Person: BAKHSALIYEV, NIJAD
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Publication Metadata only Epicardial fat thickness assessment by multi-slice computed tomography for predicting cardiac outcomes in patients undergoing transcatheter aortic valve implantation(2021-10-01T00:00:00Z) Ertas, Gokhan; Ekmekci, Ahmet; Sahin, Sinan; Murat, Ahmet; BAKHSALIYEV, NIJAD; Erer, Hatice Betul; Guvenc, Tolga Sinan; Eren, Mehmet; BAKHSALIYEV, NIJADIntroduction: Chronic inflammation promotes aortic valve calcification. It is known that epicardial fat is a source of inflammation. The aim of this study was to investigate the relationship between epicardial fat thickness, cardiac conduction disorders and outcomes in patients undergoing transcatheter aortic valve implantation (TAVI). Methods: During a three-year period, 45 patients with severe aortic stenosis who underwent TAVI were recruited to the study. Data were collected retrospectively. Epicardial fat was defined as the adipose tissue between the epicardium and the visceral pericardium. Mean epicardial fat thickness was determined by multi-slice computed tomography, which was performed before the procedure. Results: The average thickness of epicardial fat was 13.06 ± 3.29 mm. This study failed to reveal a significant correlation between epicardial fat thickness and post-procedural left bundle branch block, right bundle branch block, paravalvular aortic regurgitation and pacemaker implantation rates (p > 0.05). Conclusions: The results of this study failed to show a significant relationship between epicardial fat thickness, cardiac conduction disorders and outcomes, however further studies with larger sample numbers are required to explore the relationship.Publication Open Access Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Myocardial Bridge.(2019-01-01T00:00:00Z) Bakshaliyev, N; Karacop, E; Cosansu, K; Huyut, MA; Turna, F; Enhos, A; Nadir, A; Ozdemir, R; Uluganyan, MAHMUT; ENHOŞ, ASIM; KARAÇÖP, ERDEM; BAKHSALIYEV, NIJAD; NADİR, AYDIN; ÖZDEMİR, RAMAZAN; ULUGANYAN, MAHMUTBackground: Assessing the monocyte to high-density lipoprotein ratio (MHR) is a new tool for predicting inflamation, which plays a major role in atherosclerosis. Myocardial bridge (MB) is thought to be a benign condition with development of atherosclerosis, particularly at the proximal segment of the brigde. Objective: To evaluate the relationhip between MHR and the presence of MB. Methods: We consecutively scanned patients referred for coronary angiography between January 2013- December 2016, and a total of 160 patients who had a MB and normal coronary artery were enrolled in the study. The patients’ angiographic, demographic and clinic characteristics of the patients were reviewed from medical records. Monocytes and HDL-cholesterols were measured via complete blood count. MHR was calculated as the ratio of the absolute monocyte count to the HDL-cholesterol value. MHR values were divided into three tertiles as follows: lower (8.25 ± 1.61), moderate (13.11 ± 1.46), and higher (21.21 ± 4.30) tertile. A p-value of < 0.05 was considered significant. Results: MHR was significantly higher in the MB group compared to the control group with normal coronary arteries. We found the frequency of MB (p = 0.002) to increase as the MHR tertiles rose. The Monocyte-HDL ratio with a cut-point of 13.35 had 59% sensitivity and 65.0% specificity (ROC area under curve: 0.687, 95% CI: 0.606-0.769, p < 0.001) in accurately predicting a MB diagnosis. In the multivariate analysis, MHR (p = 0.013) was