Person:
GÖKÇE, MUSTAFA

Profile Picture

Status

Organizational Units

OrgUnit Logo
Organizational Unit

Job Title

First Name

MUSTAFA

Last Name

GÖKÇE

Name

Email Address

Birth Date

Filters

2019 - 201942020 - 20238
Reset filters

Settings

Search Results

Now showing 1 - 10 of 12
  • Thumbnail Image
    Publication
    An Overview of COVID-19 Medicines in Current Guidelines
    (2020-12-01T00:00:00Z) GÖKÇE, MUSTAFA; GÜLER, ERAY METİN; GÖKÇE, MUSTAFA; GÜLER, ERAY METİN
    An acute respiratory disease caused by a new coronavirus (Severe acute respirotary syndrome-coronavirus-2, previously known as 2019-nCoV), coronavirus disease 2019 (COVID-19), appeared in December 2019 and then has spread rapidly throughout the world starting from China, Japan and South Korea. As of January 30, 2020, the World Health Organization has officially declared the COVID-19 outbreak. Considering the clinical symptoms of COVID-19, it has many symptoms such as high fever, cough, and fatigue. It is reported that this disease is very severe and causes serious consequences such as cytokine storm and acute respiratory distress syndrome in the elderly and those with chronic diseases. Currently, scientists are trying to find a specific antiviral treatment strategy. Various medications such as hydroxychloroquine, lopinavir/ritonavir, ribavirin, remdesivir and favipiravir are currently being applied in clinical trials to test their efficacy and safety worldwide in COVID-19 treatment, and some promising results have been achieved so far. In this review, agents with potential efficacy against COVID-19 are presented in summary.
  • No Thumbnail Available
    Publication
    ASSOCIATION OF PLASMA DIAZEPAM BINDING INHIBITOR WITH INFLAMMATORY, OXIDATIVE STRESS AND NEURODEGENERATIVE MARKERS IN ALZHEIMER-S DISEASE
    (2021-11-06T00:00:00Z) Gökçe, Mustafa; Bektay, Muhammed Yunus; Velioğlu, Halil Aziz; Güler, Eray Metin; GÖKÇE, MUSTAFA; BEKTAY, MUHAMMED YUNUS
  • No Thumbnail Available
    Publication
    Hepatoselüler Karsinoma, Mide ve Kolorektal Kanser Hastalarında Tedavi Öncesi ve Sonrası Oksidatif Stresin Araştırılması
    (2019-10-01) Bozbulut, Elif; GÖKÇE, MUSTAFA; BEKTAY, MUHAMMED YUNUS; Serilmez, Murat; Uzun, Mustafa; Aksoy, Turgut; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; GÖKÇE, MUSTAFA; BEKTAY, MUHAMMED YUNUS; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN
  • No Thumbnail Available
    Publication
    Temel Mitokondriyal Tıp
    (2019-01-01T00:00:00Z) GÖKÇE, MUSTAFA; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; GÖKÇE, MUSTAFA; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN
  • No Thumbnail Available
    Publication
    GLP-1 RESEPTÖR AGONİSTİ LİRAGLUTİD'İN İNSAN ENDOTEL HÜCRELERİNDE YÜKSEK GLUKOZ İLE İNDÜKLENEN İNFLAMASYON İLE İLİŞKİLİ SİNYAL YOLAKLARI ÜZERİNE ETKİSİ
    (2023-11-25) Gökçe M.; Vidin Şen A.; Öztürk Civelek D.; Uydeş Doğan B. S.; Alp Yıldırım F. İ.; GÖKÇE, MUSTAFA; ÖZTÜRK CİVELEK, DİLEK
    Amaç: Diabetes Mellitus’a bağlı olarak gelişen endotel disfonksiyonu, değişen hücre sinyalizasyonu, artan oksidatif stres ve proinflamatuvar süreçlerin aktivasyonu temelinde diyabete bağlı vasküler komplikasyonların en önemli nedenidir. İnflamasyona zemin hazırlayan immün yanıtta önemli bir rol oynayan ve patern tanıma reseptörlerinin bir üyesi olan NODbenzeri-reseptör-3 (NLRP3), inflamatuvar kaspazların aktivasyonunu, pro-interlökin-18 ve pro-interlökin-1β\"nın işlenmesini sağlayan bir protein kompleksidir. NLRP3, ASC/TMS1 ve Kaspaz-1 NLRP3 inflamazom kompleksini oluşturmaktadır. Bu çalışmada, insan endotel hücre kültürlerinde GLP-1 reseptör (GLP-1R) agonisti Liraglutid’in