Person: MEMMİ, NAİM
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Publication Open Access Diffusion MRI on lymph node staging of gastric adenocarcinoma(2015-06-01) HASBAHCECI, Mustafa; Akcakaya, ADEM; Memmi, NAİM; TURKMEN, Ihsan; Cipe, Gokhan; Yildiz, PELİN; Arici, DİLEK SEMA; MUSLUMANOGLU, Mahmut; AKÇAKAYA, ADEM; MEMMİ, NAİM; YILDIZ, PELİN; ARICI, DILEK SEMAObjective: The purpose of this study was to evaluate the accuracy of diffusion weighted magnetic resonance imaging (MRI) in preoperative assessment of metastatic lymph nodes of gastric cancer. Methods: A total of 23 gastric cancer patients with a mean age of 59.4±10.9 years were analyzed. Lymph nodes were grouped as perigastric lesser curvature (Group Ia), perigastric greater curvature (Group Ib), D1+/D2 lymph nodes (Group II). Identification of histologically metastatic lymph nodes by diffusion weighted MRI was regarded as the main outcome. Results: A total of 1,056 lymph nodes including 180 histologically proven metastatic lymph nodes were dissected. Although diffusion weighted MRI could identify the metastatic lymph nodes in 18 out of 23 patients (77.8%), only 69 of total 1,056 nodes (6.53%), either metastatic or non-metastatic, could be detected. There was no correlation between histopathology and diffusion weighted MRI with regard to lymph node groups (P>0.05 for all). Overall accuracy was calculated as 69.56, 65.21 and 52.17 for Groups II, Ib and Ia lymph nodes, respectively. Apparent diffusion coefficient (ADC) values could not be helpful to differentiate metastatic lymph nodes (P=0.673). Conclusions: Diffusion weighted MRI has low accuracy to detect or to differentiate metastatic and non-metastatic lymph nodes based on their ADC values in gastric cancer.Publication Open Access Remission of ulcerated necrobiosis lipoidica diabeticorum after bariatric surgery.(2013-01-01) BOZKURT, SÜLEYMAN; COSKUN, HALİL; Kadioglu, HÜSEYİN; MEMMI, NAİM; CIPE, G; ERSOY, YELİZ EMİNE; LEBE, B; MUSLUMANOGLU, M; BOZKURT, SÜLEYMAN; COŞKUN, HALIL; KADIOĞLU, HÜSEYİN; MEMMİ, NAİM; ERSOY, YELIZ EMINEA 32-year-old woman with type 2 diabetes mellitus suffering from morbid obesity with BMI 45,14 kg/m2 was operated on. Not only the type 2DM but also one of its complication known as necrobiosis lipoidica diabeticorum remitted postoperatively. Obesity should no longer be regarded simply as a cosmetic problem affecting certain individuals but an epidemic that threatens global well-being. It causes or exacerbates many health problems, and in particular, it is associated with the type 2 diabetes. Necrobiosis lipoidica is a granulomatous skin disease of unknown etiology, associated mainly with diabetes mellitus. We presented in this paper a morbid obese case of necrobiosis lipoidica diabeticorum with dramatic good response to bariatric surgery.Publication Open Access Unpredictable behavior of breast phyllodes tumors(2014-09-01) Akcakaya, ADEM; KOC, B.; EROZGEN, F.; Memmi, NAİM; HOT, S.; YILDIZ, M. K.; GUCIN, ZÜHAL; ADAS, G.; Kemik, Özgür; AKÇAKAYA, ADEM; MEMMİ, NAİM; GÜCİN, ZÜHAL– OBJECTIVE: Phyllodes Tumor is a rare fibroepithelial breast tumor with variable malignant potential. These tumors that currently accepted nomenclature are benign, borderline and malignant according to the World Health Organization. It tends to behave in a benign way but it may undergo a malignant transformation. The purpose of this study was to present our Case load of phyllodes tumor, and evaluate the management and follow-up the behavior of these tumors. PATIENTS AND METHODS: 36 patients with phyllodes tumor were treated in Bezmialem Vakif University and Okmeydani Training and Research Hospitals analyzed retrospectively. Demographics, presenting symptoms, history, local examination, preoperative clinical diagnosis, treatment, postoperative histopatology, followup period were evaluated retrospectively and studied. RESULTS: A total of 36 patients treated for phyllodes tumor were analyzed. Mean age of the patients was 38 (14-79) and all were females. The presentation of the patients was breast lump in all cases, either as a primary or recurrent lump presentation. The right and left breast were affected 58% and 42% respectively. 34 of these 36 cases are briefly mentioned in this paper but the two cases, one with sarcomatous malignant transformation and the other with fatal metastatic phyllodes tumor in an adolescent female are discussed in detail. The mean duration of the symptomatic mass was 9.8 ± 7.3 months (range 0.5 to 24). CONCLUSIONS: Phyllodes tumor is a type of tumor that may be benign or malignant. The type with malignant features may be fatal. The tumors diagnosed as benign may transform and become malignant because of unknown reasons and may be an aggressive tumor.Publication Open Access Routine use of positron-emission tomography/computed tomography for staging of primary colorectal cancer: Does it affect clinical management?