found to be a significant independent predictor of the presence of MB, after adjusting for other risk factors. Conclusion: The present study revealed a significant correlation between MHR and MB.Publication Metadata only Kardiyoloji Konsultasyon Kitabı(2017-08-01T00:00:00Z) Bakhsalıyev, Nıjad; BAKHSALIYEV, NIJADPublication Open Access P Wave Duration/P Wave Voltage Ratio Plays a Promising Role in the Prediction of Atrial Fibrillation: A New Player in the Game(2021-05-01T00:00:00Z) KARAÇÖP, ERDEM; ENHOŞ, Asim; BAKHSALIYEV, NIJAD; ÖZDEMİR, Ramazan; KARAÇÖP, ERDEM; ENHOŞ, ASIM; BAKHSALIYEV, NIJAD; ÖZDEMİR, RAMAZANBackground. Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. Identification of patients at risk for developing AF and the opportunity for early targeted intervention might have a significant impact on morbidity and mortality. Prolonged P wave duration and decreased P wave voltage have been shown to be independent predictors of AF. The present study aimed to investigate the role of P wave duration/P wave voltage in predicting new-onset AF. Methods. We screened a total of 640 consecutive patients who admitted to cardiology outpatient clinic with a complaint of palpitation between 2012 and 2014. 24-h Holter monitoring, echocardiography, and electrocardiography (ECG) recordings were reviewed to identify new-onset AF. Patients were assigned into two groups based on presence (n = 150) and absence (n = 490) of new-onset AF. Previous ECGs with sinus rhythm were analyzed. P wave duration was measured in inferior leads, and P wave voltage was measured in lead one. P wave duration/P wave voltage was also calculated for each patient. Results. One hundred fifty subjects (23.4%) had new-onset AF among 640 patients. P wave duration (123.27 +/- 12.87 vs. 119.33 +/- 17.39 ms, p=0.024) and P wave duration/P wave voltage (1284.70 +/- 508.03 vs. 924.14 +/- 462.06 ms/mV, p<0.001) were higher, and P wave voltage (0.12 +/- 0.04 vs. 0.13 +/- 0.04 mV, p<0.001) was significantly lower in the new-onset AF group compared with non-AFs. P wave duration/P wave voltage, with a cut off of 854.5 ms/mV, had 83.3% sensitivity and 62.0% specificity in a receiver operating characteristic curve (AUC 0.728, 95% CI 0.687-0.769; p<0.001). Their negative and positive predictive values were 78.7% and 68.6%, respectively. In a univariate regression analysis, age, smoking, C-reactive protein, brain natriuretic peptide, left atrial diameter, left atrial volume index, P wave duration, P wave voltage, and P wave duration/P wave voltage were significantly associated with the development of new-onset AF. Moreover, smoking (OR 4.008, 95% CI 1.707-9.409; p=0.001), left atrial volume index (OR 7.108, 95% CI 4.400-11.483; p<0.001), and P wave duration/P wave voltage (OR 1.002, 95% CI 1.000-1.003; p=0.044) were found to be significant independent predictors of new-onset AF in a multivariate analysis, after adjusting for other risk parameters. Conclusion. The P wave duration/P wave voltage ratio is a practical, easy-to-use, cheap, and reliable electrocardiographic parameter, which can play a promising role for both in predicting and elucidating a mechanism of new-onset AF.Publication Metadata only THE RELATIONSHIP BETWEEN AORTIC ARCH CALCIFICATION AND ISOLATED SYSTOLIC HYPERTENSION(2022-06-16) Bakhsalıyev N.; BAKHSALIYEV, NIJADPublication Open Access The Impact of Admission Serum Creatinine Derived Estimated Glomerular Filtration Rate on Major Adverse Cardiac Events in ST Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention(2016-04-01) ULUGANYAN, MAHMUT; KARACA, GÜRKAN; ULUTAŞ, TÜRKER