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Evaluation of hepatitis serology and frequency of viral reactivation in patients with inflammatory arthritis receiving biologic agents: a multicenter observational study

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dc.contributor.authorÇAPKIN, ERHAN
dc.contributor.authorYAZICI, ALİ
dc.contributor.authorKARKUCAK, MURAT
dc.contributor.authorDurmaz, Yunus
dc.contributor.authorToprak, Murat
dc.contributor.authorATAMAN, ŞEBNEM
dc.contributor.authorSahin, Nilay
dc.contributor.authorCuzdan, Nihan
dc.contributor.authorKasapoglu Aksoy, Meliha
dc.contributor.authorOnder, Mustafa Erkut
dc.contributor.authorSerdaroglu Beyazal, Munevver
dc.contributor.authorMesci, Nilgun
dc.contributor.authorBaykul, Merve
dc.contributor.authorAlkan Melikoglu, Meltem
dc.contributor.authorAlkan, Hakan
dc.contributor.authorDulgeroglu, Deniz
dc.contributor.authorCengiz, Ahmet Kivanc
dc.contributor.authorNas, Kemal
dc.contributor.authorBalevi Batur, Elif
dc.contributor.authorCaliskan Uckun, Asli
dc.contributor.authorDeveci, Hulya
dc.contributor.authorErol, Kemal
dc.contributor.authorAlbayrak Gezer, Ilknur
dc.contributor.authorAkgol, Gurkan
dc.contributor.authorDuruoz, Mehmet Tuncay
dc.contributor.authorKucukakkas, Okan
dc.contributor.authorSarikaya, Selda
dc.contributor.authorRezvani, Aylin
dc.contributor.authorAtan, Tugba
dc.contributor.authorGogus, Feride
dc.contributor.authorCaglayan, Gokhan
dc.contributor.authorKESKİN, Yaşar
dc.contributor.authorBulut Keskin, Ayse Selcen
dc.contributor.authorOz, Nuran
dc.contributor.authorYilmaz, Gurdal
dc.contributor.institutionauthorKESKİN, YAŞAR
dc.date.accessioned2022-09-28T20:59:06Z
dc.date.available2022-09-28T20:59:06Z
dc.date.issued2022-09-01T00:00:00Z
dc.description.abstractTo evaluate of hepatitis serology and reactivation frequency in patients with rheumatic disease receiving biologic agents. Our study included patients with inflammatory rheumatic diseases from 23 centers, who were followed up with biological therapy. Demographic and clinical characteristics of the patients, duration of drug use and hepatitis serology and the state of viral reactivation were analyzed. A total of 4060 patients, 2095 being males, were included in our study. Of the patients, 2463 had Ankylosing Spondylitis (AS), 1154 had Rheumatoid Arthritis (RA), 325 had Psoriatic Arthritis (PsA), and 118 had other inflammatory rheumatic diseases. When the viral serology of the patients was evaluated, 79 patients (2%) who were identified as HBs Ag positive, 486 (12%) patients who were HBs Ag negative and anti-HBc IgG positive and 20 patients (0.5%) who were anti-HCV positive. When evaluated on a disease-by-disease basis, the rate of HBsAg was found to be 2.5% in RA, 2% in AS and 0.9% in PsA. Viral reactivation was detected in 13 patients while receiving biologic agents. HBs Ag was positive in nine patients with reactivation and negative in four patients. Anti-HBc IgG, however, was positive. Six of these patients had AS, four had RA, and three had PsA. The development of hepatitis reactivation in 11.4% of HBs Ag positive patients and 0.82% of anti-HBc IgG positive patients due to the use of biologic agents is an important problem for this group of patients. Antiviral prophylaxis is recommended to be started especially in patients who are HBs Ag positive and who are using biologic agents due to viral reactivation. Therefore, it is important to carry out hepatitis screenings before biologic agent treatment and to carefully evaluate the vaccination and prophylaxis requirements.
dc.identifier.citationÇAPKIN E., YAZICI A., KARKUCAK M., Durmaz Y., Toprak M., ATAMAN Ş., Sahin N., Cuzdan N., Kasapoglu Aksoy M., Onder M. E. , et al., -Evaluation of hepatitis serology and frequency of viral reactivation in patients with inflammatory arthritis receiving biologic agents: a multicenter observational study-, RHEUMATOLOGY INTERNATIONAL, 2022
dc.identifier.doi10.1007/s00296-022-05169-2
dc.identifier.pubmed36063169
dc.identifier.scopus85137505422
dc.identifier.urihttp://hdl.handle.net/20.500.12645/31033
dc.identifier.wosWOS:000849991500001
dc.titleEvaluation of hepatitis serology and frequency of viral reactivation in patients with inflammatory arthritis receiving biologic agents: a multicenter observational study
dc.typeArticle
dspace.entity.typePublication
local.avesis.id0b95ad48-911d-42ed-8ce4-12498c28ae8b
local.publication.isinternational1
relation.isAuthorOfPublication80372bf1-8306-440f-826c-809c70abd6d2
relation.isAuthorOfPublication.latestForDiscovery80372bf1-8306-440f-826c-809c70abd6d2
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