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Examination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo study

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dc.contributor.authorCakir, Ahsen
dc.contributor.authorBozali, Kubra
dc.contributor.authorCelikten, Mert
dc.contributor.authorGuler, Eray Metin
dc.contributor.authorSahan, Ebru
dc.contributor.authorDURDU, BÜLENT
dc.contributor.authorSÜMBÜL, BİLGE
dc.contributor.authorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.institutionauthorŞAHAN, EBRU
dc.contributor.institutionauthorDURDU, BÜLENT
dc.contributor.institutionauthorSÜMBÜL, BİLGE
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.date.accessioned2022-10-17T20:59:05Z
dc.date.available2022-10-17T20:59:05Z
dc.date.issued2022-10-01T00:00:00Z
dc.description.abstractSince most infectious diseases can develop into sepsis, it is still a major medical problem. Some in-vivo studies showed promising properties of fluoxetine in the treatment of infections. This study aims the antimicrobial effect of fluoxetine on the inflammatory process used in the treatment of sepsis-modeled rats. Besides, to investigate the efficacy of fluoxetine on modifying the antibiotic effect of imipenem in the inflammatory response. An experimental sepsis model was divided into negative control, positive control, fluoxetine 5 mg/kg, imipenem 60 mg/kg, and combined (fluoxetine; imipenem). Procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), lactate, myeloperoxidase activity (MPO), the inflammation markers interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alfa (TNF-alpha), and monocyte chemoattractant protein-1 (MCP-1) levels were measured by enzyme-linked immunosorbent assay method. Oxidative stress markers, total oxidant status (TOS), total antioxidant status (TAS), total thiol (TT), and native thiol (NT) were measured using photometric methods. Oxidative stress index (OSI) was calculated according to TAS and TOS levels. The statistical analysis was performed by Statistical Package for Social Sciences version 22.0. After treatment with fluoxetine, imipenem, and combined groups, IL-1 beta, IL-6, TNF-alpha, MPO activity, MCP-1, hs-CRP, PCT, lactate, and the oxidative stress markers OSI, and disulfide levels were decreased (p < 0.05). The TT, NT, and TAS levels significantly statistically increased (p < 0.05). This research demonstrates that fluoxetine has effects as anti-inflammatory and antioxidant, and the combined treatment with antibioticum imipenem indicates positive synergistic effects in the experimental sepsis model.
dc.identifier.citationCakir A., Bozali K., Celikten M., Guler E. M. , Sahan E., DURDU B., SÜMBÜL B., KOÇYİĞİT A., -Examination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo study-, JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2022
dc.identifier.doi10.1002/jbt.23240
dc.identifier.pubmed36214215
dc.identifier.urihttp://hdl.handle.net/20.500.12645/31125
dc.identifier.wosWOS:000865443800001
dc.titleExamination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo study
dc.typeArticle
dspace.entity.typePublication
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local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscovery1dd6de92-1cd1-44b2-9998-d4d24db6c649
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