Person: İZZETTİN, FIKRET VEHBI
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Publication Metadata only Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats(2017-09-01T00:00:00Z) Bami, Erliasa; Ozakpinar, Ozlem Bingol; Ozdemir-Kumral, Zarife Nigar; Koroglu, Kutay; ERCAN, FERİHA; CIRAKLI, Zeynep; ŞEKERLER, TURGUT; Izzettin, FİKRET VEHBİ; SANCAR, MESUT; OKUYAN, BETÜL; İZZETTİN, FIKRET VEHBIThis study aims to determine the potential protective effects of ferulic acid against cisplatin-induced nephrotoxicity and to compare its effect with curcumin, a well-known protective agent against cisplatin- induced toxicity in rats. Administration of cisplatin resulted in high BUN (Blood Urea Nitrogen), creatinine, MDA (Malondialdehyde), MPO (Myeloperoxidase), TOS (Total Oxidative Status), PtNT (Protein Nitrotyrosine) levels (p < 0.05). Histological observations showed abnormal morphology of kidney; in addition with appearance of TUNEL positive cells indicating apoptosis in cisplatin administered group. HO-1 (Heme Oxygenase-1) levels measured by RT-PCR (Real Time Polymerase Chain Reaction), and TAS (Total Antioxidative Status) revealed antioxidant depletion due to cisplatin toxicity in animals (p < 0.05). All parameters showed improvement in groups treated with ferulic acid (p < 0.05). Ferulic acid treatment was found significant in preventing oxidative stress, increasing antioxidative status and regaining histological parameters to normal, indicating nephroprotective and antioxidant effects of this phenolic compound.Publication Open Access Determination of Potential Drug-Drug Interactions Using Various Software Programs in a Community Pharmacy Setting(2019-03-01T00:00:00Z) SANCAR, MESUT; Kasik, Aksa; OKUYAN, BETÜL; Batuhan, Sevda; Izzettin, FİKRET VEHBİ; İZZETTİN, FIKRET VEHBIObjectives: The aim of the present study was to compare various software programs in detecting potential drug-drug interactions in a community pharmacy setting. Materials and methods: Details of prescriptions were collected from 50 community pharmacies located in İstanbul in March and April 2015 (two days per week). From each pharmacy, the first 20 prescriptions that included more than one drug were collected to evaluate potential drug-drug interactions. The following software programs were utilized to detect potential drug-drug interactions: micromedexsolutions.com, medscape.com, and drugs.com. The number of potential interactions detected by the software programs was determined. Results: At least one potential drug-drug interaction was detected in 39.2% of the 1000 prescriptions by one of the software programs. According to the rates of total drug-drug interactions gathered from various software programs, these programs gave the following results: medscape.com 33.3%, drugs.com 31.3%, and micromedexsolutions.com 21.2%. Conclusion: After comparing different software programs, the potential drug-drug interactions found by the programs proved to be different. Therefore, we recommend that pharmacists confirm with a different program before making a decision when they detect clinically significant potential drug-drug interactions.Publication Metadata only Comparison of conditioning regimen toxicities among autologous stem cell transplantation eligible multiple myeloma patients: High-dose melphalan versus high-dose melphalan and bortezomib(2018-06-01T00:00:00Z) Aypar, Eda; Izzettin, FİKRET VEHBİ; Aki, Sahika Zeynep; SANCAR, MESUT; Yegin, Zeynep Arzu; Turkoz-Sucak, Gulsan; İZZETTİN, FIKRET VEHBIBackground Autologous hematopoietic stem cell transplantation (AHSCT) remains the standard of care for younger patients with multiple myeloma (MM). Currently, high-dose melphalan (HDM) is recommended as conditioning regimen before AHSCT. Preclinical data suggest that combining bortezomib and melphalan has synergistic effect against multiple myeloma cells. Bortezomib and HDM (Bor-HDM) combination as conditioning regimen has been investigated by many other investigators.Publication Open Access Evaluation of satisfaction and internet self-efficacy of inquirers using an internet-based drug information centre(2019-02-01T00:00:00Z) Izzettin, FİKRET VEHBİ; YILMAZ, ZAHİT; OKUYAN, BETÜL; SANCAR, MESUT; İZZETTİN, FIKRET VEHBIObjectives: This study aimed to evaluate the satisfaction level of inquirers of an internet-based drug information centre along with the internet usage abilities and habits of individuals who had previously