Person: SÜSGÜN, SEDA
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Publication Metadata only DİRENÇLİ NÖBETLER VE KOGNİTİF YIKIM İLE SEYREDEN NADİR BİR METABOLİK-GENETİK NEDEN: SEREBRAL FOLİNİK ASİT EKSİKLİĞİ(2022-05-29T00:00:00Z) Gezegen, Haşim; Süsgün, Seda; Kesim, Yeşim; Salman, Barış; Yücesan, Emrah; Khalilov, Dovlat; Şirin İnan, Nermin Görkem; Gökçay, Gülden Fatma; Baykal, Betül; Uğur İşeri, Sibel Aylin; Bebek, Nerses; SÜSGÜN, SEDA; YÜCESAN, EMRAHPublication Metadata only Two candidate genes with biallelic variants associated with a neurodevelopmental disorder in a consanguineous family from Turkey(2022-06-11T00:00:00Z) Süsgün, Seda; Kesim, Yeşim; Salman, Barış; Yücesan, Emrah; Khalilov, Dovlat; Şirin İnan, Nermin Görkem; Gökçay, Gülden Fatma; Baykal, Betül; Bebek, Nerses; Uğur İşeri, Sibel Aylin; SÜSGÜN, SEDA; YÜCESAN, EMRAHPublication Metadata only İzole servikal distonilerde THAP1, GNAL, KMT2B ve ANO3 genlerine etkiyen miRNA’ların anlatımlarının incelenmesi ve aday biyobelirteç belirlenmesi(2021-12-01T00:00:00Z) Gelişin, Özlem; Süsgün, Seda; Toruntay, Ceyhun; Yabacı Tak, Ayşegül; Baran, Gözde; Gürsoy, Azize Esra; Babacan Yıldız, Gülsen; Yücesan, Emrah; GELİŞİN, ÖZLEM; SÜSGÜN, SEDA; TORUNTAY, CEYHUN; YABACI TAK, AYŞEGÜL; GÜRSOY, AZIZE ESRA; YÜCESAN, EMRAHPublication Metadata only İdiyopatik jeneralize epilepsi tanılı hastalarda miR-132, miR-146a ve miR-155’in biyobelirteç potansiyellerinin incelenmesi(2021-11-28T00:00:00Z) Bayrakoğlu, Alişan; Toruntay, Ceyhun; Süsgün, Seda; Yabacı Tak, Ayşegül; Yücesan, Emrah; Bebek, Nerses; BAYRAKOĞLU, ALİŞAN; TORUNTAY, CEYHUN; SÜSGÜN, SEDA; YABACI TAK, AYŞEGÜL; YÜCESAN, EMRAH; USLU, FERDAPublication Metadata only Otozomal Resesif Nörogelişimsel Bozukluğun Nedeni Olarak Bi-alelik NALCN Varyantı(2020-11-30T00:00:00Z) Süsgün, Seda; Göncü, Beyza; Kına, Ümit Yaşar; Hasanoğlu, Sevde; Özgül, Cemil; Çalık, Mustafa; Özbek, Uğur; Uğur İşeri, Sibel Aylin; SÜSGÜN, SEDA; YÜCESAN, EMRAH; GÖNCÜ, BEYZA SERVET; KINA, ÜMİT YAŞARPublication Metadata only Possible effects of caffeic acid phenethyl ester and thymoquinone against toluene brain injury(2019-08-31T00:00:00Z) MEYDAN, SEDAT; EŞREFOĞLU, MUKADDES; SELEK, ŞAHBETTİN; AKBAŞ TOSUNOĞLU, ESRA; öztürk, özlem; kurbetli, nuriye; BAYINDIR, NİHAN; BULUT, HURİ; MERAL, İSMAİL; SÜSGÜN, SEDA; AKBAŞ, FAHRİ; MEYDAN, SEDAT; EŞREFOĞLU, MUKADDES; SELEK, ŞAHABETTİN; MERAL, İSMAİL; SÜSGÜN, SEDA; AKBAŞ, FAHRİPublication Metadata only Miyelodisplastik sendromda miR145/146a-nın TGF- ß sinyal yolağındaki rolü ve 5q delesyonu ile ilişkisinin incelenmesi(2019-10-30T00:00:00Z) Süsgün, Seda; SÜSGÜN, SEDAPublication Metadata only Fibromiyalji Sendromu ile Bağırsak Mikrobiyotası Arasındaki İlişkinin Araştırılması(2020-12-31T00:00:00Z) Albayrak, Büşra; Süsgün, Seda; Küçükakkaş, Okan; Akbaş, Fahri; Yabacı, Ayşegül; Özçelik, Semra; SÜSGÜN, SEDA; KÜÇÜKAKKAŞ, OKAN; AKBAŞ, FAHRİ; YABACI TAK, AYŞEGÜLFibromyalgia syndrome (FMS) is one of the frequent forms of chronic widespread pain, with a reported prevalence of 2% to 4% in the adult population. Nervous system dysfunction is implicated in FMS and neurotransmitters are the targets of a number of drugs approved for fibromyalgia. However exact underlying mechanisms of FMS are unknown yet and multiple hypotheses being suggested. Considering the relation between fibromyalgia and irritable bowel syndrome, altered gut microbiome could be associated with fibromyalgia. Herein, altered gut microbiome levels were investigated in patients with FMS compared to healthy controls. We collected faeces to study the microbiome, from a cohort of 54 patients with FMS and 36 healthy individuals. Extraction of DNA was carried out with commercial kit according to the manufacturer’s recommendations. Samples were compared using 16S rRNA gene amplification with specific primers of Bacteroidetes, Firmicutes, Enterobacteria, Lactobacillus, Streptococcus and Bifidobacterium by the Real-Time PCR instrument. According to our results, Bacteroidetes and Bifidobacteria were increased statistically significant (p<0.05), Firmicutes was decreased (p<0.001) in the patient group. No statistically significant results were found for Enterobacterium, Streptococcus and Lactobacillus (p>0.05). When the relationship between bacteria was evaluated, statistically significant and negative correlation was found between Bacteroidetes and Firmicutes percentage (r =-0.778, p <0.001). A moderately positive correlation was observed between the percentage of Enterobacter and Bifidobacter (r = 0.460, p = 0.005). The results suggest that the gut microbiota may play a role in fibromyalgia.t the gut microbiota may play a role in fibromyalgia. In sum, it is clear that large-scale further research in larger cohorts will be efficient in understanding the relationship of gut microbiome and FMS and evaluating possible treatment options.Publication Metadata only Eksüdatif yaşa bağlı makula dejenerasyonunun etiyopatogenezinin aydınlatılması amacıyla ARPE-19 hücre hattında CoCl2 ile indüklenen hipoksi modeli oluşturulması(2021-10-31T00:00:00Z) Süsgün, Seda; Korkmaz, Nur Damla; Kutlutürk, Işıl; Akbaş, Fahri; Özdemir, Mehmet Hakan; Elbay, Ahmet; SÜSGÜN, SEDA; KORKMAZ, NUR DAMLA; AKBAŞ, FAHRİ; ÖZDEMİR, MEHMET HAKAN; ELBAY, AHMETPublication Metadata only Novel WDR45 frameshift variant detected by whole-exome sequencing in beta-propeller protein-associated neurodegeneration disease(2021-08-28T00:00:00Z) SÜSGÜN, SEDA; DEMİREL, MERT; YALÇIN ÇAKMAKLI, GÜL; ELİBOL, BÜLENT; UĞUR İŞERİ, SİBEL AYLİN; YAPICI, ZÜHAL; SÜSGÜN, SEDA