Person: İÇAĞASIOĞLU, DİLARA FÜSUN
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Publication Metadata only Plasma Oxidative Stress and Total Thiol Levels in Crimean-Congo Hemorrhagic Fever(2014-01-01T00:00:00Z) Karadag-Oncel, Eda; EREL, Ozcan; ÖZSÜREKCİ, YASEMİN; CAGLAYIK, Dilek Yagci; KAYA, ALİ; Gozeol, Mustafa Gokhan; İÇAĞASIOĞLU, FÜSUN DİLARA; ENGİN, AYNUR; KORUKLUOGLU, Gulay; UYAR, Yavuz; Elaldi, Nazif; Ceyhan, Mehmet; İÇAĞASIOĞLU, DİLARA FÜSUNIn this study, we investigated the pro- and antioxidant status of patients with a pathogenesis of Crimean-Congo hemorrhagic fever (CCHF) in terms of their role in its pathogenesis. During the study period, 34 children and 41 adults were diagnosed with CCHF. The control group consisted of healthy age- and gender-matched children and adults. Serum levels of the total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), and plasma total thiol (TTL) were evaluated and compared between groups. The difference in mean TAC values between CCHF patients and healthy controls was not statistically significant (P > 0.05). Mean TOS, OSI, and TTL values were significantly lower in CCHF patients than in healthy controls (P 0.05). Our results suggest that TTL may play a more important role in CCHF pathogenesis than the other parameters investigated. The mean TOS and OSI values were higher in the control group than in CCHF patients.Publication Metadata only Elevated chemokine levels during adult but not pediatric Crimean-Congo hemorrhagic fever(2015-05-01T00:00:00Z) Arasli, Mehmet; ÖZSÜREKCİ, YASEMİN; ELALDI, NAZİF; MCAULEY, Alexander J.; Oncel, Eda Karadag; Tekin, Ishak Ozel; GÖZEL, MUSTAFA GÖKHAN; KAYA, ALİ; İÇAĞASIOĞLU, FÜSUN DİLARA; CAGLAYIK, Dilek Yagci; KORUKLUOGLU, Gulay; Kokturk, Furuzan; Bakir, Mehmet; BENTE, Dennis A.; Ceyhan, Mehmet; İÇAĞASIOĞLU, DİLARA FÜSUNBackground: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral zoonosis. Clinical reports indicate the severity of CCHF is milder in children than adults. The chemokines are important chemoattractant mediators of the host immune system.Publication Metadata only Bradycardia Seen In Children With Crimean-Congo Hemorrhagic Fever(2013-11-01T00:00:00Z) OFLAZ, Mehmet Burhan; KÜÇÜKDURMAZ, ZEKERİYA; GUVEN, A. Sami; KARAPINAR, HEKİM; KAYA, Ali; SANCAKDAR, ENVER; DEVECİ, KÖKSAL; GÜL, İBRAHİM; Erdem, Alim; CEVIT, Omer; Icagasioglu, F. Dilara; İÇAĞASIOĞLU, DİLARA FÜSUNIntroduction: Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic viral disease with a high mortality rate. In clinical practice, we observed bradycardia in some pediatric patients with CCHF during the clinical course. So we aimed to report CCHF cases that presented bradycardia during the clinical course and the relation of bradycardia with the clinical findings and ribavirin therapy. Methods: Charts of all hospitalized pediatric CCHF patients were reviewed with respect to age, sex, history of tick bite or history of removing a tick, other risk factors for CCHF transmission, and interval between the tick bite and the onset of symptoms. Outcomes and clinical and laboratory findings and medications were recorded for each patient. We searched the patient records for information regarding the existence of bradycardia. Bradycardia was accepted as the heart rate 2 standard deviations (SD) lower than the suspected heart rate based on age. Results: Fifty-two patients (mean age 11.24.4 years, 31 female) were enrolled into the study. Bradycardia was seen in seven patients. Six patients with bradycardia were male and only one was female, and the mean age was 13.1 +/- 1.6 years. It was observed that male gender is frequent among patients with bradycardia, as compared with those without bradycardia (p=0.01). Bleeding was found to be more frequent in patients with bradycardia (p=0.02). There were significant differences between the bradycardia and nonbradycardia groups with regard to the requirements for fresh frozen plasma transfusion, the number of platelet suspension given, requirement for intravenous immune globulin (IVIG) and in the days of stay in hospital (p=0.01, p=0.03, p=0.03, p=0.04, respectively). Conclusion: Reversible bradycardia might be seen in the clinical course of pediatric CCHF patients, and the clinicians must be aware of this finding. The possibility that ribavirin may potentiate bradycardia cannot be assessed without a placebo-control study. So further studies may help to reveal the cause of the bradycardia, the disease itself, or the ribavirin therapy. Hence this study supports the need for a randomized, placebo-controlled study to assess intravenous ribavirin in treating CCHF and to support approval of the drug.Publication Open Access PATIENT WITH INTERMITTENT POSTURE ABNORMALITY: AN ALEXANDER DISEASE CASE REPORT(2019-06-01T00:00:00Z) İÇAĞASIOĞLU, Dilara Füsun; İŞCAN, AKIN; ARALAŞMAK, Ayşe; NURSOY, HATİCE; YEŞİL, Gözde; AYDIN, NİHAL; Sahin, Seyma