KEMAL; EKMEKÇİ, AHMET; BAKSHALİYEV, NİJAD; MURAT, AHMET; KÖROĞLU, BAYRAM; UYAREL, HÜSEYİN; EREN, MEHMET; ULUGANYAN, MAHMUT; BAKHSALIYEV, NIJADBackground: The impact of Cockroft-Gault (C-G) derived estimated glomerular filtration rate (eGFR) on mortality and major adverse cardiac events (MACEs) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) was assessed. Methods: A total of 884 patients were classified into four categories according to admission creatine derived eGFR: < 60, 60 - < 90, 90 - < 120, and ≥ 120 mL/min/1.73 m(2). Results: In-hospital and long-term MACEs were significantly higher in eGFR < 60 mL/min/1.73 m(2) subgroup (P < 0.001 and P = 0.028). Multivariate analysis demonstrated 7.78-fold (95% CI: 0.91 - 66.8) higher mortality risk in eGFR < 60 mL/min/1.73 m(2) subgroup. Conclusion: As an easily applicable bedside method, C-G derived eGFR could be important for prediction of in-hospital and long-term mortality and MACE in STEMI patients undergoing primary PCI.Publication Open Access The prognostic value of fragmented QRS in patients undergoing transcatheter aortic valve implantation(2018-11-01) Ay, Nuray Kahraman; ENHOŞ, ASİM; AY, YASİN; Ozdemir, Razaman; NADİR, AYDIN; KARAÇÖP, ERDEM; ÇELİKKALE, İLKE; ULUGANYAN, MAHMUT; Goktekin, Omer; KAHRAMAN AY, NURAY; ENHOŞ, ASIM; AY, YASİN; BAKHSALIYEV, NIJAD; NADİR, AYDIN; KARAÇÖP, ERDEM; ÇELİKKALE, İLKE; ULUGANYAN, MAHMUT; ÖZDEMİR, RAMAZANBackground Although transcatheter aortic valve implantation (TAVI) can successfully correct aortic narrowing, pre-existing pathophysiological alterations in the left ventricle are still a concern in terms of long-term mortality. This study aimed to examine the predictive role of fQRS morphology on long-term prognosis in patients undergoing TAVI due to severe aortic stenosis. Methods A total of 117 patients undergoing TAVI due to severe aortic stenosis were included in this retrospective cohort study. Patients were assigned into two groups based on the presence (n = 36) or absence (n = 81) of fQRS. Predictors of long-term survival were estimated. Results In-hospital mortality was higher in fQRS group (5.5% vs. 1.2%, p = 0.0224). In the long-term, fQRS (OR: 3.06, 95% CI 1.29–7.27, p: 0.01), LVEF <50% (OR: 2.54, 95% CI 1.07–6.02, p: 0.03) and presence of atrial fibrillation (OR: 2.42, 95% CI 1.05–5.60, p: 0.03) emerged as significant independent predictors of short survival. Conclusion Presence of fQRS on ECG, an indirect indicator of myocardial fibrosis, seems to have the potential to be used as a prognostic marker after TAVI procedure. Large prospective studies are warranted.Publication Metadata only TAPSE/PASP RATIO MAY PREDICT POOR PROGNOSIS FOLLOWING ATRIAL FLOW REGULATOR IMPLANTATION IN PATIENTS WITH HEART FAILURE(2022-09-16) Bakhsalıyev N.; BAKHSALIYEV, NIJADPublication Metadata only Palyatif Bakım ve Tıp(2019-01-01T00:00:00Z) Bakhsalıyev, Nıjad; BAKHSALIYEV, NIJADPublication Open Access THE IMPACT OF ATRIAL FLOW REGULATOR IMPLANTATION ON HEMODYNAMIC PARAMETERS IN PATIENTS WITH HEART FAILURE(2021-01-01T00:00:00Z) BAKHSALIYEV, NIJAD; ÖZDEMİR, Ramazan; BAKHSALIYEV, NIJAD; ÖZDEMİR, RAMAZANBackground Left atrial decompression has emerged a new option to treat patients with heart failure and dyspnea at rest or during exercise. Here we report the impact of atrial flow regulator (AFR) implantation on hemodynamic parameters in patients at our center with heart failure and with reduced (HFrEF) or with preserved left ventricular ejection fraction (HFpEF).