Person: KILIÇ, ÖZGE
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Publication Metadata only Presentation and outcomes of attention deficit and hyperactivity disorder in females and males(2021-04-01T00:00:00Z) KILIÇ, ÖZGE; Young, S.; KILIÇ, ÖZGEPublication Metadata only How to overcome barriers to publication in low- and middle-income countries: Recommendations from early career psychiatrists and researchers from around the world(2021-12-01T00:00:00Z) El Halabi, Sarah; Abbas, Zargham; Adesokun, Fisayo; Adiukwu, Frances; Ashrafi, Agah; de Filippis, Renato; Handuleh, Jibril; Jaguga, Florence; Karaliuniene, Ruta; KILIÇ, ÖZGE; Nagendrappa, Sachin; Ojeahere, Margaret; Ogunnubi, Oluseun Peter; Ori, Dorottya; Orsolini, Laura; Pereira-Sanchez, Victor; Pinto da Costa, Mariana; Ransing, Ramdas; Shoib, Sheikh; Ullah, Irfan; Vadivel, Ramya; Vahdani, Bita; Ramalho, Rodrigo; KILIÇ, ÖZGEThere is an increasing movement toward international collaboration and global discussion in mental health. If provided with the right opportunities, early career psychiatrists (ECPs) and researchers in mental health can contribute meaningfully to this discussion. However, they often experience multiple barriers when attempting to add their voices via academic publications. We represent a diverse group of ECPs and researchers from all six World Health Organization regions. In this piece, we discuss these barriers, grounded in our first-hand experiences, and put forth a series of recommendations. The most potentially beneficial and immediate way forward is ensuring a much-needed mentorship and support, particularly for low- and middle-income countries. In this regard, international organizations, especially those with a particular focus on education, such as the Section on Education in Psychiatry of the World Psychiatric Association, can play a pivotal role.Publication Open Access COVID-19 infection, vaccine status, and avoidance behaviors in adults with attention deficit and hyperactivity disorder: A cross-sectional study(2022-08-01) KILIÇ Ö.; BOYLU M. E.; Karakaya-Erdur S.; Suma-Berberoglu M.; Gudjonsson G.; Young S.; Deveci E.; KIRPINAR İ.; KILIÇ, ÖZGE; BOYLU, MUHAMMED EMİN; DEVECİ, ERDEM; KIRPINAR, İSMETObjective: We aim to examine infection risk and vaccine status of COVID-19 in attention deficit and hyperactivity disorder and evaluate the impact of demographic, clinical, and COVID-19-related factors on the infection status and behavioral avoidance of COVID-19. Methods: This cross-sectional study assessed adults with attention deficit and hyperactivity disorder recruited from an outpatient psychiatry clinic. Patients and healthy controls completed a survey on sociodemographic data, COVID-19 infection status, and vaccine status. COVID-19 Disease Perception Scale, COVID-19 Avoidance Attitudes Scale, Attitudes toward COVID-19 Vaccine Scale, Adult Attention Deficit and Hyperactivity Disorder Self-report Screening Scale for DSM-5, Adult Attention Deficit and Hyperactivity Disorder Self-Report Scale Symptoms Checklist, Patient Health Questionnaire-9, and State-Trait Anxiety Inventory were applied. Results: Ninety patients and 40 healthy controls participated. Patients did not differ from controls in COVID-19 infection and vaccine status, and behavioral avoidance of COVID-19. No demographic and clinical factor significantly affected the COVID-19 infection status. Patients scored higher than controls in the perception of COVID-19 as contagious (p = 0.038), cognitive avoidance of COVID-19 (p = 0.008), and positive attitudes toward the COVID-19 vaccine (p = 0.024). After adjustment of possible factors, a positive perception of the COVID-19 vaccine and a perception of COVID-19 as dangerous were the two factors significantly affecting behavioral avoidance of COVID-19 [R 2 = 0. 