Publication:
The effect of platelet-rich fibrin, platelet-rich plasma, and concentrated growth factor in the repair of full thickness rotator cuff tears

dc.contributor.authorCelikten M.
dc.contributor.authorŞAHİN H.
dc.contributor.authorSenturk G. E.
dc.contributor.authorBilsel K.
dc.contributor.authorPulatkan A.
dc.contributor.authorKAPICIOĞLU M.
dc.contributor.authorŞAKUL B. U.
dc.contributor.institutionauthorBİLSEL, İSMAIL KEREM
dc.contributor.institutionauthorKAPICIOĞLU, MEHMET
dc.date.accessioned2024-02-28T21:50:11Z
dc.date.available2024-02-28T21:50:11Z
dc.date.issued2024-01-01
dc.description.abstractBackground: Rotator cuff lesions rank among the prevalent causes of shoulder pain. Combining surgical interventions with growth factors, scaffolds, and stem cell therapies can effectively decrease the likelihood of rotator cuff repair recurrence. Platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF), isolated from blood and rich in growth factors, have a critical role in cell migration, cell proliferation, and angiogenesis during the tissue regeneration process. Investigations have further substantiated the beneficial impact of PRP and PRF on the biomechanical and histologic attributes of the tendon-bone interface. We aimed to investigate the effectiveness of CGF compared with PRF and PRP in the repair of rotator cuff lesions as a new treatment strategy. Methods: Incision was performed on both shoulder regions of 21 adult rabbits. After 8 weeks, both shoulders of the rabbits were repaired by suturing. PRF and CGF were administered to 2 separate groups along with the repair. Tissues were collected for biomechanical measurements and histologic evaluations. Results: Histologically, CGF, PRF, and PRP showed similar results to the healthy control group. The level of improvement was significant in the PRF and PRP groups. In the PRF group, the distribution of Ki67 (+), CD31 (+), and CD34 (+) cells was determined intensely in the tendon-bone junction regions. Apoptotic cells increased significantly in the repair group compared with the healthy group, whereas fewer apoptotic cells were found in the PRF-, PRP-, and CGF-applied groups. In the biomechanical results, no statistical difference was recorded among the groups. Conclusion: The use of PRF, PRP, and CGF in rotator cuff repair shows promise in shortening the treatment period and preventing the recurrence of rotator cuff lesions.
dc.identifier.citationCelikten M., ŞAHİN H., Senturk G. E., Bilsel K., Pulatkan A., KAPICIOĞLU M., ŞAKUL B. U., "The effect of platelet-rich fibrin, platelet-rich plasma, and concentrated growth factor in the repair of full thickness rotator cuff tears", Journal of Shoulder and Elbow Surgery, 2024
dc.identifier.doi10.1016/j.jse.2023.09.028
dc.identifier.issn1058-2746
dc.identifier.pubmed37898418
dc.identifier.scopus85184056088
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85184056088&origin=inward
dc.identifier.urihttps://hdl.handle.net/20.500.12645/39117
dc.relation.ispartofJournal of Shoulder and Elbow Surgery
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectCerrahi Tıp Bilimleri
dc.subjectOrtopedi ve Travmatoloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectSurgery Medicine Sciences
dc.subjectOrthopedics and Traumatology
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectCERRAHİ
dc.subjectORTOPEDİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectSURGERY
dc.subjectORTHOPEDICS
dc.subjectCerrahi
dc.subjectOrtopedi ve Spor Hekimliği
dc.subjectSurgery
dc.subjectOrthopedics and Sports Medicine
dc.subjectanatomy
dc.subjectBasic Science Study
dc.subjectconcentrated growth factor
dc.subjecthistology
dc.subjectHistology and Biomechanics
dc.subjectIn Vivo Animal Model
dc.subjectPlatelet-rich fibrin
dc.subjectplatelet-rich plasma
dc.subjectrabbit
dc.subjectrotator cuff tears
dc.titleThe effect of platelet-rich fibrin, platelet-rich plasma, and concentrated growth factor in the repair of full thickness rotator cuff tears
dc.typearticle
dspace.entity.typePublication
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relation.isAuthorOfPublication33bea6eb-2819-4537-8544-beab26dc66f0
relation.isAuthorOfPublication.latestForDiscoverydb1859ad-a3b3-4299-8b42-89a62b377d7d
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