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The Effect of Controlled Reperfusion in the Prevention of Infertility Caused by Ischemia Induced in the Contralateral Ovary in Rats with Unilateral Ovariectomy

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dc.contributor.authorAksoy, Ayse Nur
dc.contributor.authorAydin, Fatma
dc.contributor.authorYilmaz, Emsal Pinar Topdagi
dc.contributor.authorBatmaZ, Gonca
dc.contributor.authorSuleyman, Bahadir
dc.date.accessioned2020-10-29T14:56:19Z
dc.date.available2020-10-29T14:56:19Z
dc.date.issued2015-01-01T00:00:00Z
dc.description.abstractBackground/Aims: To investigate the effectiveness of controlled reperfusion (CR) on ovarian tissue malondialdehyde, total glutathione and 8-hydroxyguanine levels and infertility rates in a rat model of induced ischemia-reperfusion (I/R) injury with unilateral oophorectomy. Methods: A total of 135 adult female albino Wistar rats were divided into 9 groups (n = 15 for each group): unilateral ovariectomy + ovarian I/R (OIR), unilateral ovariectomy alone (OEG), a sham operation group (SG), and unilateral ovariectomy + CR performed at different intervals (the clips were released 10 times for 10, 8, 6, 4, 2 or 1 s and closed again 10 times for 10, 8, 6, 4, 2 or 1 s; OCR-1-6, respectively). Five rats from each group were sacrificed, and their ovaries were removed. Results: Higher ovarian tissue malondialdehyde and 8-hydroxyguanine levels and lower ovarian tissue total glutathione levels were found in the OIR group compared with the SG, OEG and OCR-4-6 groups. The number of rats giving birth during the study period was found to be similar among the SG (n = 8), OEG (n = 8) and OCR-6 (n = 7) groups. Conclusion: These results suggest that sterility and ovarian oxidative stress caused by I/R injury decreases in parallel to the shortening of CR duration. (C) 2015 S. Karger AG, Basel
dc.identifier.citationAksoy A. N. , Aydin F., Yilmaz E. P. T. , BatmaZ G., Suleyman B., -The Effect of Controlled Reperfusion in the Prevention of Infertility Caused by Ischemia Induced in the Contralateral Ovary in Rats with Unilateral Ovariectomy-, GYNECOLOGIC AND OBSTETRIC INVESTIGATION, cilt.80, ss.199-205, 2015
dc.identifier.doi10.1159/000377701
dc.identifier.scopus84946494916
dc.identifier.urihttp://hdl.handle.net/20.500.12645/25515
dc.identifier.wosWOS:000363830900009
dc.titleThe Effect of Controlled Reperfusion in the Prevention of Infertility Caused by Ischemia Induced in the Contralateral Ovary in Rats with Unilateral Ovariectomy
dc.typeArticle
dspace.entity.typePublication
local.avesis.id313563be-2a39-45d1-926d-f0465cec78d5
local.publication.isinternational1
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