inflamasyona zemin hazırlayan immün yanıt yolakları ile ilişkili hedef moleküller üzerine etkisinin araştırılması amaçlanmıştır. Gereç-Yöntem: HUVEC (İnsan umbilikal ven endotel hücreleri) ve HCAEC (İnsan koroner arter endotel hücreleri), normoglisemik (5.5mM) veya hiperglisemik ortamda (25 mM) 48 saat boyunca Liraglutid’in 10 nM ve 100 nM lik konsantrasyonları ile inkübe edilmiştir. Ardından LDH (laktat dehidrogeneaz) testi ile canlılık tayini yapılmıştır. RT-PCR testi ile NLRP3 inflamazom kompleksinin üyeleri olan ASC/TMS1 ve Kaspaz-1 mRNA ekspresyonları ölçülmüştür. Bulgular: HUVEC’de LDH seviyelerinde anlamlı bir değişikliğe neden olmamasına karşın Liraglutid 100 nM’de LDH seviyelerini azaltmıştır. Hiperglisemik ortam HUVEC’de Kaspaz-1 mRNA düzeylerinde artışa neden olmuşken HCAEC’de bir değişim olmamıştır. Liraglutid 10 nM’de, HCAEC’de hiperglisemi ile artan Kaspaz-1 mRNA düzeylerini baskılarken, HUVEC’de etkisiz bulunmuştur. ASC/TMS1 mRNA düzeyleri HUVEC’de hiperglisemik ortamda artarken, HCAEC’de anlamlı bir değişime neden olmamıştır. HCAEC’de ASC/TMS1 mRNA düzeylerinde gözlenen söz konusu artış Liraglutid varlığında azalırken (10 nM’de) HUVEC’de Liraglutid inkübasyonu ile bir değişiklik olmamıştır. Sonuç: Bu çalışmanın sonuçları, Liraglutid\"in insan kaynaklı venöz ve arteriyel endotel hücrelerinde hiperglisemi ile indüklenen inflamasyon ve immün yanıt aktivasyonuna bağlı olarak oluşan hücresel hasarı azaltma potansiyelinin olabileceğine işaret etmektedir. Anahtar Kelimeler: Endotel, İnflamasyon, Liraglutid, NLRP3, Hiperglisemi
  • Thumbnail Image
    Publication
    Investigation of the Genotoxic, Cytotoxic, Apoptotic, and Oxidant Effects of Olive Leaf Extracts on Liver Cancer Cell Lines
    (2021-03-01T00:00:00Z) Guler, Eray Metin; Gökçe, Mustafa; Kızıltaş, Mustafa Volkan; BEKTAY, MUHAMMED YUNUS; GÖKÇE, MUSTAFA
    Objectives: Hepatocellular carcinoma (HCC) is the seventh most common cancer and the third leading cause of tumor-related deaths worldwide. Mechanisms underlying tumor onset, progression, and metastasis in the case of HCC have not been adequately studied. In this study, we aimed to investigate the genotoxic, cytotoxic, apoptotic and oxidant effects of olive leaf extract (OLE) on HCC cells. Materials and methods: H4IIE Rattus norvegicus hepatoma cells and Rattus norvegicus healthy liver clone-9 cells were treated with the increasing concentrations of OLEs (250-2000 ppm) in ethanol, acetone, dichloromethane, and methanol. ATP cell viability, intracellular reactive oxygen species generation levels, double staining test with acridine orange/ethidium bromide, comet assay, levels of interleukin 1-beta (IL-1β), IL-6, and tumor necrosis factor alpha were measured. Significance was determined using ANOVA test. Results: Apoptotic, genotoxic, cytotoxic, and oxidative effects of OLEs increased with the increasing concentrations as compared to controls in H4IIE cells (p<0.001). Conclusion: This is the first study to show a significant and selective cytotoxic activity of OLEs in the selected H4IIE cancer cell lines. OLEs could selectively increase the apoptotic damage and show anti-proliferative and pro-apoptotic properties against the H4IIE cells. They could be recommended as potential nutraceuticals in the prevention of cancer.
  • No Thumbnail Available
    Publication
    A. hierchuntica extract exacerbates genotoxic, cytotoxic, apoptotic and oxidant effects in B16F10 melanoma cells
    (2021-07-30T00:00:00Z) GÖKÇE, MUSTAFA; Guler, Eray Metin; GÖKÇE, MUSTAFA
