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MERİÇ KOÇ, MELİHA

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MELİHA
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MERİÇ KOÇ
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    İmmünsüpresif ilaç kullanan hastalarımızda aşılama oranı ve Hepatit B aşı etkinliği
    (2019-04-07T00:00:00Z) OKAY, GÜLAY; BİBERCİ KESKİN, ELMAS; MERİÇ KOÇ, MELİHA; OKAY, GÜLAY; BİBERCİ KESKİN, ELMAS; MERİÇ KOÇ, MELİHA
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    COVID-19-da Hastaneye Başvuru Sırasında Nörolojik Semptomlar: Tek Merkez Deneyemi- Ön Veriler
    (2021-01-15T00:00:00Z) Uslu, Ferda; Okay, Gülay; Meriç Koç, Meliha; Gürsoy, Azize Esra; USLU, FERDA; OKAY, GÜLAY; MERİÇ KOÇ, MELİHA; GÜRSOY, AZIZE ESRA
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    PublicationOpen Access
    Discordance between Serum Neutralizing Antibody Titers and the Recovery from COVID-19
    (2020-09-25T00:00:00Z) Koç, Mm; Kalkan, Yazıcı; Çetin, Nesibe Selma; Doymaz, Mz; Sümbül, B; Durdu, B; YAZICI, MERVE; MERİÇ KOÇ, MELİHA; ÇETİN, NESİBE SELMA; KARAASLAN, ELİF; OKAY, GÜLAY; DURDU, BÜLENT; SÜMBÜL, BİLGE; DOYMAZ, MEHMET ZIYA
    The recent pandemic of COVID-19 has caused a tremendous alarm around the world. Details of the infection process in the host have significant bearings on both recovery from the disease and on the correlates of the protection from the future exposures. One of these factors is the presence and titers of neutralizing Abs (NAbs) in infected people. In the current study, we set out to investigate NAbs in the recovered subjects discharged from the hospital in full health. Serum samples from a total of 49 documented consecutive COVID-19 subjects were included in the study. All the subjects were adults, and serum samples collected during the discharge were tested in viral neutralization, enzyme immunoassay (EIA), and Western immunoblot tests against viral Ags. Even though a majority of the recovered subjects had raised significant NAb titers, there is a substantial number of recovered patients (10 out of 49) with no or low titers of NAbs against the virus. In these cohorts as well as in patients with high NAb titers, viral Ag binding Abs were detectable in EIA tests. Both NAb titers and EIA detectable Abs are increased in patients experiencing a severe form of the disease, and in older patients the Ab titers were heightened. The main conclusion is that the recovery from SARS-CoV-2 infection is not solely dependent on high NAb titers in affected subjects, and this recovery process is probably produced by a complex interplay between many factors, including immune response, age of the subjects, and viral pathology.
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    Are Soap, Paper Towel and Alcohol-based Disinfectants Easily Accessible in Intensive Care Units in Turkey?: Results of the Phokai Study
    (2018-01-01T00:00:00Z) Uyan, Ayse; Durmus, Gul; Sezak, Nurbanu; Ozdemir, Burcu; Kaygusuz, Turkkan; Oztoprak, Nefise; Ozdemir, Keyser; AKSOY, FİRDEVS; Ozgultekin, Asu; Koc, MELİHA; Oncul, Ahsen; Cagan Aktas, Sabahat; Isik, Burcu; Celebi, Giiven; Evik, Guliiz; Ozger, Selcuk; Harman, Rezan; Dindar Demiray, Emine Kubra; Ozkoren Calik, Sebnem; Alkan Ceviker, Sevil; Yildiz, Ilknur Esen; Isik, Mehmet Emirhan; Senol, Gunes; Sari, Sema; Dogan, Mustafa; Ugurlu, Kenan; Arslan, Mustafa; Akgul, Fethiye; Koc, Filiz; Kurekci, Yeim; Caglayan, Derya; Ucar, Mehmet; Gozukucuk, Ramazan; Elmaslar Mert, Habibe Tulin; Alay, Handan; Erdogan, Haluk; Demirel, Aslihan; Dogan, Nilgun; Kocak, Funda; Guven, Emre; Unsal, Guieser; Sipahi, Hilal; Yamazhan, Tansu; Arda, Bilgin; Ulusoy, Sercan; Sipahi, Oguz Resat; MERİÇ KOÇ, MELİHA
    Introduction: Hand hygiene is one of the most effective infection control measures to prevent the spread of healthcare-associated infections (HCAI). Water, soap, paper towel and hand disinfectant must be available and adequate in terms of effective hand hygiene. The adequacy of hand hygiene products or keeping water-soap and paper towel is still a problem for many developing countries like Turkey. In this multicenter study, we analyzed the adequacy in number and availability of hand hygiene products.
