Person: MEYDAN, SEDAT
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Publication Effects of lemon essential oil aroma on the learning behaviors of rats.(2010-10-01T00:00:00Z) OGETURK, M; KOSE, E; SARSıLMAZ, M; AKPINAR, B; KUS, I; Meydan, SEDAT; MEYDAN, SEDATPublication Salt and Nitric Oxide Synthase Inhibition-Induced Hypertension: Kidney Dysfunction and Brain Anti-Oxidant Capacity(2010-01-01T00:00:00Z) Oktar, Suleyman; Ilhan, Selcuk; Meydan, SEDAT; Aydin, Mehmet; Yonden, Zafer; Gokce, Ahmet; MEYDAN, SEDATThe specific aim of this study was to examine the effects of salt-loading on kidney function and brain antioxidant capacity. Wistar rats were divided into four groups: Control rats were given normal drinking water and no drug treatment for 2 weeks. LNNA group: rats were given normal drinking water and the nitric oxide (NO) inhibitor NG-nitro-L-arginine (L-NNA), 3 mg/kg/day. LNNA + Salt group: rats were given drinking water containing salt 2% and 3 mg/kg L-NNA. Salt group: rats were given drinking water containing salt 2% and no drug treatment. Basal blood pressure and the levels of serum BUN, creatinine, uric acid, cortisol, electrolyte, serum antioxidant capacity, and oxidative stress were measured. NO, superoxide dismutase (SOD), and catalase (CAT) levels were measured in the hypothalamus, brainstem, and cerebellum. Salt overload increased the blood pressure of the LNNA + Salt group. Salt-loading enhanced BUN, creatinine, sodium retention. High salt produced an increase in uric acid levels and a decrease in cortisol levels in serum. Additionally, the oxidative stress index in serum increased in the LNNA + Salt group. Salt-loading enhanced brain NO levels, but not SOD and CAT activity. L-NNA increased brain SOD activity, but not CAT and NO levels. In conclusion, salt-loading causes hypertension, kidney dysfunction, and enhances oxidative stress in salt-sensitive rats.Publication Protective effects of caffeic acid phenethyl ester and thymoquinone on toluene induced liver toxicity.(2019-05-01) Esrefoglu, MUKADDES; Bayındır, NİHAN; KURBETLI, N; Selek, S; Akbas, Tosunoglu; Meydan, SEDAT; OZTURK, OSMAN; Bulut, HURİ; Meral, I; MEYDAN, SEDAT; EŞREFOĞLU, MUKADDES; SELEK, ŞAHABETTİN; ÖZTÜRK, OSMAN; BAYINDIR, NİHAN; BULUT, HURI; MERAL, İSMAİLPublication Effects of ceftriaxone on ischemia/reperfusion injury in rat brain(2013-03-01T00:00:00Z) Altas, M.; Meydan, SEDAT; Aras, M.; Yilmaz, N.; Ulutas, K. T.; Okuyan, H. M.; Nacar, A.; MEYDAN, SEDATThe aim of this study was to investigate the effect of ceftriaxone treatment against short-term global brain ischemia/reperfusion (I/R) injury in rats. The study was carried out on 30 Wistar-albino rats that were divided into three groups: control group (n = 10), I/R group (n = 10) and I/R-ceftriaxone group (n = 10). Malondialdehyde (MDA) levels were significantly increased in the I/R group in comparison with the control group (p < 0.001). MDA was significantly lower in the I/R-ceftriaxone group than in the I/R group (p < 0.05). Superoxide dismutase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the control group. Glutathione peroxidase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the I/R group and the control. Histopathologically, ceftriaxone provided morphological improvement compared with the I/R group. We concluded that ceftriaxone has neuron-protective effects due to its antioxidant properties as shown by a decrease in MDA overproduction and histological improvement in brain tissue. (C) 2012 Elsevier Ltd. All rights reserved.Publication EVALUATION OF THE FACIAL ARTERY IN TURKISH POPULATION WITH 3D CT ANGIOGRAPHY(2024-05-02) Taşçı A. K.; Meydan S.; Arifoğlu Y.; Balsak S.; Atasoy B.; Pasin