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Endothelial Dysfunction and Atherosclerosis in Patients With Autosomal Dominant Polycystic Kidney Disease

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dc.contributor.authorBüyükbaba, Mitat
dc.contributor.authorÇınar, Ahmet
dc.contributor.authorTunç, Muhammed
dc.contributor.authorGürsu, Meltem
dc.contributor.authorKazancıoğlu, Rümeyza
dc.contributor.institutionauthorTUNÇ, MUHAMMED
dc.contributor.institutionauthorGÜRSU, MELTEM
dc.contributor.institutionauthorKAZANCIOĞLU, RÜMEYZA
dc.date.accessioned2021-03-18T20:59:06Z
dc.date.available2021-03-18T20:59:06Z
dc.date.issued2021-02-01T00:00:00Z
dc.description.abstractIntroduction In this study, we aimed to determine the endothelial dysfunction (ED) and atherosclerosis in patients with autosomal dominant polycystic kidney disease (ADPKD). Materials and methods This study was conducted with 83 subjects (26 male, mean age: 46±11 years) consisted of three groups including ADPKD, hypertension (HT) and healthy control groups. The groups were evaluated in terms of serum endocan and asymmetric dimethylarginine (ADMA) levels, flow-mediated dilatation (FMD), nitroglycerin-mediated dilation (NMD) and carotid intima-media thickness (CIMT). Results Serum endocan and ADMA levels and CIMT were significantly higher while NMD was significantly lower in ADPKD group than control group. FMD and NMD were lower but serum ADMA level was higher in the ADPKD group than HT group; while serum endocan level and CIMT were not significantly different in ADPKD and HT groups. In ADPKD patients, CIMT value and serum endocan and ADMA levels were higher while NMD was lower in patients with eGFR≤60 mL/min/1.73 m2 than patients with eGFR>60 mL/min/1.73 m2. Serum ADMA level was higher and NMD was lower in hypertensive ADPKD patients than non-hypertensive ones. Serum endocan level was higher in ADPKD patients with nephrolithiasis and a negative correlation was detected between serum endocan level and 24-hour urine volume. Conclusions Endothelial dysfunction and atherosclerosis are common conditions in ADPKD patients and it was further reinforced in our study. In order to clarify the relationship between serum endocan level and 24-hour urine volume, which is a remarkable finding in our study, larger studies that including the measurement of urine endocan may be useful.
dc.identifier.doi10.7759/cureus.13561
dc.identifier.pubmed33815976
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28608
dc.subjectasymmetric dimethylarginine
dc.subjectatherosclerosis
dc.subjectautosomal-dominant polycystic kidney disease
dc.subjectcarotid intima-media thickness
dc.subjectendocan
dc.subjectendothelial dysfunction
dc.subjectflow mediated dilatation
dc.subjectnitroglycerin mediated dilatio
dc.titleEndothelial Dysfunction and Atherosclerosis in Patients With Autosomal Dominant Polycystic Kidney Disease
dc.typeArticle
dspace.entity.typePublication
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local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscoverya6446eac-0ccd-4457-9227-3fc72dec68d1
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