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Tyrosinase Inhibitory Activity of Chemical Constituents of Euphorbia macrostegia

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dc.contributor.authorDemirkiran, Ozlem
dc.contributor.authorTopcu, GÜLAÇTI
dc.contributor.authorAZARPIRA, Ali
dc.contributor.authorCHOUDHARY, M. Iqbal
dc.contributor.institutionauthorTOPÇU, GÜLAÇTI
dc.date.accessioned2019-10-05T22:09:05Z
dc.date.available2019-10-05T22:09:05Z
dc.date.issued2014-11-01
dc.description.abstractThe chloroform extract of the aerial parts of E. macrostegia has yielded a new compound, 2-(4-hydroxyphenyl)-ethylhentriacontanoate (1), along with hentriacontan-1-ol (2), lupenone (3), cycloart-22-ene-3,25-diol (4), 3,3-,4--tri-O-methylellagic acid (5), cleomiscosin (6), and glucoclioniasterol (stigmast-5-en-3-O-beta-glucopyranoside) (7), and from the ethyl acetate extract of aerial parts of the plant isoquercetin (8), quercetin-3-O-alpha-arabinofuranoside (avicularin) (9), and rutin (10) have been isolated. Compounds 1-10 were tested for their tyrosinase inhibitory activity, and 2 exhibited an IC50 value of 71.4 mu M, almost comparable to standard kojic acid (IC50 58.2 mu M). Compounds 1-4 also showed good activity with IC50 values of 77.2, 78.6, 71.4, and 77.5 mu M, respectively.
dc.identifier10.1016/j.jss.2005.12.025
dc.identifier.citationDemirkiran O., Topcu G., AZARPIRA A., CHOUDHARY M. I. , -Tyrosinase Inhibitory Activity of Chemical Constituents of Euphorbia macrostegia-, CHEMISTRY OF NATURAL COMPOUNDS, cilt.50, ss.810-813, 2014
dc.identifier.urihttps://hdl.handle.net/20.500.12645/9032
dc.language.isoen
dc.titleTyrosinase Inhibitory Activity of Chemical Constituents of Euphorbia macrostegia
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJournal of Surgical Research
local.avesis.ide0c092ec-2aa8-42f4-acf3-aeffc4fb7a91
local.avesis.response8908
relation.isAuthorOfPublication3c94748e-c303-4294-ad67-c5a0739628e5
relation.isAuthorOfPublication.latestForDiscovery3c94748e-c303-4294-ad67-c5a0739628e5
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