Publication:
Possible Cytoprotective Potential of Ruthenium Red in Evaluation of the Rapid Apoptotic Model Induced by H2O2

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Date
2011-04-01T00:00:00Z
Authors
Bayram, Recep
Yavuz, Muhsine Zeynep
Duzenli, Selma
Gepdiremen, ALİ AKÇAHAN
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Research Projects
Sustainable Development Goals
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Abstract
In the present paper, hydrogen peroxide (H2O2) induced an apoptotic process in 1 h and over the doses of 10 mM, while cisplatin did not, in cortical neuronal homogenates of rats. It was proved in DNA fragmentation, MTT and WST-1 assays. Especially, according to WST-1 assay results, apoptotic effect was decided to be very obvious in all tests in the doses of 20 mM of the rapid model of apoptosis of H2O2. Ruthenium red, as a mitochondrial Ca2+ modulator, was tested alone and co-application with H2O2. Without H2O2, at low doses of it, ruthenium red seems to have a slight viability inducing effect in respect to controls in MTT and WST-1, despite that this effect was not observed clearly in DNA fragmentation test. Another point is that the highest dose of ruthenium red (10 M), induces apoptosis, even stronger than the 20 mM H2O2, controversy to the general believing.
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Bayram R., Yavuz M. Z. , Duzenli S., Gepdiremen A. A. , -Possible Cytoprotective Potential of Ruthenium Red in Evaluation of the Rapid Apoptotic Model Induced by H2O2-, ASIAN JOURNAL OF CHEMISTRY, cilt.23, ss.1795-1798, 2011