Person: ŞEKERCİ, ABDÜSSELAM
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Publication PREMENOPOZAL KADINLARDA SIK GÖRÜLEN DEMİR EKSİKLİĞİ ANEMİSİNDE SORUN VİTAMİN K EKSİKLİĞİ OLABİLİR Mİ?(2018-10-10T00:00:00Z) KARATOPRAK, CUMALİ; KARAASLAN, TAHSİN; ŞEKERCİ, ABDÜSSELAM; OLGAÇ, ATİLLA; KARATOPRAK, CUMALİ; ŞEKERCİ, ABDÜSSELAMPublication Evaluation of the relationship between vitamin D level and adropin, IL-1β, IL-6, and oxidative status in women(2022-01-01T00:00:00Z) ZORLU, MEHMET; ŞEKERCİ, ABDÜSSELAM; TUNÇ, MUHAMMED; Güler, Eray Metin; Gülen, Bedia; KARATOPRAK, CUMALİ; KISKAÇ, MUHARREM; ÇAKIRCA, MUSTAFA; ZORLU, MEHMET; ŞEKERCİ, ABDÜSSELAM; TUNÇ, MUHAMMED; KARATOPRAK, CUMALİ; KISKAÇ, MUHARREM; ÇAKIRCA, MUSTAFABackground: Vitamin D, adropin, proinflammatory cytokines, and oxidative stress closely related with metabolic homeostasis and endothelial dysfunction. The aim of the present study is to investigate how vitamin D levels affect serum adropin, IL-1ß, IL-6, and oxidative stress. Methods: A total of 77 female subjects were divided into 3 groups according to vitamin D levels. Biochemical parameters, adropin, IL-1ß, IL-6, oxidative stress markers were studied in these groups, and the results were compared statistically. Results: Serum adropin, IL-1ß, IL-6, total oxidant status (TOS) and total antioxidant status (TAS) and oxidative stress index (OSI) levels differed significantly between the vitamin D groups (p < 0.05). A significant positive correlation was detected between vitamin D, and adropin and TAS (r = 0.807; p < 0.001, r = 0.814; p < 0.001, respectively). A significant negative correlation was detected between vitamin D, and IL-1ß, IL-6, TOS, OSI (r = -0.725; p < 0.001, r = -0.720; p < 0.001, r = -0.238; p = 0.037, r = -0.705; p < 0.001, respectively). Discussion: Vitamin D could show its effects through vitamin D receptors on tissues or on the ENHO gene in adropin secreting tissues via direct or indirect mechanisms. Proinflammatory cytokines, oxidative stress, and adropin targeted studies could contribute to the prevention and treatment of diseases associated with vitamin D deficiency in future.Publication COVID-19 and COMORBIDITIES(2020-08-01T00:00:00Z) Şekerci, Abdüsselam; ŞEKERCİ, ABDÜSSELAMA novel coronavirus was identified in Wuhan in December 2019 and it rapidly spread throughout China, followed by in other countries. The aim of this study is to investigate the effects of comorbidities on patients with COVID-19 and to give information about their management. The electronic databases PubMed and Google Scholar have been used to assess comorbidities and clinical characteristics of COVID-19. Severe disease predominantly occurs in adults with underlying medical comorbidities or advanced age. Comorbidities and other conditions that associated with morbidity and mortality include hypertension, diabetes mellitus, cardiovascular disease, chronic lung disease, cancer (particularly metastatic disease, lung cancer, and hematologic malignancies) and chronic kidney disease. As the number of comorbidity increases, patients- clinic progresses more severely. A comprehensive assessment and good management of comorbidities can help patients with COVID-19 achieve a better outcome.Publication Effect of COVID-19 on Emergency Admissions for Young Patients with Ischemic Stroke: An Interrupted Time Series Analysis(2024-01-01) Sümbül Şekerci B.; Pasin Ö.; Yaman Kula A.; Pasin T.; Şekerci A.; SÜMBÜL ŞEKERCİ, BETÜL; PASİN, ÖZGE; YAMAN KULA, ASLI; ŞEKERCİ, ABDÜSSELAMPublication Association between the peripheral blood parameters and Alzheimer’s disease in patients with type-2 diabetes mellitus: a case–control study(2022-10-01T00:00:00Z) Sümbül Şekerci, Betül; Şekerci, Abdüsselam; Gelişin, Özlem; SÜMBÜL ŞEKERCİ, BETÜL; ŞEKERCİ, ABDÜSSELAMPublication Low Serum 25-Hydroxyvitamin D Concentration And Alzheimer-s Disease Risk in Patients with Type-2 Diabetes Mellitus(2022-05-26T00:00:00Z) Sümbül Şekerci, Betül; Gelişin, Özlem; Şekerci, Abdüsselam; SÜMBÜL ŞEKERCİ, BETÜL; ŞEKERCİ, ABDÜSSELAMPublication Could Vitamin K1 Deficiency be the Problem in Iron Deficiency and/or Anemia in Premenopausal Women?