Person: BÜYÜKAYDIN, BANU
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Publication Open Access An unusual cause of peritonitis in peritoneal dialysis patients: Pantoea agglomerans(2014-07-01) Buyukaydin, BANU; Kazancioglu, RÜMEYZA; IRAZ, Meryem; ALAY, Murat; ERKOC, Reha; KAZANCIOĞLU, RÜMEYZA; BÜYÜKAYDIN, BANUPeritonitis is a serious infection and early diagnosis and treatment is mandatory. A variety of microorganisms are identified in these cases and during recent years a new one was included, Pantoea agglomerans. In this case report, a female patient on continuous ambulatory peritoneal dialysis therapy with a peritonitis episode caused by this organism is described. The source of infection was thought to be due to contact of catheter with non-sterile surfaces. In microbiologic culture, this organism was identified and the patient successfully treated with a three week course of gentamicin therapy. The number of reported cases with this organism has increased in last years and various infection localizations and clinical progress patterns have been identified. In peritoneal dialysis patients presenting with peritonitis, this organism must be kept in mind.Publication Open Access Relationship between diabetic polyneuropathy, serum visfatin, and oxidative stress biomarkers(2020-07-01T00:00:00Z) GÜLER, Eray Metin; BÜYÜKAYDIN, BANU; Karaaslan, Tahsin; OLGAÇ, ATİLLA; ZORLU, MEHMET; KISKAÇ, MUHARREM; KOÇYİĞİT, ABDÜRRAHİM; BÜYÜKAYDIN, BANU; GÜLER, ERAY METİN; OLGAÇ, ATİLLA; ZORLU, MEHMET; KISKAÇ, MUHARREM; KOÇYİĞİT, ABDÜRRAHİMBackground: Diabetic polyneuropathy is a very common complication of diabetes. Numerous studies are available in terms of pathogenesis. But examination methods with low reliability are still not standardized and generally time consuming. High-sensitive, easy-to-access methods are expected. Biochemical markers are one of the subjects of research. We aimed to discover a potential biomarker that can be used for this purpose in patients with diabetes who have not yet developed symptoms of neuropathy. Aim: To determine the place and availability of visfatin and thiol-disulfide homeostasis in this disorder. Methods: A total of 392 patients with type 2 diabetes mellitus were included in the study. The polyneuropathy clinical signs were evaluated with the Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire and examination. The biochemical parameters, oxidative stress markers, visfatin, and thiol-disulfide homeostasis were analyzed and correlated with each other and clinical signs. Results: Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire with examination scores were correlated with each other and diabetes duration (P < 0.005). Neuropathy related symptoms were present in 20.7% of the patients, but neuropathy related findings were observed in 43.9% of the patients. Serum glucose, glycated hemoglobin, and visfatin were positively correlated with each other. Also, these parameters were positively correlated with the total oxidative stress index. Total and native thiol was positively correlated with total antioxidant status and negatively with oxidant status. Inversely thiol-disulfide positively correlated with higher glucose and oxidant status and negatively with total antioxidant status (P < 0.005). There was no correlation between visfatin and thiol-disulphide (P = 0.092, r = 0.086). However, a significant negative correlation was observed between visfatin and total with native thiol (P < 0.005, r = -0.338), (P < 0.005, r = -0.448). Conclusion: Diagnosis of neuropathy is one of the issues studied in patients with diabetes. Visfatin and thiol-disulfide balance were analyzed for the first time in this study with inspiring results.Publication Open Access Markers predicting critical illness and mortality in COVID-19 patients: A multi-centre retrospective study(2021-01-01T00:00:00Z) Büyükaydın, Banu; Karaaslan, Tahsin; Karatoprak, Cumali; Karaaslan, Esra; Sasak Kuzgun, Gulsah; Gündüz, Mehmet; Şekerci, Abdusselam; Alişir Ecder, Sabahat; KARATOPRAK, CUMALİ; ŞEKERCİ, ABDÜSSELAM; BÜYÜKAYDIN, BANUAim: In this study, we aimed to investigate early predictors of critical illness and mortality in patients with coronavirus disease 2019 (COVID-19) based onclinical, biochemical, radiological, and epidemiological findings.Materials and Methods: This multi-center, retrospective study was conducted in three centers and included a total of 206 confirmed COVID-19 cases usingreverse transcription-polymerase chain reaction (RT-PCR). Data of survivors and non-survivors were compared, and predictors of mortality were examined.Results: Among the patients, 103 (50%) were males with a mean age of 52.8±16.7 years; 88.3% of the patients were discharged in a healthy condition, while11.7% died. The mean age was significantly higher in