Sonmez; İÇAĞASIOĞLU, DİLARA FÜSUN; İŞCAN, AKIN; ARALAŞMAK, AYŞE; NURSOY, HATİCE; YEŞİL, GÖZDE; AYDIN, NİHALPublication Metadata only Spontaneous thrombosis in a patient with factor XI deficiency homozygous for the p.Cys398Tyr mutation(2014-07-01T00:00:00Z) Kilic, Suar Caki; İÇAĞASIOĞLU, FÜSUN DİLARA; GÜVEN, AHMET SAMİ; Berber, Ergul; İÇAĞASIOĞLU, DİLARA FÜSUNPublication Metadata only Prevalence of known mutations in the MEFV gene in a population screening with high rate of carriers(2011-06-01T00:00:00Z) ÖZDEMİR, ÖZTÜRK; SEZGİN, İLHAN; Kurtulgan, Hande Kucuk; CANDAN, FERHAN; Koksal, Binnur; Sumer, Haldun; Icagasioglu, Dilara; Uslu, Atilla; Yildiz, Fazilet; ARSLAN, SULHATTİN; Cetinkaya, Selma; Citli, Senol; Oztemur, Zekeriya; Kayatas, Mansur; İÇAĞASIOĞLU, DİLARA FÜSUNThe Familial Mediterranean Fever (FMF) shows an autosomal recessive pattern of inheritance and affects certain ethnic groups. Disease is caused by mutations in MEFV gene and more than 180 mutations have been defined in affected individuals. Current study aimed to determine the frequency-type of the mutations for MEFV gene in Sivas-middle Anatolian city. The cohort was composed of 3340 patients. MEFV gene mutations were studied by multiplex PCR based reverse hybridization stripAssay method. Patients- clinical features were; family history: 68%, erysipelas-like erythema: 17.6%, fever: 89.9%, abdominal pain: 84.2%, peritonitis: 90.2%, arthritis: 33%, pleuritis: 14.2%, parental consanguinity: 21.2%. Current results revealed that M694V is the most frequent mutation (43.12%), followed by E148Q (20.18), M680I(G/C) (15.00%) and V726A (11.32%). The study population has a high rate of carriers and the E148Q mutation frequency was found to be highest when compared to the other regions of Turkey and other Mediterranean groups.Publication Metadata only EPİLEPSİ , HİPOTONİ VE DİSMORFİK ÖZELLİKLER İLE PREZENTEOLAN DE NOVO İNTERSTİSYEL 4P DELESYONU(2018-11-11T00:00:00Z) Duman, Nilgün; YARARBAŞ, KANAY; Sayar, Ceyhan; Özciğer, Derya; İÇAĞASIOĞLU, DİLARA FÜSUN; DUMAN, NİLGÜN; İÇAĞASIOĞLU, DİLARA FÜSUNPublication Metadata only Treatment failure of gentamicin in pediatric patients with oropharyngeal tularemia(2011-07-01T00:00:00Z) KAYA, ALİ; UYSAL, İSMAİL ÖNDER; GÜVEN, AHMET SAMİ; ENGİN, AYNUR; GÜLTÜRK, ABDULAZİZ; İÇAĞASIOĞLU, FÜSUN DİLARA; Cevit, Omer; İÇAĞASIOĞLU, DİLARA FÜSUNBackground: Tularemia is a zoonotic infection, and the causative agent is Francisella tularensis. A first-line therapy for treating tularemia is aminoglycosides (streptomycin or, more commonly, gentamicin), and treatment duration is typically 7 to 10 days, with longer courses for more severe cases.Publication Metadata only The role of heparan sulphate in pathogenesis of Crimean-Congo hemorrhagic fever disease.(2013-04-01T00:00:00Z) AYDIN, HÜLYA GÜL; GUVEN, FM; KAYA, AYSEL; ENGIN, A; CELIK, VK; KORKMAZ, I; ATLI, B; Icagasioglu, DİLARA FÜSUN; AYDIN, HÜLYA GÜL; KAYA, AYSEL; İÇAĞASIOĞLU, DİLARA FÜSUNPublication Metadata only Value of ABO blood group in predicting the severity of children with Crimean-Congo hemorrhagic fever(2014-01-01T00:00:00Z) GÜVEN, AHMET SAMİ; SANCAKDAR, ENVER; KAYA, ALİ; UYSAL, ELİF BİLGE; OFLAZ, MEHMET BURHAN; BOLAT, FATİH; KARAPINAR, HEKİM; KOÇ, ELİF; İÇAĞASIOĞLU, FÜSUN DİLARA; İÇAĞASIOĞLU, DİLARA FÜSUNPurpose: The aim of this study was to assess the role of ABO blood groups in predicting disease severity and bleeding potential in children with Crimean-Congo hemorrhagic fever (CCHF). Methods: One hundred fifty-one hospitalized patients with CCHF were enrolled in this retrospective study. The patients were divided according to O- and non-O-(A, B and AB) blood groups (n=91 and n=60, respectively). They were also classified into two groups (severe and non-severe) based on disease severity (n=29 and n=122, respectively). Demographic characteristics, clinical findings, and hematologic and biochemical parameters of all patients were recorded on admission and discharge. Results: Although, in all cases, compared to the non-O blood group, the ratio of the blood group O was considerably higher (60% vs. 40%) and similarly so in severe cases (58.6% vs. 41.4%), this difference was not statistically significant (p>0.05). The aPTT at discharge and fever duration of the O-blood group were significantly higher than those of the non-O-blood group (p=0.042, p=0.034, respectively). The factor VIII level of the O-blood group was significantly lower than that of the non-O-blood group (p=0.040). Although the ratios of bleeding and severity were higher in the O-blood group compared to the other group, statistical significance was not reached (p>0.05). Conclusions: Consideration of the ABO blood group is important during diagnostic follow-up to assess the severity of CCHF. In clinical practice, pediatric CCHF patients with the O blood group need to be followed closely for tendency to bleed.