(2013-02-01T00:00:00Z) Cipe, Gokhan; Ergul, Nurhan; Hasbahceci, Mustafa; Firat, Deniz; BOZKURT, SÜLEYMAN; MEMMİ, NAİM; Karatepe, Oguzhan; Muslumanoglu, Mahmut; BOZKURT, SÜLEYMAN; MEMMİ, NAİMBackground: The use of positron emission tomography-computed tomography (PET/CT) for the preoperative staging of patients with colon and rectal cancer has increased steadily over the last decade. The aim of this study was to evaluate the effect of PET/CT on the preoperative staging and clinical management of patients with colorectal cancer.Publication Open Access Intersphincteric resection and coloanal anastomosis in treatment of distal rectal cancer.(2012-01-01) CIPE, G; MUSLUMANOGLU, M; YARDıMCı, ERKAN; MEMMI, NAİM; Aysan, E; YARDIMCI, ERKAN; MEMMİ, NAİM; AYŞAN, MUSTAFA ERHANIn the treatment of distal rectal cancer, abdominoperineal resection is traditionally performed. However, the recognition of shorter safe distal resection line, intersphincteric resection technique has given a chance of sphincter-saving surgery for patients with distal rectal cancer during last two decades and still is being performed as an alternative choice of abdominoperineal resection. The first aim of this study is to assess the morbidity, mortality, oncological, and functional outcomes of intersphincteric resection. The second aim is to compare outcomes of patients who underwent intersphincteric resection with the outcomes of patients who underwent abdominoperineal resection.Publication Open Access Cinical Significance of Androgen Receptor, CK-5/6, KI-67 and Molecular Subtypes in Breast Cancer.(2014-10-01) KAYAHAN, M; İDIZ, UO; Gucin, ZÜHAL; EROZGEN, F; MEMMI, NAİM; MUSLUMANOGLU, M; GÜCİN, ZÜHAL; MEMMİ, NAİMObjective: To detect the relationship between molecular subtypes of breast cancer with expressions of androgen receptor, cytokeratin 5/6 (CK5/6)and Ki-67. Materials and methods: Expressions of androgen receptor, CK-5/6 and Ki-67 were determined by immunohistochemistry in paraffin-embedded sections obtained from 86 invasive breast cancer cases of stages I/IIa/IIb in 4 molecular subtypes. Patients treated for recurrent disease and locally advanced disease were excluded. Results: Forty one luminal A cases, ie. positive estrogen receptor(ER) and/or progesteron receptor (PR) with negative epidermal growth factor receptor (HER2), 14 luminal B, ie. positive ER and/or PR and positive HER2, 14 HER2-enriched (HER2+), ie. negative ER and PR with positive HER2, and 17 triple negative (negative ER and PR and HER2) invasive breast cancers were included. Mean follow-up was 17.46±11.70 mo. Androgen receptor-negativity and CK5/6-positivity were significantly more common in HER2+ and triple negative groups. Ki-67 and histological grade were higher in HER2+ group, significantly. Two deaths were triple negative (P=0.04). Androgen receptor-negativity, CK5/6 and Ki-67 status did not affect survival or systemic metastases, significantly. All groups had local recurrences. Local recurrence was significantly associated with androgen receptor-negativity in luminal A and high Ki-67 value in HER2+ groups. Systemic metastases were significantly more common in triple negative and HER2+ groups. Conclusion: Molecular subtypes of breast cancer are prognostic and predictive. Androgen receptor is expressed more commonly in luminal subtypes with better prognosis and androgen receptor negativity is associated with development of local recurrence in luminal A cancers.Publication Open Access Ischemia Modified Albumin Can Predict Necrosis at Incarcerated Hernias(2013-01-01) Kadioglu, HÜSEYİN; Omur, Dilek; Bozkurt, SÜLEYMAN; FERLENGEZ, Ekrem; Memmi, NAİM; Ersoy, YELİZ EMİNE; CIPE, Gokhan; Muslumanoglu, Mahmut; KADIOĞLU, HÜSEYİN; BOZKURT, SÜLEYMAN; MEMMİ, NAİM; ERSOY, YELIZ EMINEPurpose. To evaluate the predictive effect of IMA in incarcerated hernias. Methods. Three groups (𝑛=7) of rats were operated. Group I aimed to mimic incarceration, group II aimed the strangulation, and group III was the sham group. IMA and LDH measurements were made. Results. IMA levels were significantly higher in strangulation mimicking group and IMA levels were normal at postoperative 6th hour in incarceration mimicking group. LDH levels were significantly higher in both incarceration and strangulation mimicking groups. Conclusion. IMA seems to be an effective marker in incarcerated hernias to predict necrosis. But we need further studies to generalise this hypothesis.Publication Metadata only Role of obesity and abdominal shape morphometric features to predict postoperative complications and quality of lymph node dissection of gastrectomy for gastric cancer(2017-01-01) HASBAHCECI, MUSTAFA; Mehdi, Elnur; Malya, FATMA ÜMİT; Kunduz, ENVER; Memmi, NAİM; Yigman, SAMET; Akcakaya, ADEM; MALYA, FATMA ÜMİT; KUNDUZ, ENVER; MEMMİ, NAİM; YIĞMAN, SAMET; AKÇAKAYA, ADEMObesity and abdominal shape morphometric features have been thought to be independent risk factors for surgical outcomes after gastrectomy.