Person: KARATOPRAK, CUMALİ
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Publication Open Access Effect of transfusion of washed red blood cells on serum potassium level in hemodialysis patients(2017-01-01) DEMIRTUNC, Refik; OZENSOY, Ugur; CETINKAYA, Fuat; KAYATAS, Kadir; USTUN, Emel; Kazancioglu, RÜMEYZA; KARATOPRAK, CUMALİ; KARATOPRAK, CUMALİ; KAZANCIOĞLU, RÜMEYZABackground/aim: This study aimed to compare washed red blood cell (WRBC) transfusion versus nonwashed RBC (NWRBC) transfusion in terms of posttransfusion potassium levels in dialysis patients on a day when the patient did not receive dialysis. Materials and methods: The patients were randomly assigned into two groups, i.e. those receiving WRBCs (n = 21) and those receiving NWRBCs (n = 17). Both groups received one unit of RBCs. Serum potassium and sodium levels were measured before and at the 1st, 2nd, 3rd, 4th, and 6th hours after transfusion. Results: In the WRBC group, the changes in the serum potassium levels at the 3rd, 4th, and 6th hours after transfusion were significant compared with pretransfusion levels. In the serum potassium levels mean decreases by 0.38 ± 0.57 mEq/L at the 3rd hour (P = 0.006), by 0.32 ± 0.47 mEq/L at the 4th hour (P = 0.005), and by 0.32 ± 0.51 mEq/L at the 6th hour (P = 0.009) after transfusion were significant compared with the pretransfusion levels. Conclusion: Although nonwashed RBC transfusion does not change serum potassium levels, washed RBC transfusion significantly reduces serum potassium levels. Washed RBC transfusion is considered to be safer in hemodialysis patients with hyperkalemia and anemia.Publication Open Access CD40 ligand and P-selectin in heterozygous Beta-thalassemia(2016-06-01) CIKRIKCIOGLU, Mehmet Ali; SOYTAS, Rabia Bag; KILIC, Elif; Toprak, Aybala Erek; Karatoprak, CUMALİ; Zorlu, MEHMET; Kiskac, MUHARREM; EMEGIL, Sebnem; Cetin, GÜVEN; Dogan, ELİF ECE; SEKIN, Yahya; HAMDARD, Jamshid; ÇAKIRCA, MUSTAFA; ZORLU, MEHMET; KISKAÇ, MUHARREM; ÇETİN, GÜVEN; DOĞAN, ELİF ECE; KARATOPRAK, CUMALİObjective: To investigate platelet functions and measure soluble CD40 ligand, soluble P-selectin, beta-thromboglobulin and platelet factor 4 levels in the blood of heterozygous beta thalassemia patients. Methods: The cross-sectional case-control study was conducted at Bezmialem Vakif University, Istanbul, Turkey, between September 2013 and April 2014, and comprised heterozygous beta thalassemia patients who were compared with 41 gender-, age- and body mass index-matched controls for platelet function markers. The two groups were also compared for co-morbidities, smoking, and regular medications. Results: Of the 78(78.78) subjects, 50(64%) were women and 28(36%) men with an overall mean age of 39.4±12.7 years (range: 18-79 years). The mean body mass index was 26.3±4.2. The heterozygous beta thalassemia group included 37(47%) subjects [24(65%) females; 13(35%) males] while the control group had 41(53%) [26(63%) females; 15(37%) males]. Soluble CD40 ligand and soluble P-selectin were lower in the heterozygous beta thalassemia group (p=0.009; p=0.010). Beta-thromboglobulin and platelet factor 4 levels were comparable between the groups (p=0.497; p=0.507.). Conclusions: Some platelet functions may be reduced in heterozygous beta thalassemia patients, which may be related to their lower incidence of cerebral and cardiac ischaemic events.Publication Open Access Serum endocan levels in women with restless legs syndrome.(2015-11-19) CELIK, K; ÇıKRıKÇıOĞLU, MA; HALAC, G; KILIC, ERDEM; AYHAN, S; OZARAS, N; Karatoprak, CUMALİ; YILDIZ, KEMALETTİN; YILDIZ, RS; ZORLU, MEHMET; CAKIRCA, MUSTAFA; KıSKAÇ, MUHARREM; KILIÇ, ERDEM; YILDIZ, KEMALETTİN; ZORLU, MEHMET; KARATOPRAK, CUMALİ; ÇAKIRCA, MUSTAFA; KISKAÇ, MUHARREMBackground: Endocan is a recently introduced marker of endothelial dysfunction. The objective of this study was to compare serum endocan levels in patients with restless legs syndrome (RLS) and control subjects in order to elucidate whether RLS is associated with endothelial dysfunction. Methods: A total of 31 drug naïve female patients with RLS and 31 age- and BMI-matched women were included in the study. Patients with pathological or physiological conditions or with a history of medication use that could potentially influence endothelial functions were excluded, as