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Histopathological Evidence of Lymph Node Metastasis in Papillary Thyroid Carcinoma

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dc.contributor.authorCan, Nuray
dc.contributor.authorTastekin, Ebru
dc.contributor.authorOzyilmaz, Filiz
dc.contributor.authorSezer, Yavuz Atakan
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorSut, Necdet
dc.contributor.authorSarikas, Nurtac
dc.contributor.authorPuyan, Fulya Oz
dc.contributor.authorGÜLER, BERİL
dc.contributor.authorAyturk, Semra
dc.contributor.authorCelik, Mehmet
dc.contributor.institutionauthorGÜLER, BERIL
dc.date.accessioned2020-10-29T22:16:48Z
dc.date.available2020-10-29T22:16:48Z
dc.date.issued2015-09-01T00:00:00Z
dc.description.abstractProphylactic lymph node dissection is still controversial due to the potentially surgery-related morbidity in management of papillary thyroid carcinomas. So, some histopathological predictors for lymph node metastasis in thyroidectomy specimens may reveal importance. The objective of this study was to define histomorphological indicators of lymph node metastasis in the patients who had been performed thyroidectomy without lymph node dissection. Clinicopathological features of patients archived in Department of Pathology at Trakya University Medical Faculty were reviewed. A total of 211 patients who had been diagnosed as papillary carcinoma and had been performed total thyroidectomy/lobectomy with central/cervical lymph node dissection were included in the study. Clinical features (age, gender, preoperative/postoperative clinical, and laboratory findings) and histopathological features (histological variant, tumor size, focality, extrathyroidal extension, tumor border, lateral tubular growth, intraglandular dissemination, stromal and lymphocytic tumor response, lymphocytic thyroiditis, lymphovascular invasion, lymph node metastasis, number of metastatic lymph nodes, extranodal extension, size of the metastatic foci) were evaluated. Male gender, conventional variant, tumor size greater than 10 mm, multifocality, extrathyroidal extension, lateral tubular growth, intraglandular dissemination, lymphocytic and stromal tumor response, and absence of lymphocytic thyroiditis were predictive, and older age (>= 45 years) and follicular variant PTC were protective for lymph node metastasis. In order to optimize the management of papillary thyroid carcinomas, pathologists should search for the clues of lymph node metastasis particularly intraglandular dissemination, lateral tubular growth, tumor border and lymphocytic/stromal tumor response, multifocality, concomitant lymphocytic thyroiditis besides the actual prognostic criteria especially in younger aged male patients.
dc.identifier.citationCan N., Tastekin E., Ozyilmaz F., Sezer Y. A. , Guldiken S., Sut N., Sarikas N., Puyan F. O. , GÜLER B., Ayturk S., et al., -Histopathological Evidence of Lymph Node Metastasis in Papillary Thyroid Carcinoma-, ENDOCRINE PATHOLOGY, cilt.26, ss.218-228, 2015
dc.identifier.doi10.1007/s12022-015-9382-7
dc.identifier.scopus84938747029
dc.identifier.trdizintrdizin
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26516
dc.identifier.wosWOS:000358781300004
dc.titleHistopathological Evidence of Lymph Node Metastasis in Papillary Thyroid Carcinoma
dc.typeArticle
dspace.entity.typePublication
local.avesis.idaa5562a8-028f-4356-b74f-0f91a5753275
local.publication.isinternational1
relation.isAuthorOfPublicationfee8c5f9-2d88-41e7-8d6d-87789705739a
relation.isAuthorOfPublication.latestForDiscoveryfee8c5f9-2d88-41e7-8d6d-87789705739a
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