Person: EŞREFOĞLU, MUKADDES
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MUKADDES
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EŞREFOĞLU
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Conference Object Metadata only Specialized Pro-Resolving Lipid Mediators- New Therapeutic Approaches for Vascular Diseases(2023-11-23) Topal Tanyılmaz G.; Hekimoğlu E. R.; Eşrefoğlu M.; Çelik Z.; HEKİMOĞLU, EMİNE RÜMEYSA; EŞREFOĞLU, MUKADDESArticle Metadata only Clues to the Harmful Effects of Aspartame on Liver Morphology and Function(2022-12-01) Hekimoğlu E. R.; Elibol B.; Toruntay C.; Kırmızıkan S.; Pasin Ö.; Sarıkaya U.; Alkhalidi D.; Eşrefoğlu M.; HEKİMOĞLU, EMİNE RÜMEYSA; KIRMIZIKAN, SEDA; PASİN, ÖZGE; SARIKAYA, UFUK; EŞREFOĞLU, MUKADDESArticle Open Access Experimental and clinical evidence of antioxidant therapy in acute pancreatitis(2012-10-21) Esrefoglu, MUKADDES; EŞREFOĞLU, MUKADDESOxidative stress has been shown to play an important role in the pathogenesis of acute pancreatitis (AP). Antioxidants, alone or in combination with conventional therapy, should improve oxidative-stress-induced organ damage and therefore accelerate the rate of recovery. In recent years, substantial amounts of data about the efficiency of antioxidants against oxidative damage have been obtained from experiments with rodents. Some of these antioxidants have been found beneficial in the treatment of AP in humans; however, at present there is insufficient clinical data to support the benefits of antioxidants, alone or in combination with conventional therapy, in the management of AP in humans. Conflicting results obtained from experimental animals and humans may represent distinct pathophysiological mechanisms mediating tissue injury in different species. Further detailed studies should be done to clarify the exact mechanisms of tissue injury in human AP. Herein I tried to review the existing experimental and clinical studies on AP in order to determine the efficiency of antioxidants. The use of antioxidant enriched nutrition is a potential direction of clinical research in AP given the lack of clues about the efficiency and safety of antioxidant usage in patients with APArticle Open Access Harnessing autophagy: A potential breakthrough in digestive disease treatment(2024-06-01) Eşrefoğlu M.; EŞREFOĞLU, MUKADDESAutophagy, a conserved cellular degradation process, is crucial for variouscellular processes such as immune responses, inflammation, metabolic andoxidative stress adaptation, cell proliferation, development, and tissue repair andremodeling. Dysregulation of autophagy is suspected in numerous diseases,including cancer, neurodegenerative diseases, digestive disorders, metabolicsyndromes, and infectious and inflammatory diseases. If autophagy is disrupted,for example, this can have serious consequences and lead to chronic inflammationand tissue damage, as occurs in diseases such as Chron\"s disease and ulcerativecolitis. On the other hand, the influence of autophagy on the development andprogression of cancer is not clear. Autophagy can both suppress and promote theprogression and metastasis of cancer at various stages. From inflammatory boweldiseases to gastrointestinal cancer, researchers are discovering the intricate role ofautophagy in maintaining gut health and its potential as a therapeutic target.Researchers should carefully consider the nature and progression of diseases suchas cancer when trying to determine whether inhibiting or stimulating autophagyis likely to be beneficial. Multidisciplinary approaches that combine cutting-edgeresearch with clinical expertise are key to unlocking the full therapeutic potentialof autophagy in digestive diseasesArticle Metadata only Ageing-related alterations in rat stomach and intestines: A microscopic approach(2023-03-01) Kırmızıkan S.; Eşrefoğlu M.; KIRMIZIKAN, SEDA; EŞREFOĞLU, MUKADDESArticle Open Access Role of stem cells in repair of liver injury: experimental and clinical benefit of transferred stem cells on liver failure.(2013-10-28) Esrefoglu, MUKADDES; EŞREFOĞLU, MUKADDESAlthough the liver has a high regenerative capacity, as a result of massive hepatocyte death, liver failure occurs. In addition to liver failure, for acute, chronic and hereditary diseases of the liver, cell transplantation therapies can stimulate regeneration or at least ensure sufficient function until liver transplantation can be performed. The lack of donor organs and the risks of rejection have prompted extensive experimental and clinical research in the field of cellular transplantation. Transplantation of cell lineages involved in liver regeneration, including mature hepatocytes, fetal hepatocytes, fetal liver progenitor cells, fetal stem cells, hepatic progenitor cells, hepatic stem cells, mesenchymal stem cells, hematopoietic stem cells, and peripheral blood and umbilical cord blood stem cells, have been found to be beneficial in the