Publication:
Antimicrobial resistance of Helicobacter pylori strains to five antibiotics, including levofloxacin, in Northwestern Turkey

Simple item page
dc.contributor.authorCaliskan, Reyhan
dc.contributor.authorTokman, Hrisi Bahar
dc.contributor.authorErzin, Yusuf
dc.contributor.authorSaribas, Suat
dc.contributor.authorYuksel, Pelin
dc.contributor.authorBolek, Bora Kazim
dc.contributor.authorSevuk, Ecehan Ozge
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorYilmazli, Ozge
dc.contributor.authorAkgul, Ozer
dc.contributor.authorKalayci, Fatma
dc.contributor.authorCakan, Huseyin
dc.contributor.authorSalih, Barik
dc.contributor.authorBal, Kadir
dc.contributor.authorKocazeybek, Bekir
dc.contributor.institutionauthorYÜKSEL MAYDA, PELİN
dc.date.accessioned2020-10-29T20:04:13Z
dc.date.available2020-10-29T20:04:13Z
dc.date.issued2015-05-01T00:00:00Z
dc.description.abstractIntroduction: Antibiotic resistance is the main factor that affects the efficacy of current therapeutic regimens against Helicobacter pylori. This study aimed to determine the rates of resistance to efficacy clarithromycin, amoxicillin, tetracycline, levofloxacin and metronidazole among H. pylori strains isolated from Turkish patients with dyspepsia. Methods: H. pylori was cultured from corpus and antrum biopsies that were collected from patients with dyspeptic symptoms, and the antimicrobial susceptibility of H. pylori was determined using the E-test (clarithromycin, amoxicillin, tetracycline, metronidazole and levofloxacin) according to the EUCAST breakpoints. Point mutations in the 23S rRNA gene of clarithromycin-resistant strains were investigated using real-time PCR. Results: A total of 98 H. pylori strains were isolated, all of which were susceptible to amoxicillin and tetracycline. Of these strains, 36.7% (36/98) were resistant to clarithromycin, 35.5% (34/98) were resistant to metronidazole, and 29.5% (29/98) were resistant to levofloxacin. Multiple resistance was detected in 19.3% of the isolates. The A2143G and A2144G point mutations in the 23S rRNA-encoding gene were found in all 36 (100%) of the clarithromycin-resistant strains. Additionally, the levofloxacin MIC values increased to 32 mg/L in our H. pylori strains. Finally, among the clarithromycin-resistant strains, 27.2% were resistant to levofloxacin, and 45.4% were resistant to metronidazole. Conclusions: We conclude that treatment failure after clarithromycin-or levofloxacin-based triple therapy is not surprising and that metronidazole is not a reliable agent for the eradication of H. pylori infection in Turkey.
dc.identifier.citationCaliskan R., Tokman H. B. , Erzin Y., Saribas S., Yuksel P., Bolek B. K. , Sevuk E. O. , Demirci M., Yilmazli O., Akgul O., et al., -Antimicrobial resistance of Helicobacter pylori strains to five antibiotics, including levofloxacin, in Northwestern Turkey-, REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, cilt.48, ss.278-284, 2015
dc.identifier.doi10.1590/0037-8682-0027-2015
dc.identifier.scopus84933041136
dc.identifier.urihttp://hdl.handle.net/20.500.12645/25941
dc.identifier.wosWOS:000356868300008
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleAntimicrobial resistance of Helicobacter pylori strains to five antibiotics, including levofloxacin, in Northwestern Turkey
dc.typeArticle
dspace.entity.typePublication
local.avesis.id5bf4f6db-01c6-4cff-806b-d903a8508769
local.publication.isinternational1
relation.isAuthorOfPublicationa7da1ef6-442b-46fc-8c6c-601442ec1778
relation.isAuthorOfPublication.latestForDiscoverya7da1ef6-442b-46fc-8c6c-601442ec1778
Files
Collections
Silinecekler