Person: ÖZTANIR, MUSTAFA NAMIK
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Publication Anesthetic approach to adult moyamoya disease: A case report Erişkin moyamoya hastasına anestetik yaklaşım: Olgu sunumu(2010-01-01T00:00:00Z) Said Aydoǧan, M.; YÜCEL, AYTAÇ; ÖZGÜL, ÜLKÜ; Öztürk, Erdoǧan; Konur, Hüseyin; Namik Öztanir, MUSTAFA NAMIK; Özcan Ersoy, M.; ÖZTANIR, MUSTAFA NAMIKMoyamoya disease is an entity, which is caused by obstruction or stenosis in the area between the internal carotid artery, and anterior and middle cerebral arteries, identified angiographically, and does not have an exactly known etiology. The most frequent symptoms of onset are hemorrhage in adults and ischemia in children. In the treatment of moyamoya disease revascularization surgery is performed in order to decrease the vascular fragility. A specialized care is required in the perioperative period since surgery is often complicated by cerebral ischemia or cerebral hemorrhage. Aim in the perioperative anesthetic management is to provide the balance between oxygen supply to and use in the brain. In this case report we aimed to discuss the anesthetic management in a 22-year-old male patient with moyamoya disease in whom a multipl burr hole surgery was performed. © Gülhane Askeri Ti{dotless}p Akademisi 2010.Publication The beneficial effects of 18 beta-glycyrrhetinic acid following oxidative and neuronal damage in brain tissue caused by global cerebral ischemia/reperfusion in a C57BL/J6 mouse model(2014-08-01T00:00:00Z) ÖZTANIR, MUSTAFA NAMIK; ÇİFTÇİ, OSMAN; Cetin, Asli; DURAK, MEHMET AKİF; Basak, Nese; Akyuva, Yener; ÖZTANIR, MUSTAFA NAMIKThis study investigated the effects of 18 beta-glycyrrhetinic acid (GA) on neuronal damage in brain tissue caused by global cerebral ischemia/reperfusion (I/R) in C57BL/J6 mice. All subjects (n = 40) were equally divided into four groups: (1) sham-operated (SH), (2) I/R, (3) GA, and (4) GA+I/R. The SH group was used as a control. In the I/R group, the bilateral carotid arteries were clipped for 15 min, and the mice were treated with the vehicle for 10 days. In the GA group, mice were given GA (100 mg/kg) for 10 days following a median incision without carotid occlusion. In the GA+I/R group, the I/R model was applied to the mice exactly as in the I/R group, and they were then treated with the same dose of GA for 10 days. Cerebral I/R significantly induced oxidative stress via an increase in lipid peroxidaitons and a decrease in elements of the antioxidant defense systems. However, GA treatment was protective against the oxidative effects of I/R by inducing significant increases in antioxidant defense systems and a significant decrease of lipid peroxidations. Additionally, cerebral I/R increased the incidence of histopathological damage and apoptosis in brain tissue, but these neurodegenerative effects were eliminated by GA treatment. Therefore, the current study demonstrated that GA treatment effectively prevents oxidative and histological damage in the brain caused by global I/R. In this context, GA may be useful for the attenuation of the negative effects of global cerebral I/R and, in the future, it may be a viable and safe alternative treatment for ischemic stroke in humans.Publication Effects of contrast material on the metabolite ratios in single-voxel MR Spectroscopy of intraaxial brain tumors(2012-08-01) Alkan, ALPAY; Burulday, Veysel; Oztanir, Namik; Dogan, Metin; ERBAY, MEHMET FATİH; Kocak, Ayhan; Aralasmak, AYŞE; ALKAN, ALPAY; ÖZTANIR, MUSTAFA NAMIK; ARALAŞMAK, AYŞEAim: The purpose of our study was to determine whether the administration of contrast material affects the results of MR Spectroscopy (MRS) in different intraaxial brain tumors.Publication Pott’s Puffy tumor and intracranial complication developing secondary to acute frontal sinusitis: A case report Akut frontal sinüzite bağlı gelişen pott’s puffy tümör ve intrakraniyal enfeksiyon: Olgu sunumu(2016-01-01T00:00:00Z) BAYINDIR, TUBA; Fırat, Çiğdem; Özerk, Ali; ÖZDEMİR, ZEYNEP; Öztanır, Namık; ÖZTANIR, MUSTAFA NAMIK© 2016, Logos Medical Publishing. All rights reserved.Pott’s puffy tumor is a complication that can be seen after frontal sinusitis and considered as a surgical emergency. Although it is rare, given the potential for significant morbidity, a high index of suspicion for Pott’s puffy tumor is required in patients presenting with fluctuant, tender, erythematous swelling of the scalp. High clinical suspicion for the diagnosis of the disease and confirmation of the diagnosis with imaging studies are necessary. In treatment it is important to combine the medical and surgical treatment modalities to avoid intracranial complications. In this case report, a male patient with a Potts puffy tumour developed after frontal sinusitis was presented.Publication Comparison of immunological, histological and oxidative effects of felbamate and levetiracetam