(2022-04-01T00:00:00Z) Karatoprak, Cumali; Şekerci, Abdusselam; Karaaslan, Tahsin; Olgaç, Atilla; Özer, Ömer Faruk; Selek, Şahabettin; Köktaşoğlu, Fatmanur; Ekinci, İskender; KARATOPRAK, CUMALİ; ŞEKERCİ, ABDÜSSELAM; ÖZER, ÖMER FARUK; SELEK, ŞAHABETTİNObjective: The etiology of iron deficiency anemia, which develops as a result of menstrual bleeding in the premenopausal period, is unknown. Vitamin K1 has an important role in the coagulation cascade and is not a well known vitamin. The aim of this study was to investigate whether or not Vitamin K1 had a role in anemia developing in the premenopausal period, for which no additional reason could be found. Methods: This study included a patient group of women aged 18-50 years, who had a regular menstrual cycle. Patients who were found to have iron deficiency, who were evaluated hematologically, gastrointestinally and gynecologically, and who did not have a pathology that would lead to iron deficiency were included in the study group.The control group comprised volunteers with regular menstrual cycles who had not been previously determined with iron deficiency. In the study, Vitamin K1, Hemogram, ferritin, iron, total iron binding capacity were examined. The Vitamin K1 level was measured by two different methods both using ELISA and liquid chromatography-mass spectrometry (LC-MS/MS) methods. In addition, a record was made for all participants including demographic characteristics, lifestyle habits, and number of menstruating days. The obtained data were then compared between the groups. Results: A total of 88 voluntary participants were included in the study as 45 patients with iron deficiency anemia (IDA) and a control group of 43 subjects. The age, body mass index, partial thromboplastin, International normalized ratio, active partial thromboplastin time, folic acid, and Vitamin B12 values were similar in both groups. In both methods, no significant difference was determined between the groups in respect of the Vitamin K1 level (p=0.9 in ELISA method and p=0.3 in LC-MS/MS method). The number of menstruation days was determined to be significantly higher in the anemic group than in the control group (p=0.002). Conclusion: From the results of this study, it was considered that IDA developed in premenopausal women with a longer period of menstrual bleeding. However, Vitamin K1 deficiency was not considered to be one of the underlying reasons for longer menstrual bleeding.Publication Diyabet ve Prediyabet Hastalarındaki Kognitif Bozulmanın Hipertrigliseridemi İle İlişkisi(2023-06-14) Şekerci A.; Sümbül Şekerci B.; ŞEKERCİ, ABDÜSSELAM; SÜMBÜL ŞEKERCİ, BETÜLPublication Is there a link between neutrophil-lymphocyte ratio and patient compliance with gluten free diet in celiac disease?(2016-01-01T00:00:00Z) Uslu, Ali Ugur; Korkmaz, Serdal; Yonem, Ozlem; Aydin, Bahattin; Uncu, Tunahan; Sekerci, ABDÜSSELAM; Topal, Firdevs; ŞENCAN, MEHMET; ŞEKERCİ, ABDÜSSELAM© Gülhane Tip Fakültesi 2016.The aim of the present study is to determine the association of neutrophillymphocyte ratio (NLR) as an objective marker for detecting compliance to diet in celiac disease (CD). Thirty-seven patients with CD and 37 healthy volunteers were enrolled to the study. At the end of the first year, the patients were divided into 2 groups considering their compliance with diet. Seven patients, who are not compliant to gluten free diet (GFD), formed the first group (group 1). Thirty patients, who are compliant to GFD, formed the second group (group 2), and 37 healthy volunteers served as the control group (group 3). NLR was significantly higher in the patient group than the controls (p 0.05). At the end of the first year, there were significant differences between group 1 and group 2 (p = 0.007) and between group 1 and group 3 in terms of NLR (p = 0.005). Receiver-operating characteristic curve analysis suggested the optimum NLR cutoff value for patients with GFD incompatible as 2.51, with a sensitivity and specificity of 85 % and 94 %, respectively (area under curve: 0.819, 95 % confidence interval = 0.589-1.000, p = 0.009). NLR may be a promising marker in predicting the patient compliance in patients with CD.Publication Etanercept Kullanımı Sırasında Inh Profilaksisine Rağmen Gelişen Tüberküloz Peritonit(2022-01-04) Uslu Ersöz A. B.; Akkoyunlu Y.; Karakuş H. D.; Şekerci A.; Aslan T.; AKKOYUNLU, YASEMİN; KARAKUŞ, HATİCE DİLARA; ŞEKERCİ, ABDÜSSELAM; ASLAN, TURAN
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