Ö.; MEYDAN, SEDAT; ARİFOĞLU, YASİN; ATASOY, BAHAR; PASİN, ÖZGETÜRK TOPLUMUNDA A. FACIALIS’İN ÜÇ BOYUTLU BT ANJİYOGRAFİ İLEDEĞERLENDİRİLMESİÖZETGiriş: A. facialis, çene ve yüz bölgesinin arteriyel beslenmesinden sorumlu ana damardır. Bu arterin varyatif seyrinin bilinmesi, yüz bölgesine yapılan intraarteriyel dolgu enjeksiyonu gibi klinik uygulamalar sonrası komplikasyonların önlenmesi açısından fazlaca önemlidir. Bu çalışmanın amacı, Türk toplumunda 3D BT görüntülerinde a. facialis’in anatomisini incelemek ve yüz bölgesine yapılacak işlemlerde oluşabilecek komplikasyonlara karşı elde edilen veriler ışığında klinisyenlere kılavuz oluşturmaktır.Yöntem: Çalışmaya 18 ile 65 yaş arası 72 erkek, 38 kadın olmak üzere 110 birey dahil edildi. Çalışma olguları Fuji PACS’tan Syngo.via (software version syngo.via VB30A_HF06, Siemens, Germany) iş istasyonuna yüklendi. İncelenen BT Anjiyografi görüntüleri üzerinden a. facialis’e ait çeşitli parametreler değerlendirildi.Bulgular: A. facialis tipleri sağda 13 solda 5 adet tip 1, sağda 92 solda 87 adet tip 3, sağda 1 solda 1 adet tip 4 ve sağ tarafta 2 adet tip 5 tespit edildi. Tüm tiplerde sağ ve sol taraflar arasında istatistiksel olarak anlamlı fark bulundu (p<0,001). A. facialis’in ala nasi inferior’una, canthus medialis’e, orbita orta noktasına olan uzaklıkları ve arterin mandibuladan çıkış noktası ile comissura labiorum arasındaki mesafe ölçümlerinde sağ ve sol taraflarda anlamlı farklar gözlendi (p=0,042, p=0,010, p=0,005, p<0,001). Bununla beraber a. facialis’in sulcus nasolabialis’e göre seyri incelendi. Buna göre sağda 82 solda 77 medialde seyreden, sağda 13 solda 6 lateralde seyreden, sağda 7 solda 6 medialden laterale doğru, sağda 7 solda 8 lateralden mediale doğru geçen tip görüldü. Tüm tiplerde sağ ve sol taraflar arasında ve sağ-sol simetrileri arasında anlamlı farklar bulundu (p<0,001). Derinlik ölçümlerinde sulcus a. facialis’te deri-arter arası mesafe ve ala nasi’nin inferior’u seviyesinde kemik-arter arası mesafe sağ ve sol taraflar arasındaki fark istatistiksel olarak anlamlıydı (p=0,001, p=0,021).Sonuç: Bu çalışmanın sonucunda a. facialis varyasyonlarının ve sıklıkla uygulama yapılan bölgelerdeki derinliğinin bilinmesi klinisyenlere işlem sırasında güvenlik sağlayacağı düşünülmektedir. Ek olarak derinlik ölçümlerinin radyolojik yöntemlerle yapılabilmesi kadavra çalışmaları için gereken sürenin minimum düzeye indirgenmesi açısından da değerlidir.Anahtar kelimeler: A. facialis, A. facialis tipleri, BT Anjiyografi, Sulcus nasolabialis, DerinlikPublication Assessment of Auditory Pathways Using Diffusion Tensor Imaging in Patients with Neurofibromatosis Type 1(2018-04-01) MEYDAN, SEDAT; Aydin, Sinem; OTCU, HAFİZE; KİTİŞ, SERKAN; ALKAN, ALPAY; MEYDAN, SEDAT; KİTİŞ, SERKAN; ALKAN, ALPAYThe aim of our study was to determine whether the diffusion properties of the auditory pathways alter between patients with Neurofibromatosis type 1 (NF1) and the healthy subjects. DTI can well demonstrate FA and ADC changes in auditory tracts and it may be a guide to identify the candidates for hearing loss among NF1 children.Publication Could the PON1 phenotype play a key role in insulin resistance?