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Effects of Malnutrition on Neutrophil/Mononuclear Cell Apoptotic Functions in Children with Acute Lymphoblastic Leukemia

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dc.contributor.authorÇAKIR, FATMA BETÜL
dc.contributor.authorBerrak, Su Gülsün
dc.contributor.authorAydoğan, Gönül
dc.contributor.authorTulunay, Aysin
dc.contributor.authorTimur, Cetin
dc.contributor.authorCanpolat, Cengiz
dc.contributor.institutionauthorÇAKIR, FATMA BETÜL
dc.date.accessioned2019-10-05T15:27:15Z
dc.date.available2019-10-05T15:27:15Z
dc.date.issued2017-04-01
dc.description.abstractBackground: Recent studies claim that apoptosis may explain immune dysfunction observed in malnutrition. Objective: The objective of this study was to determine the effect of malnutrition on apoptotic functions of phagocytic cells in acute lymphoblastic leukemia (ALL). Materials and Methods: Twenty-eight ALL patients (13 with malnutrition) and thirty controls were enrolled. Neutrophil and mononuclear cell apoptosis of ALL patients and the control group were studied on admission before chemotherapy and repeated at a minimum of three months after induction of chemotherapy or when the nutritional status of leukemic children improved. Results: The apoptotic functions of both ALL groups on admission were significantly lower than those of the control group. The apoptotic functions were lower in ALL patients with malnutrition than those in ALL patients without malnutrition, but this was not statistically significant. The repeated apoptotic functions of both ALL groups were increased to similar values with the control group. This increase was found to be statistically significant. Conclusions: The apoptotic functions in ALL patients were not found to be affected by malnutrition. However, after dietary intervention, increased apoptotic functions in both ALL patient groups deserve mentioning. Dietary intervention should always be recommended as malnutrition or cachexia leads to multiple complications. Enhanced apoptosis might originate also from remission state of cancer.
dc.identifier
dc.identifier.citationÇAKIR F. B. , Berrak S. G. , Aydoğan G., Tulunay A., Timur C., Canpolat C., Eksioğlu-Demiralp E., -Effects of Malnutrition on Neutrophil/Mononuclear Cell Apoptotic Functions in Children with Acute Lymphoblastic Leukemia-, NUTRİTİON AND CANCER-AN INTERNATİONAL JOURNAL, cilt.69, ss.402-407, 2017
dc.identifier.pubmed28107040
dc.identifier.urihttps://hdl.handle.net/20.500.12645/6288
dc.language.isoen
dc.titleEffects of Malnutrition on Neutrophil/Mononuclear Cell Apoptotic Functions in Children with Acute Lymphoblastic Leukemia
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameUHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
local.avesis.id9c8a46f3-4ed8-4548-b7c9-631457a99c0f
local.avesis.response6158
local.publication.goal02 - Açlığa Son
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relation.isAuthorOfPublication.latestForDiscovery4b01ee0e-c087-44d4-9581-4d73032d078e
relation.isGoalOfPublication5246edf8-60d4-4a7b-9a27-c73e4a636141
relation.isGoalOfPublication.latestForDiscovery5246edf8-60d4-4a7b-9a27-c73e4a636141
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