utilised services from an internet-based drug information centre in Turkey. Methods: The first 100 individuals who received medication consultancy from the webpage entitled “www.ilacpedia.com” and consented to participate in the study were included in this study. This website is an internet-based drug information centre. Participants' data were collected using a participant data form and the Internet Self-efficacy Scale. Results: The mean age of participants was 37.92 ± 12.32 years (71 female). It was found that 89% of the individuals who received pharmaceutical consultation from the internet-based drug information service believed that the information that they received was enough to solve their problem. The internet self-efficacy scale scores indicated the highest score on the decomposition subscale (20.94 ± 6.18) and the lowest on the communication subscale (9.77 ± 3.57). Conclusions: The present study revealed that the internet-based drug information service provided by clinical pharmacists contributed positively to users' satisfaction, thus indicating the importance of the involvement of clinical pharmacists in this process.Publication Metadata only Erratum to and corrections on the article entitled -Assessment of medication knowledge and adherence among patients under oral chronic medication treatment in community pharmacy settings-(2013-02-01T00:00:00Z) OKUYAN, BETÜL; SANCAR, MESUT; Izzettin, FİKRET VEHBİ; MORISKY, Donald E.; İZZETTİN, FIKRET VEHBIPublication Metadata only Opinion and knowledge towards pharmaceutical care of the pharmacists participated in clinical pharmacy and pharmaceutical care continuing education program Klinik eczaci{dotless}li{dotless}k ve farmasötik baki{dotless}m meslek i̇çi programi{dotless}na kati{dotless}lan eczaci{dotless}lari{dotless}n farmasötik baki{dotless}m hakki{dotless}ndaki bilgi düzeyleri ve görüşleri(2013-08-21T00:00:00Z) SANCAR, MESUT; OKUYAN, BETÜL; Apikoglu-Rabus, Sule; Izzettin, FİKRET VEHBİ; İZZETTİN, FIKRET VEHBIPublication Metadata only A patient-drug profile study in acute myocardial infarction(2010-04-01T00:00:00Z) Erzen, Tayibet; SANCAR, MESUT; Okuyan, Betuel; Izzettin, FİKRET VEHBİ; İZZETTİN, FIKRET VEHBIPublication Metadata only Evaluation of preoperative antibiotic prophylaxis use in a teaching and research hospital in İstanbul İstanbul-daki bir eǧitim ve araşti{dotless}rma hastanesinde preoperatif antibiyotik profilaksisi uygulamasi{dotless}ni{dotless}n deǧerlendirilmesi(2011-12-01T00:00:00Z) Aydin, Hülya; SANCAR, MESUT; Izzettin, FİKRET VEHBİ; İZZETTİN, FIKRET VEHBIPublication Metadata only Assessment of levofloxacin effect on human neutrophil functions in vitro Levofloksasin-in insan Nötrofil fonksiyonlari üzerine etkisinin in vitro deǧerlendirilmesi(2013-06-25T00:00:00Z) Comerter, Hümeyra; KADİR, TANJU; OKUYAN, BETÜL; SANCAR, MESUT; Izzettin, FİKRET VEHBİ; İZZETTİN, FIKRET VEHBIPublication Metadata only Turkish pharmacy technicians- counseling practices and attitudes regarding emergency contraceptive pills(2011-01-01T00:00:00Z) Apikoglu-Rabus, Sule; SANCAR, MESUT; OKUYAN, BETÜL; Izzettin, FİKRET VEHBİ; İZZETTİN, FIKRET VEHBISupplying emergency contraception pills through community pharmacies without the need for a doctor-s prescription is an important public health role for the pharmacy staff, as a way of reducing unwanted pregnancies and induced abortions. Therefore, we aimed to assess the Turkish pharmacy technicians- counseling practices and attitudes regarding emergency contraception pills. A survey tool which was structured to question pharmacy technicians- demography, professional experience, counseling practices and attitudes regarding emergency contraception pills was administered to pharmacy technicians at the end of the -pharmacy technician certification program-. The fully completed questionnaires (n=145) were further analyzed. Mean [SEM] age of the pharmacy technicians was 25.3 [0.4] years and majority (89%) of them were practicing in a community pharmacy. Despite their positive attitude towards the emergency contraception pills, pharmacy technicians were found to provide insufficient emergency contraception pill counseling to clients. We suggest that organization of continuing education programs on -reproductive and sexual health and emergency contraception- for the pharmacy technicians could help increase the quality of emergency contraception pill counseling provided by the pharmacy technicians.