(2022-06-01T00:00:00Z) Sarikaya, Ufuk; Meydan, Sedat; Selek, Şahabettin; Sarikaya, Alime; Demirel, Metin; Gül, Ayşe Zehra; Yildiz, Tuğçe; SARIKAYA, UFUK; MEYDAN, SEDAT; SELEK, ŞAHABETTİN; DEMİREL, METİN; GÜL, AYŞE ZEHRA; YILDIZ, TUĞÇEAim/objectivesRecent studies have shown that Paraoxonase (PON1) enzyme plays a possible role in insulin synthesis by stimulating insulin release from β-cells of the pancreas as well as its anti-atherosclerotic property. In our study, we revealed the relationship between phenotypes of the PON1 enzyme and insulin resistance (IR) and impaired fasting glucose (IFG).Materials and methodsA cohort of 71 IR, 63 IFG, and 68 healthy individuals was examined in this study. The phenotypic distribution was demonstrated by studying PON1 enzyme’s Paraoxonase (POase) and Arylesterase (AREase) activity with automated measurement kits.ResultsBy measuring the ratio of POase activity to AREase activity, 3 different phenotypes (QQ (Risky or Bad Phenotype), QR (Notre Phenotype), and RR (Good Phenotype)) were discovered. The results showed that IR and IFG individuals had riskier phenotypes compared to the control group. In addition, individuals with bad phenotypes were found to be 1.85 and 2.16 times more likely to get IR and IFG, respectively. Both groups were found to be four times more likely to be affected by the bad phenotype (odds ratio: 3.69 and 4.47 respectively).ConclusionIn this present study, the relationship between PON1 enzyme phenotypes and IR was evaluated for the first time in this field. Decreased PON1 activity and poor phenotype may also increase the development of hyperglycemia or diabetes mellitus (DM) due to IR and IFG. It may also predispose to diseases such as atherosclerosis. Therefore, we think that further investigations to explain the possible mechanisms underlying the relationship between PON1 phenotypes, IR and IFG will be useful in the early diagnosis and prevention ofprediabetes.Publication Protective effects of omega-3 essential fatty acids against formaldehyde-induced cerebellar damage in rats(2011-07-01T00:00:00Z) Zararsiz, Ismail; Meydan, SEDAT; Sarsilmaz, Mustafa; Songur, Ahmet; Ozen, Oguz Aslan; Sogut, Sadik; MEYDAN, SEDATThis study aimed to investigate changes in the cerebellum of formaldehyde-exposed rats and the effects of omega-3 fatty acids on these changes. The study involved 21 male Wistar-Albino rats which were divided into three groups. The rats in Group I comprised the control group. The rats in Group II were injected with intraperitoneal 10% formaldehyde every other day. The rats in Group III received omega-3 fatty acids daily while exposed to formaldehyde. At the end of the 14-day experimental period, all rats were killed by decapitation and the cerebellum removed. The activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), xanthine oxidase (XO), and malondialdehyde (MDA) levels were determined in cerebellum specimens by using spectrophotometric methods. In our study, levels of SOD and CAT were significantly decreased, and GSH-Px, XO, MDA levels were significantly increased in rats treated with formaldehyde compared with those of the controls. Whereas, it was seen that there was an increase in SOD and CAT enzyme activities and decrease in MDA, XO, and GSH-Px levels in rats administered to omega-3 fatty acids with exposure of formaldehyde. It was determined that exposure of formaldehyde increased free radicals in cerebellum of rats and this increase was prevented by administration of omega-3 fatty acids.Publication Possible effects of caffeic acid phenethyl ester and thymoquinone against toluene brain injury(2019-08-31T00:00:00Z) MEYDAN, SEDAT; EŞREFOĞLU, MUKADDES; SELEK, ŞAHBETTİN; AKBAŞ TOSUNOĞLU, ESRA; öztürk, özlem; kurbetli, nuriye; BAYINDIR, NİHAN; BULUT, HURİ; MERAL, İSMAİL; SÜSGÜN, SEDA; AKBAŞ, FAHRİ; MEYDAN, SEDAT; EŞREFOĞLU, MUKADDES; SELEK, ŞAHABETTİN; MERAL, İSMAİL; SÜSGÜN, SEDA; AKBAŞ, FAHRİPublication The protective effects of omega-3 fatty acid against toluene-induced neurotoxicity in prefrontal cortex of rats.(2012-11-01T00:00:00Z) Meydan, SEDAT; ALTAS, M; NACAR, A; OZTÜRK, OSMAN; TAS, U; ZARARSıZ, I; SARSıLMAZ, M; MEYDAN, SEDAT; ÖZTÜRK, OSMAN
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