Publication: Correlation of Caveolin-1 Expression with Prognosis in Patients with Gastric Cancer after Gastrectomy
dc.contributor.author | Seker, MESUT | |
dc.contributor.author | AYDIN, Dincer | |
dc.contributor.author | Bilici, Ahmet | |
dc.contributor.author | YAVUZER, Dilek | |
dc.contributor.author | OZGUN, Melin G. | |
dc.contributor.author | OZCELIK, Melike | |
dc.contributor.author | AYDIN, Ozhan | |
dc.contributor.author | ALIUSTAOGLU, Mehmet | |
dc.contributor.institutionauthor | ŞEKER, MESUT | |
dc.date.accessioned | 2019-10-05T13:37:25Z | |
dc.date.available | 2019-10-05T13:37:25Z | |
dc.date.issued | 2017-04-01 | |
dc.description.abstract | Background: Upregulation of caveolin-1 (Cav-1) expression is correlated with histopathological grade and poor prognosis in several human cancers. However, in gastric cancer, its clinical utility as a useful prognostic molecular marker remains unclear. Methods: The prognostic importance of Cav-1 expression was retrospectively analyzed by immunohistochemistry in 148 patients with gastric cancer who had undergone radical gastrectomy. Results: Cav-1 expression was positive in 23 (15.5%) patients and negative in 125 (84.5%) patients. Tumor location, tumor grade, lymph node involvement, pT stage, pTNM stage, and the presence of recurrence were found to be significantly associated with Cav-1 expression. The median disease-free survival (DFS) of patients with negative Cav-1 expression was significantly better than that of patients with positive Cav-1 expression (not reached vs. 10.2 months, p < 0.001). Moreover, patients with positive Cav-1 expression had a worse median overall survival (OS) compared to patients with negative Cav-1 expression (14.2 vs. 40.3 months, p = 0.004). In the multivariate analysis, Cav-1 expression (positive vs. negative) was an independent prognostic factor for DFS (p < 0.001, hazard ratio (HR) 2.58) and OS (p = 0.031, HR 1.87), as was lymph node metastasis. Conclusion: Our results suggest that positive Cav-1 expression is associated with progression and poor prognosis in gastric cancer patients after radical gastrectomy. Targeting Cav-1 would be a potential option for future gastric cancer treatment. (C) 2017 S. Karger GmbH, Freiburg | |
dc.identifier | 10.1007/s00268-005-0440-z | |
dc.identifier.citation | Seker M., AYDIN D., Bilici A., YAVUZER D., OZGUN M. G. , OZCELIK M., AYDIN O., ALIUSTAOGLU M., -Correlation of Caveolin-1 Expression with Prognosis in Patients with Gastric Cancer after Gastrectomy-, ONCOLOGY RESEARCH AND TREATMENT, cilt.40, ss.185-190, 2017 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12645/2549 | |
dc.language.iso | en | |
dc.title | Correlation of Caveolin-1 Expression with Prognosis in Patients with Gastric Cancer after Gastrectomy | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.article.journalname | World journal of surgery | |
local.avesis.id | 3e3eac91-f2b4-4b2b-b5e5-c9aa18dc0115 | |
local.avesis.response | 2419 | |
local.publication.goal | 03 - Sağlık ve Kaliteli Yaşam | |
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