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    Surgical site infection rates in 16 cities in Turkey: findings of the International Nosocomial Infection Control Consortium (INICC)
    (2015-01-01T00:00:00Z) Leblebicioglu, Hakan; Erben, Nurettin; ROSENTHAL, Victor D.; ŞENER, ALPER; UZUN, Cengiz; SENOL, Gunes; Ersoz, Gulden; Demirdal, Tuna; DUYGU, Fazilet; Willke, Ayse; Sirmatel, Fatma; OZTOPRAK, Nefise; Koksal, Iftihar; ONCUL, Oral; GURBUZ, Yunus; GUCLU, Ertugrul; Turgut, Huseyin; Yalcin, Ata Nevzat; Ozdemir, Davut; Kendirli, Tanil; ASLAN, Turan; Esen, Saban; Ulger, Fatma; Dilek, Ahmet; Yilmaz, Hava; Sunbul, Mustafa; Ozgunes, Ilhan; Usluer, Gaye; Otkun, Metin; Kaya, Ali; Kuyucu, Necdet; Kaya, Zeynep; Meric, MELİHA; Azak, Emel; Yylmaz, Gurdal; Kaya, Selcuk; Ulusoy, Hulya; HAZNEDAROGLU, Tuncer; GORENEK, Levent; ACAR, Ali; TUTUNCU, Ediz; KARABAY, Oguz; KAYA, Gulsume; Sacar, Suzan; Sungurtekin, Hulya; Ugurcan, Dogac; Turhan, Ozge; Kaya, Sehnaz; Gumus, Eylul; Dursun, Oguz; Geyik, Mehmet Faruk; Sahin, Ahmet; Erdogan, Selvi; Ince, Erdal; Karbuz, Adem; Ciftci, Ergin; Tasyapar, Nevin; Gunes, Melek; MERİÇ KOÇ, MELİHA
    Background: Surgical site infections (SSIs) are a threat to patient safety; however, there were no available data on SSI rates stratified by surgical procedure (SP) in Turkey.
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    Hand Hygiene Compliance in Some Intensive Care Units of Turkey: Results of Multicentre Asklepeion Study
    (2018-01-01T00:00:00Z) Onal, Aye Uyan; AKSOY, FİRDEVS; Azak, Emel; Koc, MELİHA; Ceviker, Sevil Alkan; Hatipoglu, Cigdem Ataman; Gozukucuk, Ramazan; Sehmen, Emine; Ugurlu, Kenan; Senol, Gunes; Durmus, Gul; Mert, Habibe Tulin Elmaslar; Alay, Handan; Koc, Filiz; Caglayan, Derya; Dikis, Demet; Korkmaz, Nilay Bilgili; Kucuker, Nilgiin Deniz; Kepeli, Nurhayat; Ulusoy, Behiye; Barik, Sukran Askit; Pullukcu, Husnu; Sipahi, Hilal; Arda, Bilgin; Ulusoy, Sercan; Sipahi, Oguz Resat; MERİÇ KOÇ, MELİHA
    Introduction: Hand hygiene is one of the most cost-effective infection control measures. In this multicenter Study we analysed the hand hygiene compliance observation results of 15 hospitals in Turkey.
