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Circulating furin, IL-6, and presepsin levels and disease severity in SARS-CoV-2-infected patients

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dc.contributor.authorKocyigit, Abdurrahim
dc.contributor.authorSogut, Ozgur
dc.contributor.authorKanimdan, Ebru
dc.contributor.authorGuler, Eray Metin
dc.contributor.authorKaplan, Onur
dc.contributor.authorEren, Canan
dc.contributor.authorOzman, Zeynep
dc.contributor.authorYasar, Oznur
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.institutionauthorBALKAN, EZGİ
dc.contributor.institutionauthorKANIMDAN, EBRU
dc.contributor.institutionauthorYENİGÜN, VILDAN BETÜL
dc.contributor.institutionauthorÖZMAN, ZEYNEP
dc.date.accessioned2021-07-01T20:59:05Z
dc.date.available2021-07-01T20:59:05Z
dc.date.issued2021-06-01T00:00:00Z
dc.description.abstractCoronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a vast number of infections and deaths that deeply affect the world. When the virus encounters the host cell, it binds to angiotensin-converting enzyme 2, then the S protein of the virus is broken down by the transmembrane protease serine 2 with the help of furin, allowing the virus to enter the cell. The elevated inflammatory cytokines suggest that a cytokine storm, also known as cytokine release syndrome, may play a major role in the pathology of COVID-19. Therefore, the aim of this study is to investigate the relationship between circulating furin levels, disease severity, and inflammation in patients with SARS-CoV-2. A total of 52 SARS-CoV-2 patients and 36 healthy control participants were included in this study. SARS- CoV-2 patients were scored by the disease activity score. Serum furin, presepsin, and interleukin-6 (IL-6) levels were assessed using an enzyme-linked immunosorbent assay. The mean furin, presepsin, and IL-6 levels were significantly higher in the peripheral blood of SARS-CoV-2 compared to the controls (p < 0.001). There were close positive relationship between serum furin and IL-6, furin and presepsin, and furin and disease severity (r = 0.793, p < 0001; r = 0.521, p < 0.001; and r = 0,533, p < 0.001, respectively) in patients with SARS-CoV-2. These results suggest that furin may contribute to the exacerbation of SARS-CoV-2 infection and increased inflammation, and could be used as a predictor of disease severity in COVID-19 patients.
dc.identifier.doi10.1177/00368504211026119
dc.identifier.pubmed34187224
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29016
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIL-6
dc.subjectSARS-CoV-2
dc.subjectdisease severity
dc.subjectfurin
dc.subjectinflammation
dc.subjectpresepsin
dc.titleCirculating furin, IL-6, and presepsin levels and disease severity in SARS-CoV-2-infected patients
dc.typeArticle
dspace.entity.typePublication
local.avesis.id57c277aa-f743-434f-abef-fea1762e30a8
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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