Person: ÇİMEN, YASİN ALİ
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Publication Metadata only Hippocampal and Hypothalamic FBN1 Expression in an Experimental Opioid Addiction Rat Model(2020-11-28T00:00:00Z) Eroğlu, Canan; Çimen, Yasin Ali; Yıldız, İbrahim; Kurar, Ercan; Kutlu, Selim; ÇİMEN, YASİN ALİHippocampal and Hypothalamic FBN1 Expression in an Experimental Opioid Addiction Rat Model Canan Eroglu Gunes1,2, Yasin Ali Cimen3, İbrahim Yildiz3, Ercan Kurar1,2, Selim Kutlu1,3 1Necmettin Erbakan University Neuroscience Research and Application Center (NENRC), Konya, Turkey 2Necmettin Erbakan University, Meram Faculty of Medicine, Department of Medical Biology, Konya, Turkey 3Necmettin Erbakan University, Meram Faculty of Medicine, Department of Physiology, Konya, Turkey AIM: FBN1 encodes a profibrillin and C-terminal cleavage product of this proprotein result in a fasting-induced protein hormone named Asprosin. FBN1 has critical roles in the formation of elastic fibers in connective tissues. Asprosin activates G protein-cAMP-PKA pathway and rapidly elevates serum glucose level. Asprosin can also cross blood-brain barrier and regulates hypothalamic neurons. In this study, hippocampal and hypothalamic FBN1 expression levelswere investigated in an experimental opioid addiction rat model. METHODS: A total of 18 rats were randomly divided into three equal groups including control (C), morphine dependent (M) and morphine dependent+ naloxone (M+N). Experimental dependence was constituted via applying 10 mg/kg/day subcutaneous morphine injection for 7 days. M+N group received intraperitoneal 1 mg/kg naloxone 1.5 hour after morphine injections. All animals were evaluated for morphine withdrawal symptoms and compared with the other groups. Hippocampus and hypothalamus tissues were dissected and mRNA level expression of FBN1 was evaluated by using quantitative RT-PCR. RESULTS: Steady state FBN1 expressions were determined in both hippocampus and hypothalamus. Morphine treatment significantly decreased FBN1 expression in hippocampus (p<0.01). An insignificant downregulation was also observed in hypothalamus of morphine group. Naloxone treatment tends to upregulated FBN1 expression in both hippocampus and hypothalamus. However, a significant increase was determined in M+N group compared to hypothalamus of C (p<0.05) and M (p<0.01) groups. CONCLUSION: These findings suggest that asprosin and/or other possible active peptides derived from FBN1 transcript may have modulatory roles in hippocampal formation. Additionally, in morphine dependent rat, increased FBN1 levels in M+N group comparing to both control and morphine groups indicated that there is an important opioid tonic inhibition on FBN1 expression in hypothalamus. Key words: Hypothalamus, hippocampus, opioid addiction, FBN1, asprosin.Publication Metadata only Kardiyovasküler Hastalıklarda Biyotinidaz ve TCA Enzim Aktivitelerinin İncelenmesi(2023-07-09) Sarıkaya U.; Çimen Y. A.; Taşlıdere B.; Selek Ş.; Açıkgöz N.; Meral İ.; SARIKAYA, UFUK; ÇİMEN, YASİN ALİ; TAŞLIDERE, BAHADIR; SELEK, ŞAHABETTİN; AÇIKGÖZ, NUSRET; MERAL, İSMAİLPublication Metadata only Masaj NotlarıDeğerlendirme ve Tedavi Cep Rehberi(2019-01-01T00:00:00Z) AKKOYUN SERT, ÖZLEM; BAYRAK, AHMET; ÜNÜVAR, BAYRAM SÖNMEZ; Çelik, Fatih; GERÇEK, HASAN; TAT, NECATİ MUHAMMED; ÇİMEN, YASİN ALİ; ÇİMEN, YASİN ALİPublication Metadata only Reliability and validity of the Turkish version of Fullerton Advanced Balance Scale in cerebral palsy(2022-07-01T00:00:00Z) ERTURAN, SİNEM; ATALAN, PELİN; ÇİMEN, YASİN ALİ; GÖKMEN, DERYA; Sert, Ozlem Akkoyun; Yilmaz, Kamil; ELBASAN, BÜLENT; ÇİMEN, YASİN ALİBackground: The Fullerton Advanced Balance Scale (FAB) is a multi-item balance assessment test designed to measure balance in relatively higher functioning individuals. The aim of this study was to examine the reliability and validity of the Turkish version of the FAB (FAB-T) in children with cerebral palsy (CP). Research question: Is the Turkish version of the Fullerton Advance Balance Scale valid and reliable in determining balance problems in children with cerebral palsy and determining the underlying cause of this condition? Methods: Forty-six children with CP participated in this study. Rasch analysis was used to investigate item adherence. Internal consistency of the FAB-T was established using Cronbach-s alpha coefficient. Test-retest reliability was also evaluated. In addition, to assess concurrent validity, FAB-T scores were compared with the Pediatric Balance Scale (PBS) using the Spearman correlation coefficient. Results: The FAB-T showed satisfactory internal consistency (Cronbach-s alpha value=0.94) and excellent testretest reliability (ICC=0.99). The FAB and the PBS exhibited concurrent positive validity (r = 0.913; p < 0.001). All items of the FAB-T were found to fit the Rasch Model (Chi-square 16.01(df=20), p = 0.716). Significance: The FAB-T is a reliable and valid tool that can be used to measure balance skills and to identify the source of the problem in children with CP.Publication Metadata only Oxidative Stress, Serum Mineral and Trace Element Levels in Patients with Multiple Sclerosis with or without Restless Legs Syndrome(2024-01-01) Akçin Ş.; Gürsoy A. E.; SELEK Ş.; ÇİMEN Y. A.; KÖKTAŞOĞLU F.; MERAL İ.; ÜSTÜNOVA S.; GÜRSOY, AZIZE ESRA; SELEK, ŞAHABETTİN; ÇİMEN, YASİN ALİ; KÖKTAŞOĞLU, FATMANUR; MERAL, İSMAİL; ÜSTÜNOVA, SAVAŞMultiple sclerosis (MS) is a central nervous system disease characterized by inflammation, axonal demyelination and multifocal plaques. Sleep problems due to restless legs syndrome (RLS) are frequently encountered in MS patients. Changes in oxidative stress level and liver enzyme activity and deterioration of trace element homeostasis are observed in MS and RLS patients. This study was conducted to determine serum oxidative stress parameters and trace element levels in MS patients with and without RLS. Thirty healthy individuals (control), 30 MS patients without RLS (MS group) and 30 MS patients with RLS (MS+RLS group) were included in the study. Serum oxidative stress parameters (total antioxidant and oxidant capacities, myeloperoxidase and catalase activities), some liver enzymes (malate dehydrogenase and isocitrate dehydrogenase) activities, blood trace element (copper, zinc and iron) and mineral (calcium, chlorine, magnesium, sodium, potassium) levels were measured. There was no statistically significant difference between the groups in terms of oxidative stress parameters and liver enzymes. Serum chlorine, potassium and sodium levels were higher in the MS+RLS group compared to the controls (p<0.001, p<0.01, p<0.001, respectively), and the zinc level was lower than the control group (p<0.05). Sodium and chlorine levels were higher in the MS+RLS group than in the MS group (p<0.01, p<0.05, respectively). Based on these results, varying trace element levels may have value for early prediction of RLS in MS. In studies with larger sample sizes, changing element and liver enzyme activities in the context of oxidative stress may provide clearer information about the diagnosis of RLS.