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    Comparison of brucellar and tuberculous spondylodiscitis patients: results of the multicenter -Backbone-1 Study-
    (2015-12-01T00:00:00Z) ERDEM, Hakan; ELALDI, NAZİF; BATIREL, Ayse; ALIYU, Sani; SENGOZ, Gonul; PEHLIVANOGLU, Filiz; RAMOSACO, Ergys; GULSUN, Serda; Tekin, Recep; Mete, Birgul; Balkan, Ilker Inanc; SEVGI, Dilek Yildiz; GIANNITSIOTI, Efthymia; FRAGOU, Archontoula; Kaya, Selcuk; Cetin, Birsen; Oktenoglu, Tune; DoganCelik, Aygul; KARACA, Banu; Horasan, Elif Sahin; ULUG, Mehmet; MAN, Asuman; KAYA, Safak; Arslanalp, Esra; Ates-Guler, Selma; Willke, Ayse; Senol, Sebnem; Inan, Dilara; Guclu, Ertugrul; TUNCER-ERTEM, Gunay; Meric-Koc, MELİHA; Tasbakan, Meitem; SENBAYRAK, Seniha; CICEK-SENTURK, Gonul; Sirmatel, Fatma; OCAL, Gulfem; Kocagoz, Sesin; Kusoglu, Hulya; GUVEN, Turner; Baran, Ali Irfan; DEDE, Behiye; YILMAZ-KARADAG, Fatma; KOSE, Sukran; Yilmaz, Hava; ASIAN, Gonul; ALGALLAD, D. Ashraf; CESUR, Salih; EL-SOKKARY, Rehab; Bekiroglu, Nural; VAHABOGLU, Haluk; MERİÇ KOÇ, MELİHA
    BACKGROUND CONTEXT: No direct comparison between brucellar spondylodiscitis (BSD) and tuberculous spondylodiscitis (TSD) exists in the literature.
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    PublicationOpen Access
    Portraying infective endocarditis: results of multinational ID-IRI study
    (2019-09-01T00:00:00Z) Erdem, Hakan; Puca, Edmond; Ruch, Yvon; Santos, Lurdes; Ghanem-Zoubi, Nesrin; Argemi, Xavier; Hansmann, Yves; Guner, Rahmet; Tonziello, Gilda; Mazzucotelli, Jean-Philippe; Como, Najada; Kose, Sukran; Batirel, Ayse; Inan, Asuman; Tulek, Necla; Pekok, Abdullah Umut; Khan, Ejaz Ahmed; Iyisoy, Atilla; Meric-Koc, Meliha; Kaya-Kalem, Ayse; Martins, Pedro Palma; Hasanoglu, Imran; Silva-Pinto, Andre; Oztoprak, Nefise; Duro, Raquel; Almajid, Fahad; Dogan, Mustafa; Dauby, Nicolas; Gunst, Jesper Damsgaard; Tekin, Recep; Konopnicki, Deborah; Petrosillo, Nicola; Bozkurt, Ilkay; Wadi, Jamal; Popescu, Corneliu; Balkan, Ilker Inanc; Ozer-Balin, Safak; Zupanc, Tatjana Lejko; Cascio, Antonio; Dumitru, Irina Magdalena; Erdem, Aysegul; Ersoz, Gulden; Tasbakan, Meltem; Ajamieh, Oday Abu; Sirmatel, Fatma; Florescu, Simin; Gulsun, Serda; Ozkaya, Hacer Deniz; Sari, Sema; Tosun, Selma; Avci, Meltem; Cag, Yasemin; Celebi, Guven; Sagmak-Tartar, Ayse; Karakus, Sumeyra; Sener, Alper; Dedej, Arjeta; Oncu, Serkan; Del Vecchio, Rosa Fontana; Ozturk-Engin, Derya; Agalar, Canan; MERİÇ KOÇ, MELİHA
    Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042).