non-survivors. Dyspnea occurred in 32.5% of patients, and a significant correlation was found betweendyspnea and mortality (p<0.001). Thoracic computed tomography (CT) findings were positive in 88.8% of patients. The most frequent imaging findings wereground-glass opacities in 86.4% and consolidation in 33% of patients. The mortality rate was significantly higher in patients with comorbidities (p<0.001).There was also a significant correlation between lymphocytopenia and mortality (p<0.001). A positive correlation was found between mortality risk andplatelet-to-lymphocyte, neutrophil-to-lymphocyte, and red cell distribution width indices. The mortality risk was significantly higher in patients with acutekidney injury (10.7%) (p<0.001).Discussion: These results suggest that advanced age, coexisting diabetes, hypertension, heart failure, chronic kidney disease, or acute kidney injury are associatedwith an increased mortality risk. The presence of dyspnoea or consolidation on thoracic CT can predict an increased mortality risk in COVID-19 patients.Publication Open Access Frequency and determinants of erectile dysfunction in Turkish diabetic men(2015-03-01) Buyukaydin, BANU; KISKAC, MUHARREM; ZORLU, MEHMET; CAKIRCA, MUSTAFA; KARATOPRAK, CUMALİ; YAVUZ, Erdinc; KISKAÇ, MUHARREM; ZORLU, MEHMET; ÇAKIRCA, MUSTAFA; BÜYÜKAYDIN, BANU; KARATOPRAK, CUMALİBackground: Erectile dysfunction (ED) or impotence is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis during sexual performance. ED is observed more frequently and manifests earlier in diabetic patients compared to the normal population. Material and Methods: One hundred and seventeen consecutive male type 2 diabetes patients seen in our Diabetes Outpatient Clinic were included in our study and these patients were evaluated in terms of the presence and duration of ED, treatment and response to treatment of ED, duration of diabetes mellitus, HbA1c levels, and the presence of microalbuminuria, estimated from 24‑hour urine collections. Results: The patients included in our study were divided into three groups: Patients with no ED, mild‑to‑moderate ED, and severe ED. Twenty‑nine patients (24.8%) fell in the no ED group, 28 (23.9%) in the mild‑to‑moderate ED group, and 60 (51.3%) in the severe ED group. There were statistically significant differences between these three groups in terms of age (P = 0.015) and duration of diabetes mellitus (P = 0.03). The groups were similar in terms of microalbuminuria measured from 24‑hour urine collections and HbA1c levels (P = 0.328 and P = 0.905, respectively). Twenty‑three of the 88 patients with ED (26.1%) were on ED treatment and 43.5% of these patients reported benefit from the therapy. Conclusion: Age and duration of diabetes were the main determinants of the presence and severity of ED in male Turkish type 2 diabetic patients. The HbA1c levels were higher in patients with ED, but the differences in levels between the groups did not reach statistical significance.Publication Metadata only The changes of oxidative stress markers and vitamin E in patients with diabetes using SGLT2 inhibitors(2023-01-01) Buyukaydin B.; ÖZER Ö. F.; ÖZDER A.; YILDIZ C.; BÜYÜKAYDIN, BANU; ÖZER, ÖMER FARUK; ÖZDER, ACLAN; YILDIZ, CANERObjectives: This study aimed to research the diversities of vitamin E and oxidative stress parameters related to sodium-glucose transport protein 2 (SGLT2) inhibitor use by type 2 diabetes mellitus (T2DM) patients. Methods: This observational clinical study collected data from 67 T2DM patients (55.7±9.3 years, 46% female). Vitamin E, total oxidant status (TOS), total antioxidant status (TAS), total thiol, native thiol, myeloperoxidase, and catalase levels were evaluated. The TOS/TAS ratio was calculated as the oxidative stress index. Correlations of the parameters to each other and differences based on SGLT2 inhibitor use were recorded. Results: The mean hemoglobin A1c was 7.1 (5.5–13.1). SGLT2 inhibitors (all combinations) were used by 25 patients (37.3%). The mean level of vitamin E was 6 (3.6–9.8) mg/L. There was a positive correlation between vitamin E and low-density lipoprotein cholesterol (p<0.001). While there was no significant correlation between vitamin E and all included oxidative stress parameters, the level of vitamin E was statistically lower in patients using pioglitazone (p=0.036) and statins (p<0.001). In patients using SGLT2 inhibitors, fasting glucose, triglycerides, alanine aminotransferase, and the spot urine protein/creatinine ratio were significantly lower, and the mean TAS was higher (p<0.05). Conclusion: While no differences were observed in vitamin E and other oxidative parameters related to SGLT2 inhibitor use, the increase in TAS provides motivation for further research investigating the antioxidant properties of these inhibitors.