17, F(2) = 13.189, p < 0.0001]. Conclusion: Infection and vaccine status of COVID-19 in patients did not significantly differ from controls. No demographic and clinical factor significantly affected the COVID-19 infection status. Approximately four-fifths of the patients were fully vaccinated as recommended by national and global health organizations. This has increased the knowledge base showing that the COVID-19 vaccine is acceptable and receiving the vaccine is endorsed by ADHD patients. Attention deficit and hyperactivity disorder itself may provoke no kind of mental disturbance in sense of perception of the danger of this disease. Our findings have increased the knowledge base showing that the COVID-19 vaccine is acceptable and the actual practice of receiving the vaccine is endorsed in this population. Our message for practice would be to take into account not only the core symptoms and the comorbidities of the disorder but also the perception of the disease while exploring its link with COVID-19.Publication Metadata only CHILDHOOD TRAUMA, DISSOCIATION IN PATIENTS WITH FIBROMYALGIA AND RHEUMATOID ARTHRITIS(2011-01-01T00:00:00Z) KILIÇ, ÖZGE; Taycan, O.; Poyraz, C. Aksoy; EROL, Tarık; Tecer, O.; Emul, H. M.; Sar, V.; Ozmen, M.; KILIÇ, ÖZGEPublication Open Access Assessment of loneliness in patients with inflammatory arthritis(2020-12-01T00:00:00Z) Emmungil, Hakan; Ilgen, Ufuk; Turan, Sezin; KILIÇ, ÖZGE; KILIÇ, ÖZGEAim: This study aimed to explore loneliness and associated factors in Turkish patients with inflammatory arthritis. Method: Adult patients with rheumatoid arthritis (RA) (n = 58), ankylosing spondylitis (AS) (n = 53), and psoriatic arthritis (PsA) (n = 30), respectively, were included in the study. A single-item visual analog scale (VAS) for loneliness, UCLA Loneliness Scale-8 (ULS-8), Beck depression inventory (BDI), Beck anxiety inventory (BAI), revised multidimensional scale of perceived social support, Health Assessment Questionnaire-Disability Index (HAQ-DI) were used for the psychometric and functional assessments. Multiple regression models were generated for predicting the ULS-8 and HAQ-DI scores. Results: There was no difference between disease groups in terms of the ULS-8 and HAQ-DI scores. Among demographic and clinical parameters, only the education status and number of drugs used had associations with the ULS-8 score. Single-item VAS score for loneliness did not predict the ULS-8 score well. There were significant correlations between the ULS-8 and HAQ-DI, depression, anxiety, social support, and physician global VAS scores. Only the education status significantly predicted (β = -0.208) the ULS-8 score in multiple regression analysis (adjusted R2 = 0.15, P < .001). Beck depression, anxiety, and patient global VAS scores remained significant for predicting the HAQ-DI after multiple regression with the covariates ULS-8, depression, anxiety, social support, patient and physician global VAS scores, and the number of drugs used (adjusted R2 = 0.53, P < .001). Disease activity and the ULS-8 scores were not found to be associated in any disease group. Conclusion: Loneliness is associated with depression, anxiety, lack of social support, disability, higher number of drugs used, and lower education but not with disease activity in Turkish patients with RA, AS, and PsA. Perception and expression of loneliness vary according to the cultural background. Single-item scales for loneliness may lack reliability compared to the more comprehensive ULS-8. Keywords: ankylosing spondylitis; inflammatory arthritis; loneliness; psoriatic arthritis; rheumatoid arthritis; social support.Publication Metadata only Ictal kissing behavior: Neurological and psychodynamic overview(2013-11-01T00:00:00Z) TAŞKIRAN, Emine; Ozmen, Mine; Kilic, ÖZGE; Senturk, Asli; ÖZKARA, Çiğdem; KILIÇ, ÖZGEThis study is based on the psychodynamic and neurological analysis of three Turkish patients who displayed ictal kissing automatism during their seizures. To unveil the probable underlying causes of their kissing behaviors, all patients underwent psychiatric interviews after being evaluated by ictal video-EEG recordings. The group consisted of two females (ages 35 and 29) and one male (age 26). In addition to prominent oral automatisms, each patient also displayed behaviors of kissing or blowing kisses to individuals at close proximity. Seizures were related to the right temporal lobe in two patients and the left temporal lobe in one patient. Magnetic resonance imaging showed mesial temporal sclerosis in two of the patients (one left, one right) and was normal in one. According to the DSM-IV-TR criteria, each of the three patients also suffered from major depression, while the psychodynamic interviews revealed traumatic childhood histories and intense unfulfilled affective needs. (C) 2013 Elsevier Inc. All rights reserved.Publication Metadata only A META-ANALYSIS