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    Early Detection of Methicillin Resistance by Real-Time PCR in Staphylococci Isolated from Blood Cultures
    (2012-10-01T00:00:00Z) Willke, Ayse; SAYAN, MURAT; Meric, MELİHA; MUTLU, BİRSEN; MERİÇ KOÇ, MELİHA
    Bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) has a significant morbidity and mortality. The aim of this study was to evaluate the efficiency of real-time polymerase chain reaction (Rt-PCR) targeting nuc and mec genes in the culture extracts of blood culture systems for the early diagnosis of MRSA. A total of 48 samples that gave positive growth signal in BACTEC 9000 MB (BD, USA) and stained as gram-positive cocci, were included in the study. The samples were collected between 2009 and 2010. VITEC 2 (bioMerieux, France) system was used for the identification and antibiotic susceptibility testing of the isolates. According to the culture results, 15 of the isolates were methicillin-resistant coagulase-negative staphylococci (MRCNS), four were MRSA, 14 were methicillin-susceptible coagulase-negative staphylococci (MSCNS) and 15 were methicillin-susceptible S.aureus (MSSA). However, Rt-PCR yielded 17 MRCNS, eight MRSA, 10 MSCNS and 13 MSSA results. Our findings indicated lack of concordance between blood culture and PCR technique. When the blood culture results were accepted as the gold standard for the determination of methicillin resistance, sensitivity, specificity, positive and negative predictive values of Rt-PCR were found as 73%, 62%, 56% and 78%, respectively. In conclusion, in contrast to the expectations, Rt-PCR was not considered as an appropriate method for the detection of MRSA in routine diagnosis.
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    PublicationOpen Access
    Analysis of infectious spondylodiscitis: 7-years data
    (2018-11-01) Koc, Meliha Meric; Okay, GÜLAY; Akkoyunlu, YASEMİN; Bolukcu, SİBEL; Durdu, BÜLENT; Hakyemez, Ismail Necati; OKAY, GÜLAY; AKKOYUNLU, YASEMİN; BOLUKÇU, SİBEL; DURDU, BÜLENT; HAKYEMEZ, İSMAİL NECATİ; MERİÇ KOÇ, MELİHA
    Objective: Infectious spondylodiscitis (SD) is an infectious disease that is rare and difficult to diagnose due to its non-specific clinical features. In this study, we aimed to describe the clinical and diagnostic features of infectious spondylodiscitis. Methods: All patients who were diagnosed with SD at our hospital during a 7-year period from January 1, 2011 through December 31, 2017 were included in the study. Spondylodiscitis is divided into the following three types: pyogenic, tuberculous, and brucellar. Clinical and laboratory data were collected retrospectively from the medical records of the patients. Results: Of the 118 patients, 66 (55.9%) were female, 81 (68.6%) had pyogenic SD (PSD), 21 (17.8%) had tuberculous SD (TSD), and 16 (13.6%) had brucellar SD (BSD). The mean age was 59.3 ± 14.6 years. Leucocytosis was significantly higher in patients with PSD (p=0.01) than in patients with other types of SD. Thoracic involvement (47.6%) was significantly higher in patients with TSD (p=0.005) than in other patients. Sacral involvement (12.5%) was significantly higher in patients with BSD (p=0.01) than in other patients. Paravertebral abscess formation (42.8%) occurred most frequently in patients with TSD. Microbiologic agents were defined in 50% (18/36) of the surgical specimens and in 12.5% of the fine needle aspiration biopsy (FNAB) specimens. Staphylococcus aureus was the most common microbiological agent in patients with PSD. Spinal surgery was defined as a risk factor for PSD (p = 0.0001). Binary logistic regression analysis revealed that female gender, thoracic involvement and night sweats were the predictive markers for TSD (OR 4.5 [95% CI 1.3-15.3] and OR 5 [95% CI 1.7-14.6]). Conclusion: PSD is the most frequent form of SD. Leucocytosis is most common in patients with PSD. Thoracic involvement and paraspinal abscess were prominent in patients with TSD. Sacral involvement was most common in patients with BSD. Thoracic involvement, female gender and night sweats were the predictive markers for TSD. The microbiological culture positivity rate was higher in surgical specimens compared to FNAB specimens. The need for surgical treatment was most common in patients with TSD.