Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study.

dc.contributor.authorUrgancı, Nafiye
dc.contributor.authorOzgenc, Funda
dc.contributor.authorKuloğlu, Zarife
dc.contributor.authorYüksekkaya, Hasan
dc.contributor.authorSarı, Sinan
dc.contributor.authorErkan, Tülay
dc.contributor.authorÖnal, Zerrin
dc.contributor.authorÇaltepe, Gönül
dc.contributor.authorAkçam, Mustafa
dc.contributor.authorArslan, Duran
dc.contributor.authorArslan, Nur
dc.contributor.authorArtan, Reha
dc.contributor.authorAydoğan, Ayşen
dc.contributor.authorBalamtekin, Necati
dc.contributor.authorBaran, Maşallah
dc.contributor.authorBaysoy, Gökhan
dc.contributor.authorÇakır, Murat
dc.contributor.authorDalgıç, Buket
dc.contributor.authorDoğan, Yaşar
dc.contributor.authorDurmaz, Özlem
dc.contributor.authorEcevıt, Çiğdem
dc.contributor.authorEren, Makbule
dc.contributor.authorGökçe, Selim
dc.contributor.authorGülerman, Fulya
dc.contributor.authorGürakan, Figen
dc.contributor.authorHızlı, Samil
dc.contributor.authorIşık, Ishak
dc.contributor.authorKalaycı, Ayhan Gazi
dc.contributor.authorKansu, Aydan
dc.contributor.authorKutlu, Tufan
dc.contributor.authorKarabiber, Hamza
dc.contributor.authorKasırga, Erhun
dc.contributor.authorKutluk, Günsel
dc.contributor.authorÖzbay Hoşnut, Ferdağ
dc.contributor.authorÖzen, Hasan
dc.contributor.authorÖzkan, Tanju
dc.contributor.authorÖztürk, Yeşim
dc.contributor.authorBekem Soylu, Özlem
dc.contributor.authorTutar, Engin
dc.contributor.authorTümgör, Gökhan
dc.contributor.authorÜnal, Fatih
dc.contributor.authorUgraş, Meltem
dc.contributor.authorÜstündağ, Gonca
dc.contributor.authorYaman, Aytaç
dc.contributor.authorStudy Group, Turkish Ibd
dc.description.abstractThe aim of the study was to evaluate familial Mediterranean fever (FMF) mutation analysis in pediatric patients with inflammatory bowel disease (IBD). The relation between MEFV mutations and chronic inflammatory diseases has been reported previously.
dc.description.abstractChildren with IBD (334 ulcerative colitis (UC), 224 Crohn's disease (CD), 39 indeterminate colitis (IC)) were tested for FMF mutations in this multicenter study. The distribution of mutations according to disease type, histopathological findings, and disease activity indexes was determined.
dc.description.abstractA total of 597 children (mean age: 10.8 ± 4.6 years, M/F: 1.05) with IBD were included in the study. In this study, 41.9% of the patients had FMF mutations. E148Q was the most common mutation in UC and CD, and M694V in IC (30.5%, 34.5%, 47.1%, respectively). There was a significant difference in terms of endoscopic and histopathological findings according to mutation types (homozygous/ heterozygous) in patients with UC (P < .05). There was a statistically significant difference between colonoscopy findings in patients with or without mutations (P = .031, P = .045, respectively). The patients with UC who had mutations had lower Pediatric Ulcerative Colitis Activity Index (PUCAI) scores than the patients without mutations (P = .007).
dc.description.abstractAlthough FMF mutations are unrelated to CD patients, but observed in UC patients with low PUCAI scores, it was established that mutations do not have a high impact on inflammatory response and clinical outcome of the disease.
dc.titleFamilial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study.