Publication:
A novel stability-indicating method for determination of a new antidepressant effect of vortioxetine in a pharmaceutical formulation by using RP-HPLC

dc.contributor.authorTIRIS, GİZEM
dc.contributor.authorAlver, Cansu
dc.contributor.authorERK, NEVİN
dc.contributor.institutionauthorTIRIS, GİZEM
dc.date.accessioned2022-01-06T20:59:17Z
dc.date.available2022-01-06T20:59:17Z
dc.date.issued2020-12-01T00:00:00Z
dc.description.abstractBackground: A novel rapid, accurate, and stability-indicating reversed-phase high performance liquid chromatographic (RP-HPLC) and first derivative spectrophotometric determination were explained for the assay of vortioxetine (VRT) in bulk and pharmaceutical formulations. For RP-HPLC method, optimal separation and determination of VRT were achieved with a Waters Symmetry C-18, (100 x 4.6 mm, 3.5 mu m) analytical column using a mobile phase consisting of methanol:0.05 M potassium dihydrogen phosphate (pH:3.0 +/- 0.05) (30:70, v/v) in isocratic mode with flow rate of 1.3 mL min(-1). Injection volume was 20 mu L. The maximum absorption wavelength of VRT is 225.0 nm; hence, 225.0 nm was studied as the detection wavelength and column at 50 degrees C temperature. The caffeine was used as the internal standard (IS). On the other hand, the first derivative spectrophotometric method for the analysis of vortioxetine was performed by measuring the amplitude at 251.7 and 272.6 nm.
dc.identifier.citationTIRIS G., Alver C., ERK N., -A novel stability-indicating method for determination of a new antidepressant effect of vortioxetine in a pharmaceutical formulation by using RP-HPLC-, FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.6, sa.1, 2020
dc.identifier.doi10.1186/s43094-020-00135-w
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29984
dc.identifier.wosWOS:000599936400001
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleA novel stability-indicating method for determination of a new antidepressant effect of vortioxetine in a pharmaceutical formulation by using RP-HPLC
dc.typeArticle
dspace.entity.typePublication
local.avesis.id17864ab9-0682-46cf-937b-abd9a752d77e
local.publication.isinternational1
relation.isAuthorOfPublication1ab47475-d54a-4b46-a679-47fb775bc1ce
relation.isAuthorOfPublication.latestForDiscovery1ab47475-d54a-4b46-a679-47fb775bc1ce
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