Publication:
Correlation of Caveolin-1 Expression with Prognosis in Patients with Gastric Cancer after Gastrectomy

Simple item page
dc.contributor.authorSeker, MESUT
dc.contributor.authorAYDIN, Dincer
dc.contributor.authorBilici, Ahmet
dc.contributor.authorYAVUZER, Dilek
dc.contributor.authorOZGUN, Melin G.
dc.contributor.authorOZCELIK, Melike
dc.contributor.authorAYDIN, Ozhan
dc.contributor.authorALIUSTAOGLU, Mehmet
dc.contributor.institutionauthorŞEKER, MESUT
dc.date.accessioned2019-10-05T13:37:25Z
dc.date.available2019-10-05T13:37:25Z
dc.date.issued2017-04-01
dc.description.abstractBackground: Upregulation of caveolin-1 (Cav-1) expression is correlated with histopathological grade and poor prognosis in several human cancers. However, in gastric cancer, its clinical utility as a useful prognostic molecular marker remains unclear. Methods: The prognostic importance of Cav-1 expression was retrospectively analyzed by immunohistochemistry in 148 patients with gastric cancer who had undergone radical gastrectomy. Results: Cav-1 expression was positive in 23 (15.5%) patients and negative in 125 (84.5%) patients. Tumor location, tumor grade, lymph node involvement, pT stage, pTNM stage, and the presence of recurrence were found to be significantly associated with Cav-1 expression. The median disease-free survival (DFS) of patients with negative Cav-1 expression was significantly better than that of patients with positive Cav-1 expression (not reached vs. 10.2 months, p < 0.001). Moreover, patients with positive Cav-1 expression had a worse median overall survival (OS) compared to patients with negative Cav-1 expression (14.2 vs. 40.3 months, p = 0.004). In the multivariate analysis, Cav-1 expression (positive vs. negative) was an independent prognostic factor for DFS (p < 0.001, hazard ratio (HR) 2.58) and OS (p = 0.031, HR 1.87), as was lymph node metastasis. Conclusion: Our results suggest that positive Cav-1 expression is associated with progression and poor prognosis in gastric cancer patients after radical gastrectomy. Targeting Cav-1 would be a potential option for future gastric cancer treatment. (C) 2017 S. Karger GmbH, Freiburg
dc.identifier10.1007/s00268-005-0440-z
dc.identifier.citationSeker M., AYDIN D., Bilici A., YAVUZER D., OZGUN M. G. , OZCELIK M., AYDIN O., ALIUSTAOGLU M., -Correlation of Caveolin-1 Expression with Prognosis in Patients with Gastric Cancer after Gastrectomy-, ONCOLOGY RESEARCH AND TREATMENT, cilt.40, ss.185-190, 2017
dc.identifier.urihttps://hdl.handle.net/20.500.12645/2549
dc.language.isoen
dc.titleCorrelation of Caveolin-1 Expression with Prognosis in Patients with Gastric Cancer after Gastrectomy
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameWorld journal of surgery
local.avesis.id3e3eac91-f2b4-4b2b-b5e5-c9aa18dc0115
local.avesis.response2419
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
relation.isAuthorOfPublication8a03684e-e421-4a9f-9069-168fc121a5d4
relation.isAuthorOfPublication.latestForDiscovery8a03684e-e421-4a9f-9069-168fc121a5d4
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
Files
Collections
Silinecekler