Person:
TERZİOĞLU, ŞULE

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ŞULE
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TERZİOĞLU
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Now showing 1 - 10 of 29
  • PublicationMetadata only
    Association of reelin silencing and topo isomerase IIβ expression in human SH-SY5Y neuroblastoma cell line
    (2019-09-07) TERZİOĞLU UŞAK, ŞULE; BEKER, MERVE; ELİBOL, BİRSEN; TERZİOĞLU, ŞULE; ELİBOL, BİRSEN; BEKER, MERVE
  • PublicationOpen Access
    Correlation of Brain Neuropeptide (Nesfatin-1 and Orexin-A) Concentrations with Anthropometric and Biochemical Parameters in Malnourished Children
    (2015-09-01) Kahraman, Feyza Ustabas; Vehapoglu, Aysel; Ozgen, Ilker Tolga; Terzioglu, Sule; Cesur, YAŞAR; Dundaroz, Rusen; VEHAPOĞLU TÜRKMEN, AYSEL; USTABAŞ KAHRAMAN, FEYZA; ÖZGEN, İLKER TOLGA; TERZİOĞLU, ŞULE; CESUR, YAŞAR; İŞCAN, AKIN
    Objective: Malnutrition continues to be a leading cause of stunted growth in many countries. This study aimed to investigate serum nesfatin-1 and orexin-A levels in underweight children and the potential correlations of these levels with anthropometric and nutritional parameters. Methods: The study enrolled 44 prepubertal children (between 2 and 12 years of age) with thinness grades of 1-3 and 41 healthy age- and gender-matched children. The demographic, clinical and laboratory parameters including nesfatin-1 and orexin-A concentrations were compared between the two groups. The correlations of nesfatin-1 and orexin-A with biochemical and anthropometric parameters were investigated. The receiver operating characteristic (ROC) analysis were also performed for evaluating nesfatin-1 and orexin-A in distinguishing children with malnutrition from healthy controls. Results: Thyroid-stimulating hormone, vitamin B12 and insulin levels were significantly lower in the study group than controls (p=0.001, p=0.049 and p=0.033, respectively). Mean nesfatin-1 levels in the malnourished group was also significantly lower compared to the healthy controls (3871.2 ± 1608.8 vs. 5515.0 ± 3816.4 pg/mL, p=0.012). No significant difference was observed in the orexin-A levels between the two groups (malnourished vs. control groups: 1135.7 ± 306.0 vs. 1025.7 ± 361.6 pg/mL, p=0.141). Correlation analyses revealed a positive correlation of nesfatin-1 and a negative correlation of orexin-A with body mass index (BMI) z-score. ROC analysis demonstrated that nesfatin-1 and orexin-A cannot be used to distinguish children with malnutrition from healthy controls (AUC: 0.620, p=0.061 for nesfatin-1 and AUC: 0.584, p=0.190 for orexin-A). Conclusion: The positive correlation of nesfatin-1 and the negative correlation of orexin-A with BMI suggest that these neuropeptides may be a part of a protective mechanism in the maintenance of nutritional status and that they may have a role in regulating food intake in undernourished children.
  • PublicationMetadata only
    Farklı Türde Uygulanmış Stresin Sıçanların HPA Ekseni ve Paratiroid Hormon Düzeyleri Üzerindeki Etkileri
    (2018-06-22) ELİBOL, BİRSEN; TERZİOĞLU, ŞULE; ELİBOL, BİRSEN; TERZİOĞLU, ŞULE
  • PublicationMetadata only
    Thymoquinone administration ameliorates Alzheimer-s disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta(1-42) infused rat model
    (2020-12-01T00:00:00Z) ELİBOL, BİRSEN; Beker, Merve; Terzioglu-Usak, Sule; Dalli, Tugce; Kilic, Ulkan; ELİBOL, BİRSEN; BEKER, MERVE; TERZİOĞLU, ŞULE
    Background: Thymoquinone (TQ), a biologically active ingredient of Nigella sativa, has anti-inflammatory, antioxidative and neuroprotective properties. Therefore, it could be a good candidate in the recovery of Alzheimer-s disease (AD) pathology rather than current symptomatic reliefs.
