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Immunocytoexpression profile of ProExC in smears interpreted as ASC-US, ASC-H, and cervical intraepithelial lesion

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dc.contributor.authorTosuner, Zeynep
dc.contributor.authorTurkmen, Ilknur
dc.contributor.authorArici, Sema
dc.contributor.authorSonmez, Cavide
dc.contributor.authorTurna, Seval
dc.contributor.authorOnaran, Oyku
dc.contributor.institutionauthorTOSUNER, ZEYNEP
dc.contributor.institutionauthorTURNA, SEVAL
dc.date.accessioned2020-11-24T20:59:13Z
dc.date.available2020-11-24T20:59:13Z
dc.date.issued2017-01-01T00:00:00Z
dc.description.abstractAims: We aimed to investigate the immunocytoexpression profiles of a novel assay ProEx C for topoisomerase II alpha (TOP2A) and minichromosome maintenance protein 2 (MCM2) in abnormal interpreted smears. Settings and Design: Screening programs with Papanicolaou smear and high risk group human papilloma virus testing have yielded a dramatic reduction of cervical cancer incidence. However, both of these tests have limited specificity for the detection of clinically significant cervical high grade lesions. ProEx C for topoisomerase II alpha (TOP2A) and minichromosome maintenance protein 2 (MCM2) has been considered to have tight association with high grade intraepithelial lesions. Materials and Methods: A total number of 54 SurePath cervical cytology specimens of patients previously interpreted as atypical squamous cells-undetermined significance (ASC-US), atypical squamous cells-cannot exclude high grade squamous intraepithelial lesion (ASC-H), low grade squamous intraepithelial lesion (LSIL), and high grade squamous intraepithelial lesion (HSIL) were included in our study. Results and Conclusions: ProEx C was positive in 14 of HSILs (100%), 3 of 19 LSILs (16%), 2 of 4 ASC-Hs, and none of ASC-USs (0%). The ProEx C test showed very intense nuclear staining in all cytologically abnormal cells. Further studies are indicated to evaluate the diagnostic role of ProEx C.
dc.identifier.citationTosuner Z., Turkmen I., Arici S., Sonmez C., Turna S., Onaran O., -Immunocytoexpression profile of ProExC in smears interpreted as ASC-US, ASC-H, and cervical intraepithelial lesion-, JOURNAL OF CYTOLOGY, cilt.34, ss.34-38, 2017
dc.identifier.doi10.4103/0970-9371.197605
dc.identifier.pubmed28182079
dc.identifier.scopus85009505562
dc.identifier.urihttp://hdl.handle.net/20.500.12645/27432
dc.identifier.wosWOS:000393891700007
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleImmunocytoexpression profile of ProExC in smears interpreted as ASC-US, ASC-H, and cervical intraepithelial lesion
dc.typeArticle
dspace.entity.typePublication
local.avesis.idaea900ed-f2c8-4fb1-9b43-f7941d99083f
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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relation.isAuthorOfPublication539d924d-7145-4938-af8b-cddb5d5cde88
relation.isAuthorOfPublication.latestForDiscovery78184ff0-7bfc-4a7f-b855-737174d8fd00
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relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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