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Vitamin D status in the first-trimester: effects of Vitamin D deficiency on pregnancy outcomes

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dc.contributor.authorAtes, SEDA
dc.contributor.authorSevket, OSMAN
dc.contributor.authorÖZCAN, PINAR
dc.contributor.authorÖZKAL, Fulya
dc.contributor.authorKaya, MEHMET ONUR
dc.contributor.authorDane, Banu
dc.contributor.institutionauthorATEŞ, SEDA
dc.contributor.institutionauthorŞEVKET, OSMAN
dc.contributor.institutionauthorÖZCAN, PINAR
dc.contributor.institutionauthorKAYA, MEHMET ONUR
dc.contributor.institutionauthorKILIÇOĞLU DANE, PAKİZER BANU
dc.date.accessioned2019-10-05T12:45:39Z
dc.date.available2019-10-05T12:45:39Z
dc.date.issued2016-01-01
dc.description.abstractObjective: To assess serum levels of 25-hydroxyvitamin D [25(OH)D] in the first trimester and to determine the factors affecting deficiency levels and its association with pregnancy outcomes. Methods: Serum 25(OH)D concentrations were measured at 11-14 weeks' gestation in 229 singleton pregnancies using liquid chromatography-tandem mass spectrometry. Results: The median serum 25(OH)D concentration was 10.8 ng/mL and 45.9% of women had severe vitamin D deficiency with concentrations of <10 ng/mL. Logistic regression analysis revealed that covered dressing style, lack of multivitamin intake, season of blood sampling (November-April) were factors associated with 25(OH)D deficiency. There was a negative correlation between 25(OH)D levels and gestational age at sampling. Low 25(OH)D levels were not associated with adverse pregnancy outcomes. Higher rate of cesarean section (CS) was noted in women with 25(OH)D ≥10 ng/mL compared to those with 25(OH)D < 10mg/ml (p= 0.01). Conclusion: A high prevalence of vitamin D deficiency was observed in early pregnancy which was related to dress code, use of multi-vitamins and season at sampling. Low 25(OH)D levels were not related with adverse pregnancy outcomes. Women with severe vitamin D deficiency were more likely to deliver vaginally.en
dc.identifier10.2174/1573405614666180101163751
dc.identifier.citationAtes S., Sevket O., ÖZCAN P., ÖZKAL F., Kaya M. O. , Dane B., -Vitamin D status in the first-trimester: effects of Vitamin D deficiency on pregnancy outcomes-, AFRICAN HEALTH SCIENCES, cilt.16, ss.36-43, 2016
dc.identifier.doi10.4314/ahs.v16i1.5
dc.identifier.pubmed27358611
dc.identifier.scopus84966309499
dc.identifier.urihttps://hdl.handle.net/20.500.12645/505
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915398/
dc.identifier.wosWOS:000378847700006
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subject25-hydroxyvitamin D
dc.subjectPregnancy outcome
dc.subjectVitamin D deficiency
dc.titleVitamin D status in the first-trimester: effects of Vitamin D deficiency on pregnancy outcomes
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameCURRENT MEDICAL IMAGING REVIEWS
local.avesis.id097ce375-54f2-4206-b4e8-ff8367bdeffe
local.avesis.response375
local.org.facultyTıp Fakültesi
local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscovery05accb91-e114-4a8a-b922-826c3a707026
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