treatment of liver failure. In this article, the results of experimental and clinical cell transplantation trials for liver failure are reviewed, with an emphasis on regeneration. © 2013 Baishideng. All rights reserved. Key words: Liver regeneration; Liver failure; Stem cell Core tip: Although the liver has a high regenerative capacity, as a result of massive hepatocyte death, liver failure occurs. In recent years, there has been extensive experimental and clinical research in the field of cellular transplantation. Transplantation of cell lineages involved in liver regeneration, including mature and fetal hepatocytes, fetal liver progenitor and stem cells, hepatic progenitor and stem cells, mesenchymal stem cells, hematopoietic stem cells, and peripheral blood and umbilical cord blood stem cells, have been found to be beneficial for treating of liver failure. Herein, I review the results of experimental and clinical cell transplantation trials for liver failure.Article Open Access Oxidative stress and benefits of antioxidant agents in acute and chronic hepatitis.(2012-03-01) Esrefoglu, MUKADDES; EŞREFOĞLU, MUKADDESContext: Oxidative damage due to oxidative stress is the failure of the cell’s defense against the deleterious effects of harmful agents by means of its numerous autoprotective mechanisms. Oxidative stress is a key impairment induced by various conditions, including atherosclerosis, hypertension, ischemia-reperfusion, hepatitis, pancreatitis, cancer, and neurodegenerative diseases. Evidence Acquisition: Oxidative stress is a common pathogenetic mechanism contributing to the initiation and progression of hepatic damage in cases of inflammatory liver disorders, including acute and chronic hepatitis. Antioxidant administration is a good therapeutic strategy for the treatment of hepatitis. Results: Our comprehensive review of the literature revealed that contradictory results have been obtained with many antioxidants and antioxidant agents. Conclusion: Since clinical studies to date have generally involved testing of the effects of antioxidant mixtures containing more than 2 antioxidants and also have been limited because of toxic effects of high doses of some antioxidants, antioxidant therapy for acute and chronic hepatitis needs further study.Article Metadata only Aging-related changes in rat kidney and testis: A microscopic approach(2022-11-01) Karakaya F. B.; Eşrefoğlu M.; KARAKAYA, FATMA BEDİA; EŞREFOĞLU, MUKADDESArticle Metadata only Changes in Histological Features, Apoptosis and Necroptosis, and Inflammatory Status in the Livers and Kidneys of Young and Adult Rats(2024-01-01) HEKİMOĞLU E. R.; EŞREFOĞLU M.; Elibol B.; KIRMIZIKAN S.; HEKİMOĞLU, EMİNE RÜMEYSA; EŞREFOĞLU, MUKADDES; ELİBOL, BİRSEN; KIRMIZIKAN, SEDAObjective: Aging entails a gradual rise in low-grade inflammation affected by cellular degeneration and death. Inflammaging refers to the chronic, low-grade inflammation that occurs alongside the aging process. This study attempts to evaluate the hepatic and renal histological changes, apoptosis and necroptosis rates, and inflammaging status of 6-week-old and 10-month-old rats. Materials and Methods: This study uses 12 male rats separated into two groups: Young Group (6-week-old rats; n = 6), and Adult Group (10-month-old rats; n = 6). Animals were sacrificed under anesthesia. The rats\" livers and kidneys were removed, and each organ tissue was divided into two parts: one for the microscopic examination (H&E and TUNEL immunohistochemistry) and the other for biochemical determination (tumor necrosis factor-alpha [TNF-α], nuclear factor-kappa beta [NF-κB], interleukin1-Beta [IL-1β], IL6, receptor-interacting serine/threonine protein kinase [RIP], and RIP3). Results: The histological features of the livers and kidneys of the 6-week-old rats were consistent with healthy mammalian organ features, while some histological changes were detected in sections of the 10-month-old rats. The apoptosis rate indicated by TUNEL immunohistochemistry was seen to have increased in the 10-month-old rats, while the necroptosis rate indicated by RIP3 Western-blotting analysis was conversely determined to have decreased. Significant increases in TNF-α and NF-κB levels were consistent with the increased apoptosis rate in the 10-month-old rats compared to the 6-week-old rats. Conclusion: One of the striking results of this study is that the degenerative changes related to aging began to be seen even in 10-month-old rats. The researchers used healthy rats of this age as control subjects as well as to create experimental models.Article Metadata only Hepatoprotective actions of melatonin by mainly modulating oxidative status and apoptosis rate in lipopolysaccharide-induced liver damage.(2023-12-05) Esrefoğlu M.; Kalkan T. K.; Karatas E.; Elibol B.; Hekimoglu E. R.; Karakaya Cimen F. B.; Yay A. H.; EŞREFOĞLU, MUKADDES
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