  • PublicationMetadata only
    Association of Alzheimer Disease With Dna Topoisomerase Iıß In Primary Neuronal Cells
    (2014-08-31) TERZİOĞLU UŞAK, ŞULE; SEVİM, İSİK; TERZİOĞLU, ŞULE
  • PublicationMetadata only
    Thymoquinone activates MAPK pathway in hippocampus of streptozotocin-treated rat model
    (2018-03-01) Elibol, BİRSEN; Akbas, FAHRİ; dallı, Tugce; Terzioglu-Usak, ŞULE; Beker, MERVE; BEKER, MERVE; TERZİOĞLU, ŞULE; AKBAŞ, FAHRİ; ELİBOL, BİRSEN
    Streptozotocin (STZ), a glucosamine-nitrosourea compound, produces deficiencies in learning, memory, and cognitive functions when it was administered intracerebroventricularly (i.c.v). In molecular level, increase in neuroinflammation and oxidative stress in brain, and decrease in the number of surviving neurons are the outcomes of STZ administration. Herein, we aimed to investigate the effect of thymoquinone (TQ), an anti-inflammatory, immunomodulatory and neuroprotective agent, on STZ-induced neurodegeneration in rats. For this purpose, bilateral i.c.v. injection of STZ (3 mg/kg) was given to adult female rats on days 1 and 3. TQ (20 mg/kg/day in cornoil) was administered intragastrically to rats for 15 days starting from the 15th day of STZ injection. The Morris water maze test and passive avoidance test were applied to measure the learning and memory performance of animals. Following the behavioral tests, all of the rats were sacrificed for evaluation of molecular alterations. Rats in the STZ-TQ group showed higher performance in passive avoidance test than rats in the STZ group whose memory performance declined compared to control group. The worse memory performance in STZ group was correlated with low number of surviving neurons and high number of degenerating neurons. In addition, an increase in APOE expression and a decrease in NGF expression were observed with STZ injection. Administration of TQ reversed these STZ-triggered cognitive and molecular alterations. In the present study, we observed the neuroregenerative effects of TQ by activation of JNK protein, upregulation of mir-124, and downregulation of ERK1/2 and NOS enzymes. The same ameliorative effect of TQ was also observed in the pTau protein expression. To sum up, we can say that the healing effect of TQ on STZ induced neurodegeneration opens a new door for the development of Alzheimer-s disease treatment using natural products as an adjuvant when their action mechanism was explained in detail.
  • PublicationMetadata only
    Low Dose Genistein Unlikely Induces Proliferation of PC3 Cells
    (2017-05-25) TERZİOĞLU UŞAK, ŞULE; ÖZTEN KANDAŞ, NUR; TERZİOĞLU, ŞULE; ÖZTEN KANDAŞ, NUR
  • PublicationMetadata only
    Timokinon Amyloid beta toksisitesini önlemek için töropatik amaçla kullanılabilir mi?
    (2017-05-10) dallı, Tuğçe; beker, merve; TERZİOĞLU UŞAK, ŞULE; AKBAŞ, FAHRİ; KILIÇ, ÜLKAN; ELİBOL, BİRSEN; BEKER, MERVE; TERZİOĞLU, ŞULE; AKBAŞ, FAHRİ; ELİBOL, BİRSEN
  • PublicationMetadata only
    Thymoquinone (TQ) demonstrates its neuroprotective effect via an anti-inflammatory action on the Aβ(1–42)-infused rat model of Alzheimer-s disease
    (2019-10-01) Elibol, Birsen; Şahbaz, Çiğdem Dilek; Beker, Merve; Terzioğlu, Şule; ELİBOL, BİRSEN; TERZİOĞLU, ŞULE; BEKER, MERVE; ŞAHBAZ, ÇIĞDEM DILEK
    OBJECTIVES: Alzheimer-s disease (AD) is a severe neurodegenerative disease with presentation of the neuronal death, memory loss and cognitive decline. The relationship between neuroinflammation and AD has been well documented. However, the options of anti-inflammatory treatment are very limited in patients with AD. Previous studies showed that flavonoids might be an effective treatment and thymoquinone (TQ), an aromatic hydrocarbon found in Nigella sativa suggested as a candidate molecule due to having strong anti-inflammatory effects. Our study aimed to investigate the effects of TQ on neuroinflammation and neuroprotection in A beta((1-42)) infused rat model of AD.
  • PublicationMetadata only
    In vitro Physiological Genistein Concentrations Do not Inhibit Proliferation in Prostate Cancer Cells
    (2017-03-26) ÖZTEN KANDAŞ, NUR; TERZİOĞLU UŞAK, ŞULE; ÖZTEN KANDAŞ, NUR; TERZİOĞLU, ŞULE