    © 2021 Elsevier LtdMelanoma is a highly malignant tumor caused by melanocytes. Even though melanoma represents just 3% of all skin malignancies, it represents 75% of deaths. Extracts of A. hierchuntica were reported to have anti-inflammatory, hepatoprotective, and anti-melanogenic activities. This study aims to investigate the dose-related relationship and selectivity of the toxic effects of A. hierchuntica extracts (AHE) on melanoma cells and provide a new option that can be used in the future treatment of melanoma. B16F10 Mus musculus malign melanoma cells and L929 Mus musculus healthy fibroblast cells were treated with root and leaf AHEs in a dose-dependent manner. Intracellular glutathione levels, mitochondrial membrane potential activity, apoptosis, genotoxicity, and cytotoxicity of AHE were evaluated. This study is probably the first study to show a significant apoptotic and genotoxic activity of AHE in selected B16F10 cancer cell lines. Mitochondrial membrane potential and glutathione activity of B16F10 and L929 melanoma cells decreased with increasing concentrations of both leaf and root AHEs. However, viability and reactive oxygen species levels showed selectivity especially the AHEs concentrations between 400 μg/mL and 500 μg/mL. This selectivity based on doses was also validated in apoptosis and genotoxicity between healthy and cancer cells (p < 0.001). The results showed that when looking at melanoma-specific, AHE could be a source of inspiration as an active ingredient in future treatment protocols. AHE can be recommended as potential nutraceuticals in the prevention of human melanoma cancer.
  • No Thumbnail Available
    Publication
    Urotensin-II, oxidative stress, and inflammation increase in hypertensive and resistant hypertensive patients.
    (2020-11-11T00:00:00Z) Guler, Eray Metin; Gokce, MUSTAFA; Bacaksiz, A; Kocyigit, ABDÜRRAHİM; GÜLER, ERAY METİN; GÖKÇE, MUSTAFA; KOÇYİĞİT, ABDÜRRAHİM
  • Thumbnail Image
    Publication
    Evaluating the Clinical Significance of Diazepam Binding Inhibitor in Alzheimer's Disease: A Comparison with Inflammatory, Oxidative, and Neurodegenerative Biomarkers.
    (2023-08-22) Gokce M.; Velioglu H. A.; Bektay M. Y.; Guler E. M.; GÖKÇE, MUSTAFA; BEKTAY, MUHAMMED YUNUS
    Introduction: Alzheimer's disease (AD) is one of the pathologies that the scientific world is still desperate for. The aim of this study was the investigation of diazepam binding inhibitor (DBI) as a prognostic factor for AD prognosis. Methods: A total of 120 participants were divided into 3 groups. Forty new diagnosed Alzheimer patients (NDG) who have been diagnosed but have not started AD treatment, 40 patients who diagnosed 5 years ago (D5YG), and 40 healthy control groups (CG) were included in the study. Levels of DBI, oxidative stress, inflammatory, and neurodegenerative biomarkers were compared between 3 groups. Results: Plasma levels of DBI, oligomeric Aβ, total tau, glial fibrillary acidic protein, α-synuclein, interleukin (IL) 1β, IL6, tumor necrosis factor α, oxidative stress index, high-sensitive C-reactive protein, and DNA damage were found higher in D5YG and NDG as compared to CG (p < 0.001). On the contrary, plasma levels of total thiol, native thiol, vitamin D and vitamin B12 were lower in D5YG and NDG as compared to CG (p < 0.001). Discussion: DBI may be a potential plasma biomarker and promising drug target for AD. It could help physicians make a comprehensive evaluation with cognitive and neurodegenerative tests.
  • No Thumbnail Available
    Publication
    INVESTIGATION OF THE ASSOCIATOIN BETWEEN POLYPHARMACY AND ALZHEIMER DISEASE
    (2019-10-25) BEKTAY, MUHAMMED YUNUS; YILDIZ, GÜLSEN; BOLAT, ERKUT; SELVİTOP, RABİA; GÖKÇE, MUSTAFA; BEKTAY, MUHAMMED YUNUS; GÖKÇE, MUSTAFA