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Effect of Photobiomodulation on Transforming Growth Factor-beta(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study

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dc.contributor.authorKeskiner, Ilker
dc.contributor.authorLutfioglu, Muge
dc.contributor.authorAydogdu, AHMET
dc.contributor.authorSaygun, N. Isil
dc.contributor.authorSERDAR, Muhittin Abdulkadir
dc.contributor.institutionauthorAYDOĞDU, AHMET
dc.date.accessioned2021-04-05T20:59:11Z
dc.date.available2021-04-05T20:59:11Z
dc.date.issued2016-06-01T00:00:00Z
dc.description.abstractObjective: This study evaluated the impact of photobiomodulation (PBM) on the healing of the donor palatal area following free gingival graft (FGG) harvesting by examining changes in transforming growth factor (TGF)-beta(1), platelet-derived growth factor (PDGF)-BB, and interleukin (IL)-8 levels in palatal wound fluid (PWF). Material and methods: Thirty patients were selected and randomly assigned to receive PBM (laser group) or PBM sham (sham group) in the palatine area after FGG harvesting. Aneodymium-doped yttrium aluminumgarnet (Nd:YAG) laser (1064 nm) was applied to the test sites immediately after surgery and every 24 h thereafter for 4 days. PWF was collected on Days 7 and 12, and PWF TGF-beta(1), PDGF-BB, and IL-8 levels were analyzed by enzyme-linked immunosorbent assays (ELISA). Results: PWF TGF-beta(1), PDGF-BB, and IL-8 levels were significantly lower on Day 12 than on Day 7 for both groups. PWF TGF-beta(1), PDGF-BB, and IL-8 levels of the laser group were significantly higher than those of sham group on Day 7 (p < 0.05). PWF TGF-beta(1) levels were also significantly higher in laser group than in the sham group on Day 12; however, differences in PDGF-BB and IL-8 levels between groups on Day 12 were statistically nonsignificant. Conclusions: Observed increases in PWF TGF-beta(1), PDGF-BB, and IL-8 levels suggest that PBM may accelerate wound healing by stimulating production of selected mediators.
dc.identifier.citationKeskiner I., Lutfioglu M., Aydogdu A., Saygun N. I. , SERDAR M. A. , -Effect of Photobiomodulation on Transforming Growth Factor-beta(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study-, PHOTOMEDICINE AND LASER SURGERY, cilt.34, sa.6, ss.263-271, 2016
dc.identifier.doi10.1089/pho.2016.4094
dc.identifier.scopus84973343163
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28663
dc.identifier.wosWOS:000377403000008
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEffect of Photobiomodulation on Transforming Growth Factor-beta(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study
dc.typeArticle
dspace.entity.typePublication
local.avesis.id6a1325d6-9162-4358-b498-239473978b90
local.publication.isinternational1
relation.isAuthorOfPublication74d25d67-861e-495b-8d4f-a1ede52301cd
relation.isAuthorOfPublication.latestForDiscovery74d25d67-861e-495b-8d4f-a1ede52301cd
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