://avesis.bezmialem.edu.tr/api/publication/a755e533-0bb9-4a9b-bf05-5e427a08397e/file | |
dc.identifier.uri | https://hdl.handle.net/20.500.12645/39882 | |
dc.identifier.volume | 150 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Health Sciences | |
dc.subject | Klinik Tıp (Med) | |
dc.subject | Clinical Medicine (Med) | |
dc.title | Outcomes of Percutaneous Coronary Intervention of the Left Main Coronary Artery Bifurcation: Insights from PROGRESS-BIFURCATION registry | |
dc.type | article | |
dspace.entity.type | Publication | |
local.avesis.id | a755e533-0bb9-4a9b-bf05-5e427a08397e |