well as those with alcohol or drug abuse history. The two groups were compared with routine blood tests and serum endocan levels. Results: Patients with RLS had lower serum endocan levels than the controls (P=0.037). There was a negative bivariate correlation between RLS severity score and serum endocan levels (r=-0.406, P=0.023). While white blood cell count was significantly higher in RLS group, 25-hydroxy vitamin D3, vitamin B12, transferrin saturation rate, and HDL-cholesterol were significantly lower. Creatininemia and diastolic blood pressure were also marginally insignificantly lower in RLS group. Due to the presence of differences between two groups in these variables, a linear regression analysis was performed that showed a positive association between endocan and creatininemia (β=0.310, P=0.022), and a negative association between endocan and RLS (β=-0.502, P,0.001). Conclusion: The results of this study seem to suggest that patients with RLS may have better endothelial functions when compared with the general population and that these patients may be better protected against atherosclerosisPublication Metadata only Dirençli Hipertansiyonlu Hastalarda H. Pylori Sıklığı Ve H. Pylori Eradikasyonun Yüksek Kan Basıncı Üzerine Etkisi.(2017-10-14T00:00:00Z) Karatoprak, Cumali; Hamdard, Jamshid; Bacaksız, Ahmet; KARATOPRAK, CUMALİ; BACAKSIZ, AHMETAims: Helicbacter pylorinin (H. pylori) ekstraintestinal olarak birçok patolojiye neden olduğu bilinmektedir. H. pylori eradikasyonunun primer hipertansiyon üzerinde pozitif etkileri olduğunu gösteren çalışmalar mevcuttur. Bu çalışmada biri diüretik olmak üzere 3 antihipertansif ilaç kullanımına rağmen sistolik kan basıncının >140 mm-Hg ve diyastolik kan basıncının >90 mm-Hg olan dirençli hipertansif hastalarda H. pylori sıklığı ve eradikasyonun kan basıncı kontrolü üzerine etkisi araştırılmıştır.Materials and Methods: Bu çalışma prospektif gözlemsel bir çalışmadır. Hastalardan gaitada H.pylori antijeni bakılan ve dirençli hipertansiyonu olan hastalar toplandı. Bütün hastaların ambulatuvar kan basınç monitörizasyonu ile 24 saatlik kan basınçları ölçüldü ve ortalama kan basıncı sistolik 140 mmhg ve/veya diastolik 90 mm-Hg’nın üzerinde olan hastalar çalışmaya alındı. Çalışmaya uygun bulunan hastalar H.pylori pozitif olanlar bir grup negatif olanlar diğer grup olmak üzere ikiye ayrıldı. H. pylori antijeni negatif olan hastalarda tedaviye uyum, tuzsuz beslenme ve kilo vermenin önemi anlatılarak 6 hafta sonra kontrole çağrıldı ve 24 saatlik kan basıncı monitorizasyonu tekrar yapıldı. H. pylori antijeni pozitif olan hastalara 14 günlük standart (lansoprozol, amoksisilin ve klaritromisin) H. pylori eradikasyon tedavisi verildi. Eradikasyon tedavisi bittikten 4 hafta sonraki kontrollerinde dışkıda H. pylori antijeni negatif olanlarda eradikasyon başarılı kabul edildi. Dirençli esansiyel hipertansiyonlu hastalarda 6 haftalık aralarla elde edilen sistolik ve diyastolik kan basınçları karşılaştırıldı.Results: Çalışmaya 12 H. pylori (+) 37 H. pylori (-) olmak üzere toplam 49 hasta katılmıştır.Bu çalışmada H. pylori sıklığı %24.5 bulunmuştur. H.pylori (+) hastalar tedavi edildiğinde hem sistolik (26.7 mm-Hg) hemde diastolik (9 mm-Hg) kan basıncında anlamlı düşüşler gözlenmiştir (P=0.002, P=0.011 respectively). Diğer taraftan H.pylori (-) olanlarda tedavi uyumunun arttırılmasına yönelik önerilere rağmen hem sistolik (-0.5 mm-Hg) hem de diastolik (0.3 mm-Hg) kan basıncında anlamlı bir değişiklik olmamıştır (P=0.52, P=0.73, sırasıyla). Conclusion: Bu sonuçlar direçli hipertansiyonu olan hastalarda H. pylori aranması gerektiğini düşündürmektedir. Ve eğer H. pylori pozitif saptanırsa eradikasyon tedavisinin arterial kan basıncı kontrolunu sağlamada yardımcı olabileceğini düşündürmektedir.Publication Open Access Association of calcium channel blocker use with lower hemoglobin levels in chronic kidney disease(2013-09-01) Karatoprak, CUMALİ; CIKRIKCIOGLU, M. A.; Cakirca, MUSTAFA; Kiskac, MUHARREM; Zorlu, MEHMET; Cetin, GÜVEN; YILDIZ, KEMALETTİN; ERKOC, R.; ALAY, M.; Erkal, S.; Erkal, S. N.; DOGAN, S.; Kazancioglu, RÜMEYZA; KARATOPRAK, CUMALİ; ÇAKIRCA, MUSTAFA; KISKAÇ, MUHARREM; ZORLU, MEHMET; ÇETİN, GÜVEN; YILDIZ, KEMALETTİN; KAZANCIOĞLU, RÜMEYZAAim: To search whether calcium channel blockers (CCBs) are associated with lower hemoglobin