in traumatic brain injury(2020-01-01T00:00:00Z) Bayhan, I; TURTAY, MUHAMMET GÖKHAN; ÇİFTÇİ, OSMAN; ÇETİN, AYMELEK; Basak, N.; ÖZTANIR, MUSTAFA NAMIK; OĞUZTÜRK, HAKAN; GÜRBÜZ, ŞÜKRÜ; Guven, T.; ÖZTANIR, MUSTAFA NAMIKOBJECTIVE: We aimed to compare immunological, histological and oxidative effects of antiepileptic agents; felbamate and levetiracetam on head trauma in rats.Publication Promising outcome of patients with recurrent glioblastoma after Gamma Knife-based hypofractionated radiotherapy(2024-03-01) HATİBOĞLU M. A.; Akdur K.; Sakarcan A.; SEYİTHANOĞLU M. H.; TÜRK H. M.; Sinclair G.; ÖZTANIR M. N.; HATİBOĞLU, MUSTAFA AZİZ; SEYİTHANOĞLU, MEHMET HAKAN; TÜRK, HACI MEHMET; ÖZTANIR, MUSTAFA NAMIKBackground: The role of Gamma Knife radiosurgery (GKRS) in recurrent glioblastoma remains unclear. The purpose of this study is to evaluate the effects of GKRS in a group of patients with recurrent glioblastoma, focusing on survival and safety. Methods: Patients undergoing GKRS for recurrent glioblastoma between September 2014 and April 2019 were included in this study. Relevant clinical and radiosurgical data, including GKRS-related complications, were recorded and analyzed. Overall survival (OS), local progression free survival (LPFS) and prognostic factors for outcome were thoroughly evaluated. Results: Fifty-three patients were analyzed (24 female, 29 male). The median age was 50 years (range, 19–78 years). The median GKRS treatment volume was 35.01 cm3 (range, 2.38-115.57 cm3). Twenty patients (38%) were treated with single fraction GKRS, while 33 (62%) were treated with GKRS-based hypofractionated stereotactic radiotherapy (HSRT). The median prescription dose for single fraction GKRS, 3-fractions HSRT and 5-fractions HSRT were 16 Gy (range, 10−20 Gy), 27 Gy (range, 18−33 Gy) and 25 Gy (range, 25−30 Gy), respectively. The median LPFS and OS times were 8.1 months and 11.4 months after GKRS, respectively. HSRT and Bevacizumab were associated with improved LPFS, while HSRT alone was associated with longer OS. Conclusion: Our findings suggested that HRST would likely improve LPFS and OS in definite settings; the addition of Bevacizumab to GKRS was associated with increased rates of local control. No major complications were reported. Further prospective studies are warranted to confirm our findings.Publication Spontaneous resolution of fetal dural sinus thrombosis following term delivery of a live infant(2012-11-01T00:00:00Z) Simsek, Y.; Oztanir, N.; SIĞIRCI, AHMET; ÇELİK, ELİF; YILMAZ, ERCAN; Celik, O.; Onal, C.; ÖZTANIR, MUSTAFA NAMIKPublication A SURPRISE RESPONSE TO TRAMETINIB AND DABRAFENIB COMBINATION IN A HIGH GRADE GLIOMA(2022-11-01) ÇAKIR F. B.; ÇELİK ATEŞ D.; ÇOBAN G.; ALKAN A.; TEKÇE E.; ÖZTANIR M. N.; ÇAKIR, FATMA BETÜL; ÇOBAN, GANİME; ALKAN, ALPAY; TEKÇE, ERTUĞRUL; ÖZTANIR, MUSTAFA NAMIKPublication Brain Perfusion MRI Findings in Patients with Behcet-s Disease(2012-01-01T00:00:00Z) Alkan, ALPAY; GOKTAN, Asli; Karincaoglu, Yelda; KAMIŞLI, SUAT; Dogan, Metin; Oztanir, Namik; Turan, Nergiz; KOCAKOC, Ercan; ALKAN, ALPAY; ÖZTANIR, MUSTAFA NAMIKObjective. To search brain perfusion MRI (pMRI) changes in Behcet-s disease (BD) with or without neurological involvement. Materials and Method. The pMRI were performed in 34 patients with BD and 16 healthy controls. Based on neurologic examination and post-contrast MRI, 12 patients were classified as Neuro-Behcet (group 1, NBD) and 22 patients as BD without neurological involvement (group 2). Mean transit time (MTT), time to peak (TTP), relative cerebral blood volume (rCBV), and relative cerebral blood flow (rCBF) were obtained and compared to those of healthy control group (group 3). Results. There was a significant difference in the MTT and rCBF within the pons and parietal cortex in groups 1 and 2. rCBV increased in cerebral pedicle in group 1 compared with groups 2 and 3. In the temporal lobe white matter, prolonged MTT and decreased rCBF were found in groups 1 and 2. In the corpus striatum, internal capsule, and periventricular white matter, rCBF increased in group 1 compared with group 3 and decreased in groups 1 and 2. Conclusion. Brain pMRI is a very sensitive method to detect brain involvement in patients with BD and aids the clinical diagnosis of NBD, especially in patients with negative MRI findings.Publication Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury(2019-03-01T00:00:00Z) KAMIŞLI, SUAT; Basaran, Cenk; BATÇIOĞLU, KADİR; ÖZTANIR, MUSTAFA NAMIK; GÜL, MEHMET; SATILMIŞ, BASRİ; UYUMLU, AYŞE BURÇİN; KAYHAN, BAŞAK; Genc, Metin; ÖZTANIR, MUSTAFA NAMIKIntroduction: RS100642, a mexiletine analogue, is a novel sodium channel blocker with neuroprotective and antioxidant activities. The protectivity of RS100642, which has been shown against focal cerebral ischemia, was investigated in global cerebral ischemia in this study.
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