Person: BAŞARANOĞLU, GÖKÇEN
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Publication Open Access Ovaries are more vulnerable than hepatocytes for insulin resistance and hyperinsulinemia(2016-01-01) GULTEPE, Ilhami; Basaranoglu, METİN; SULEYMANOGLU, Yaser; Basaranoglu, GÖKÇEN; BEYAZIT, Fatma; BAŞARANOĞLU, METİN; BAŞARANOĞLU, GÖKÇENBackground/Aims: Non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) are common metabolic disorders. We aimed to evaluate the underlying mechanisms in the development of NAFLD and PCOS.Publication Open Access Role of Discipline and Educational Method on Vocational High School Students- Success in an Anesthesia Course(2015-04-01) Basaranoglu, GÖKÇEN; Basaranoglu, METİN; BAŞARANOĞLU, GÖKÇEN; BAŞARANOĞLU, METİNObjective: The goal of this study is to reveal the relationship between discipline and teaching method and between vocational high school technical students' success in an anesthesia course and levels of following the lessons. Methods: A questionnaire was filled out by first-year technical students in an anesthesia course for situational awareness evaluation at the beginning of the term. Oral presentations were supported by catechetics, reward systems, etc. to ensure active participation. Results: While the students' success rate was 91.9%, the dissatisfaction rate was 4%. The students stated that they were most satisfied (100%) with the rewarding part of the theoretical lessons. Conclusion: Anesthesiology requires discipline for achieving success. Students' course success on anesthesia can be enhanced using a student-centered learning and reward system.Publication Metadata only The evaluation of brain natriuretic peptide changes and difficult airway predictors during perioperative period of pregnancy(2016-02-01) Basaranoglu, GÖKÇEN; UMUTOGLU, T.; BAKAN, M.; ESEN, ASIM; ATES, SEDA; BACAKSIZ, AHMET; SALIHOGLU, Z.; BAŞARANOĞLU, GÖKÇEN; ESEN, ASIM; ATEŞ, SEDA; BACAKSIZ, AHMETAim Airway changes, difficult ventilation, and intubation are the leading causes of morbidity and mortality in pregnancy, but no prospective study has evaluated the relationship between airway changes and brain natriuretic peptide (BNP) before and after cesarean section operations. The purpose of this study was to evaluate the relationship between BNP and airway changes in women undergoing delivery and during the postoperative period.Publication Metadata only Regional block anesthesia in a patient with factor V Leiden mutation and axillary artery occlusion.(2011-01-01T00:00:00Z) ERKALP, K; COMLEKCI, M; INAN, BEKİR; Basaranoglu, GÖKÇEN; OZDEMIR, HÜSEYİN; SAIDOGLU, L; İNAN, BEKİR; BAŞARANOĞLU, GÖKÇENPublication Open Access Temporary vision loss after spinal anesthesia(2015-01-01) BAŞARANOĞLU, GÖKÇEN; IDIN, KADIR; UMUTOGLU, TARIK; TOPUZ, UFUK; ESEN, ASIM; UYSAL, HARUN; BAŞARANOĞLU, GÖKÇEN; UYSAL, HARUNPerioperative visual loss is a rare complication mostly associated with cardiac, spine, and head and neck surgery that could severely affect quality of life. We report a case of temporary visual loss without any other subjective symptom after spinal anesthesia.Publication Metadata only Laryngeal subglottic web in a parturient(2014-09-01) Basaranoglu, GÖKÇEN; UMUTOGLU, T.; BAKAN, M.; VEYSELLER, B.; SALIHOGLU, Z.; BAŞARANOĞLU, GÖKÇENPublication Open Access From fatty liver to fibrosis: A tale of -second hit-(2013-02-28) Basaranoglu, METİN; Basaranoglu, GÖKÇEN; Senturk, HAKAN; BAŞARANOĞLU, METİN; BAŞARANOĞLU, GÖKÇEN; ŞENTÜRK, HAKANAlthough much is known about how fat accumulates in the liver, much remains unknown about how this causes sustained hepatocellular injury. The consequences of injury are recognized as nonalcoholic steatohepatitis (NASH) and progressive fibrosis. The accumulation of fat within the hepatocytes sensitizes the liver to injury from a variety of causes and the regenerative capacity of a fatty liver is impaired. An additional stressor is sometimes referred to as a “second hit” in a paradigm that identifies the accumulation of fat as the “first hit”. Possible candidates for the second hit include increased oxidative stress, lipid peroxidation and release of toxic products such as malondialdehyde and 4-hydroxynonenal, decreased antioxidants, adipocytokines, transforming growth factor (TGF)-β, Fas ligand, mitochondrial dysfunction, fatty acid oxidation by CYPs (CYP 2E1, 4A10 and 4A14), and peroxisomes, excess iron, small intestinal bacterial overgrowth, and the generation of gut-derived toxins such as lipopolysaccharide and ethanol. Oxidative stress is one of the most popular proposed mechanisms of hepatocellular injury. Previous studies have specifically observed increased plasma and tissue levels of oxidative stress markers and lipid peroxidation products, with reduced hepatic and plasma levels of antioxidants. There is also some indirect evidence of the benefit of antioxidants such as vitamin E, S-adenosylmethionine, betaine, phlebotomy to remove iron, and N-acetylcysteine in NASH. However, a causal relationship or a pathogenic link between NASH and oxidative stress has not been established so far. A number of sources of increased reactive oxygen species production have been established in NASH that include proinflammatory cytokines such as tumor necrosis factor (TNF)-α, iron overload, overburdened and dysfunctional mitochondria, CYPs, and peroxisomes. Briefly, the pathogenesis of NASH is multifactorial and excess intracellular fatty acids, oxidant stress, ATP depletion, and mitochondrial dysfunction are important causes of hepatocellular injury in the steatotic liver.Publication Metadata only The Effect of Nicotine Treatment on Propofol Injection Pain(2010-03-01T00:00:00Z) ERDEN, Veysel; Basaranoglu, GÖKÇEN; ERKALP, Kerem; YANGIN, Zehra; DELATIOGLU, Hamdi; TEKER, M. Goekhan; SAITOGLU, Leyla; BAŞARANOĞLU, GÖKÇENObjectives: Smokers had higher risk than nonsmokers for pain. The incidence of pain on injection of propofol has been reported to be 70%. We explored the relationship between smoking habits and propofol injection pain, whether nicotine replacement has an influence on intensity or incidence of pain associated with propofol in smokers.Publication Metadata only Peripartum management of a pregnant with Glanzmann’s thrombasthenia: A case report Glanzmann trombastenili gebenin peripartum dönemde yönetimi: Olgu sunumu(2014-01-01) ATEŞ, SEDA; MOLLA, Taner; ÖZKAL, Fulya; ÇETİN, GÜVEN; BAŞARANOĞLU, GÖKÇEN; Dane, Banu; ATEŞ, SEDA; ÇETİN, GÜVEN; BAŞARANOĞLU, GÖKÇENPublication Open Access Inadvertent Venous Air Embolism during Cesarean Section: Collapsible Intravenous Fluid Bags Without Self-Sealing Outlet Have Risks. Case Report(2013-07-01) BAKAN, Mefkur; TOPUZ, Ufuk; Esen, ASIM; Basaranoglu, GÖKÇEN; OZTURK, Erdogan; ESEN, ASIM; BAŞARANOĞLU, GÖKÇENThe anesthesiologist must be aware of the causes, diagnosis and treatment of venous air embolism and adopt the practice patterns to prevent its occurrence. Although venous air embolism is a known complication of cesarean section, we describe an unusual inattention that causes iatrogenic near fatal venous air embolism during a cesarean section under spinal anesthesia. One of the reasons for using self-collapsible intravenous (IV) infusion bags instead of conventional glass or plastic bottles is to take precaution against air embolism. We also demonstrated the risk of air embolism for two kinds of plastic collapsible intravenous fluid bags: polyvinyl chloride (PVC) and polypropylene-based. Fluid bags without self-sealing outlets pose a risk for air embolism if the closed system is broken down, while the flexibility of the bag limits the amount of air entry. PVC-based bags, which have more flexibility, have significantly less risk of air entry when IV administration set is disconnected from the outlet. Using a pressure bag for rapid infusion can be dangerous without checking and emptying all air from the IV bag.