levels in chronic kidney disease (CKD) patients who are not on renal replacement therapy (RRT), vitamin D and anti-anemic treatment. Patients and methods: CKD patients were classified into two groups. Patients on CCBs treatment (103 patients) and patients not using CCBs (104 patients) were compared cross-sectionally regarding clinical findings, complete blood count (CBC), biochemistry and regular medication use. Patients with polycystic kidney disease, comorbidities that could influence CBC other than iron deficiency of obscure origin, patients receiving RRT, erythropoietin (EPO), vitamin D, phosphate binders and drugs that could influence CBC were excluded. Under dependent variable of CCB use, all significantly different independent variables were subjected to multivariate binary logistic regression analysis (MBLRA). Results: Lower hemoglobin, lower bilirubinemia, higher serum EPO, higher systolic blood pressure were observed in CCB users. Two groups were similar concerning age, gender, BMI, CKD etiology, CKD stage, pretibial edema prevalence, cardiothoracic index, diastolic blood pressure, corrected reticulocyte count, BUN, creatinine, eGFR, proBNP, parathormone, alkaline phosphatase, phosphorous, corrected calcemia, sCRP, relative EPO deficiency and prevalence of relative EPO deficient patients. Groups were comparable regarding comorbidities, types and usage frequencies of all antihypertensive medications other than CCBs. Higher systolic blood pressure and lower hemoglobin were significantly associated with CCB use after MBLRA. Conclusions: Hemoglobin was significantly lower in CCB users compared to non-users, among CKD patients who did not receive RRT, EPO, phosphate binders, vitamin D, iron, vitamin B12 and folic acid.Publication Metadata only PREMENOPOZAL KADINLARDA SIK GÖRÜLEN DEMİR EKSİKLİĞİ ANEMİSİNDE SORUN VİTAMİN K EKSİKLİĞİ OLABİLİR Mİ?(2018-10-10T00:00:00Z) KARATOPRAK, CUMALİ; KARAASLAN, TAHSİN; ŞEKERCİ, ABDÜSSELAM; OLGAÇ, ATİLLA; KARATOPRAK, CUMALİ; ŞEKERCİ, ABDÜSSELAMPublication Metadata only Protective effect of dexpanthenol against nephrotoxic effect of amikacin: An experimental study(2017-05-01) Dogan, ELİF ECE; ERKOC, Reha; EKINCI, Iskender; HAMDARD, Jamshid; DONER, Baris; KARATOPRAK, CUMALİ; Coban, GANİME; Ozer, Omer Faruk; Kazancioglu, RÜMEYZA; DOĞAN, ELİF ECE; KARATOPRAK, CUMALİ; ÇOBAN, GANİME; ÖZER, ÖMER FARUK; KAZANCIOĞLU, RÜMEYZABackground: Amikacin has the largest spectrum among aminoglycosides, its nephrotoxic effect limits its utilization. Our purpose in this study is to review the protective effect of dexpanthenol against the nephrotoxic effect of amikacin, accompanied with histopathological and biochemical parameters.Publication Metadata only The levels of β-thromboglobulin in female rheumatoid arthritis patients as activation criteria.(2013-05-01) ABANONU, Gul Babacan; UYAR, S; PEHLEVAN, SM; OKUROGLU, N; DEMIRTUNÇ, R; KARATOPRAK, CUMALİPublication Open Access An Iron Deficiency Anemia Case That Came with Raw Rice Consumption(2015-02-01) ÇAMLI, AHMET ADİL; KARATOPRAK, CUMALİ; ÇETİN, GÜVEN; ZORLU, MEHMET; ALAY, MURAT; ÇAMLI, AHMET ADİL; KARATOPRAK, CUMALİ; ÇETİN, GÜVEN; ZORLU, MEHMETPica is the chronic consumption of edible or nonedible materials that is thought to be caused by mental problems, pregnancy, or anemia. We wanted to report this case, which we have not seen in the literature before, of a pica patient who consumed raw rice due to iron deficiency anemia. A 26-year-old female patient was brought to the internal medicine polyclinic by her mother with complaints of consuming a bowl of raw rice (200 gr) every evening. The patient was treated with parenteral ferik hydroxide + sucrose complex (2700 mg) for 5 days. After 15 days, when she came to control her will to eat raw rice had been lost completely. As a result, the attention of doctors and family members for pica due to treatable causes, such as anemia, will prevent many probable complications.Publication Metadata only Amikasinin nefrotoksik etkisine karşı dekspantenolun koruyucu etkisi: Deneysel bir çalışma(2014-10-26) DOĞAN, ELİF ECE; EKINCI, ISKENDER; HAMDARD, JAMSHID; DONER, BARIS; CIKRIKCIOGLU, MEHMET ALI; KARATOPRAK, CUMALİ; ÇOBAN, GANİME; ÖZER, ÖMER FARUK; KAZANCIOĞLU, RÜMEYZA; DOĞAN, ELİF ECE; KARATOPRAK, CUMALİ; ÇOBAN, GANİME; ÖZER, ÖMER FARUK; KAZANCIOĞLU, RÜMEYZA