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The role of miRNAs as a predictor of multicentricity in breast cancer.

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dc.contributor.authorAKBULUT, H
dc.contributor.authorERSOY, YELİZ EMİNE
dc.contributor.authorCOŞKUNPINAR, E
dc.contributor.authorGÜCİN, ZÜHAL
dc.contributor.authorYILDIZ, S
dc.contributor.authorMALYA, FATMA ÜMİT
dc.contributor.authorHASTÜRK, B
dc.contributor.authorMUSLUMANOGLU, MAHMUT
dc.contributor.institutionauthorERSOY, YELIZ EMINE
dc.contributor.institutionauthorGÜCİN, ZÜHAL
dc.contributor.institutionauthorYILDIZ, ŞEYMA
dc.contributor.institutionauthorMALYA, FATMA ÜMİT
dc.date.accessioned2019-10-05T21:28:33Z
dc.date.available2019-10-05T21:28:33Z
dc.date.issued2019-02-01
dc.description.abstractExpression profiles of miRNAs are shown to be different in various cancers to regulate expression of mRNA or to have a role in inhibition of translation, thus it shows the possible effect in progression, invasion and metastasis of breast cancer cells. The effect of breast conserving treatment in local recurrence and survival rates for the patients who have multicentric breast cancer is still controversial. In our study, we intended to evaluate the foresight of 84 miRNAs which are identified in breast cancer for having differentiated expressions. Thirty-one patients with unifocal and 26 patients with multicentric breast cancer were included in this study. These tissue samples of both malignant and normal breast tissues were kept in RNA later solution at -80 degrees C. Eighty-four miRNAs were studied with miScript miRNA PCR Array Human Breast Cancer kit. Fold change, cut off value was accepted as four. In unifocal group, there were 13 upregulated and five downregulated miRNAs and in multicentric group, there were three upregulated and seven downregulated miRNAs. To reach better results for breast cancer diagnosis and treatment, it is important to enlighten tumor biology, and pay attention to target and individual therapy. Thus, miRNAs have potential role in identifying tumor characteristics in supporting diagnosis and resulting with better evaluated disease for better treatment results with individual strategies.
dc.identifier10.1080/02688697.2018.1467373
dc.identifier.citationAKBULUT H., ERSOY Y. E. , COŞKUNPINAR E., GÜCİN Z., YILDIZ S., MALYA F. Ü. , HASTÜRK B., MUSLUMANOGLU M., -The role of miRNAs as a predictor of multicentricity in breast cancer.-, MOLECULAR BIOLOGY REPORTS, cilt.6, ss.1-10, 2019
dc.identifier.pubmed30707415
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7391
dc.language.isoen
dc.titleThe role of miRNAs as a predictor of multicentricity in breast cancer.
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameBRITISH JOURNAL OF NEUROSURGERY
local.avesis.idb8173175-179e-4e7c-b43c-706a38d580b7
local.avesis.response7267
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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