Person: HACIOSMANOĞLU, EBRU
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Publication Metadata only Impact of N‑Acetylcysteine and Antibiotics Against Single and Dual Species Bioflms of Pseudomonas aeruginosa and Achromobacter xylosoxidans(2022-11-01) Yılmaz F. N.; Hacıoğlu M.; Hacıosmanoğlu E.; HACIOSMANOĞLU, EBRUPublication Metadata only Anti-microbial, anti-oxidant and wound healing capabilities of Aloe vera-incorporated hybrid nanoflowers(2023-01-01) Altinkaynak C.; HACIOSMANOĞLU E.; Ekremoglu M.; HACIOĞLU M.; ÖZDEMİR N.; HACIOSMANOĞLU, EBRU© 2023 The Society for Biotechnology, JapanThe active ingredients of Aloe vera have attracted attention for their potential use in nanotechnology-based medical applications and biomaterial production. It has many therapeutic applications in modern world. This study used Aloe vera extract in different concentrations to synthesize Aloe vera-incorporated hybrid nanoflowers (AV-Nfs). The most uniform morphology in the nanoflowers obtained was at a concentration of 2 mL. The AV-Nfs were well characterized by scanning electron microscopy, X-ray spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction (XRD). The highest peroxidase-mimicking activity of the components was 1.488 EU/mg at 60°C and pH 6. The DPPH assay determined the antioxidant activity of the components and the MTT assay tested on CCD-1072Sk fibroblast cell line determined the effect of AV-Nfs on cell proliferation. Separate treatment of AV-Nfs with Cu3(PO4)2·3H2O significantly increased cell proliferation according to free Aloe vera and CuSO4. In vitro wound healing results showed that AV-Nfs could significantly close wounds compared to free Aloe vera. In this study, AV-Nfs showed antimicrobial activity against Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli and Klebsiella pneumoniae at minimum inhibitory concentration of 625 μg/mL, suggesting that AV-Nfs may be used in wound healing applications with enhanced biological properties. AV-Nfs showed no activity against the yeast Candida albicans.Publication Metadata only The Role of Some Selenoproteins in the Etiopathogenesis of Breast Cancer(2022-08-01) Öğüt S.; Hacıosmanoğlu E.; Değirmencioğlu S.; Bahtiyar N.; Cinemre F. B.; Aydemir B.; Karaçetin D.; Kural A.; Güneş M. E.; Bektaş M.; HACIOSMANOĞLU, EBRUPublication Metadata only Comparing the Neuroprotective Effects of Telmisartan, Perindopril, and Nebivolol Against Lipopolysaccharide-Induced Injury in Neuron-Like Cells.(2022-07-29) Şen S.; Hacıosmanoğlu E.; HACIOSMANOĞLU, EBRUPublication Metadata only Novel quinazoline–chromene hybrids as anticancer agents: Synthesis, biological activity, molecular docking, dynamics and ADME studies(2023-09-01) Tokalı F. S.; Şenol H.; Yetke H. İ.; Hacıosmanoğlu E.; ŞENOL, HALIL; YETKE, HANDE İPEK; HACIOSMANOĞLU, EBRUPublication Metadata only A novel EGFR Inhibitor, HNPMI regulates apoptosis and oncogenesis by modulating BCL-2/BAX and p53 in colon cancer.(2023-05-15) Kandhavelu J.; Subramanian K.; Naidoo V.; Sebastianelli G.; Doan P.; Mani S. K.; Yapislar H.; Haciosmanoglu E.; Arslan L.; Ozer S.; et al.; HACIOSMANOĞLU, EBRU