OF ANXIETY DISORDER COMORBIDITY IN PEDIATRIC BIPOLAR DISORDER(2016-10-01T00:00:00Z) Taskiran, Sarper; Yapici-Eser, Hale; Mutluer, Tuba; Kilic, ÖZGE; Ozcan, Aslihan; Necef, Isil; Yalcinay, Merve; Ongur, Dost; KILIÇ, ÖZGEPublication Metadata only Risk and protective factors for mental disorders with onset in childhood/adolescence: An umbrella review of published meta-analyses of observational longitudinal studies(2020-01-01T00:00:00Z) Solmi, Marco; Dragioti, Elena; Arango, Celso; Radua, Joaquim; Ostinelli, Edoardo; KILIÇ, ÖZGE; Yilmaz, Ugur Eser; Yalcinay-İnan, Merve; Soares, Fernanda Cunha; Mariano, Luca; Mosillo, Pierluca; Cortese, Samuele; Correll, Christoph U.; Carvalho, Andre F.; Shin, Jae Il; Fusar-Poli, Paolo; KILIÇ, ÖZGE© 2020 Elsevier LtdThe patho-etiology of mental disorders with onset in childhood or adolescence remains largely unknown. We conducted an umbrella review of meta-analyses (MAs) on environmental factors associated with mental disorders with onset in childhood/adolescence. We searched Pubmed-MEDLINE/EMBASE/PsycInfo databases, last search April 29th, 2020. Quality of MAs was measured with AMSTAR-2. Out of 6851 initial references, ten articles met inclusion criteria, providing 23 associations between 12 potential environmental factors and nine disorders (cases: 8884; N = 3,660,670). While almost half of the associations were nominally significant, none of them met criteria from either convincing or highly suggestive evidence. A single association was supported by suggestive evidence (maternal exposure to lithium or antipsychotics with neuromotor deficits), but it was affected by confounding by indication. Ten more associations had weak evidence, and 12 associations were not statistically significant. Quality of meta-analyses was rated as high in two, moderate in one, low in four, critically low in two, and not pertinent in one (individual participant data). Methodologically-sound research is needed in this field.Publication Metadata only Subjective cognitive assessments and N-back are not correlated, and they are differentially affected by anxiety and depression(2021-09-01T00:00:00Z) Yapici-Eser, Hale; Yalcinay-Inan, Merve; Kucuker, Mehmet Utku; Kilciksiz, Can Misel; Yilmaz, Sezen; Dincer, Neris; KILIÇ, ÖZGE; Ercan, Alaattin Cenk; AYDEMİR, ÖMER; KILIÇ, ÖZGECognitive function (CF) is a core feature related to all psychiatric disorders. However, self-report scales of CF (SRSC) may not always correlate with CF-s objective measures and may have different mediators. Tools to select for evaluating CF in diverse psychiatric populations and their determinants need to be studied. In this study, we aimed to assess the association of SRSC (Perceived Deficit Questionnaire-Depression (PDQ-D), and World Health Organization-s Adult Attention Deficit Hyperactivity Disorder Self-Report Scale (ASRS) and its inattentiveness subscale) with Letter-N-back as an objective measure of CF, and to analyze their association with psychopathology. Two hundred nine (131 nonclinical, and 78 clinical with a psychiatric diagnosis of ICD10 F31-39 [mood disorders excluding Bipolar I] or F40-F49 [neurotic, stress-related or psychosomatic disorder] categories) participants were evaluated with PDQ-D, ASRS, Beck Depression Inventory (BDI), and Beck-s Anxiety Inventory (BAI), and N-back. Both groups- data were included in the analysis. PDQ-D showed a small correlation with N-back scores, whereas ASRS showed no correlation. PDQ-D and ASRS showed a large correlation. Age and BAI scores significantly predicted both PDQ-D and ASRS, whereas the cognitive subscale of BDI predicted PDQ-D, but not ASRS. Only BAI scores predicted N-back results. The mediation model revealed that 2-back scores of N-back task directly affects PDQ-D scores, independent of BDI scores. However, the cognitive subscale of BDI moderated 2-back and PDQ-D association. On the contrary, BAI scores significantly mediated the association of 2-back scores with PDQ-D. The direct effect of 2-back scores in PDQ-D was insignificant in the mediation of BAI scores. Our study validates the discordance between SRSC and an objective measurement of CF. Anxiety may affect both self-report and objective measurement of CF, whereas depressive thought content may lead to higher cognitive dysfunction reports in nondemented participants.Publication Metadata only Tropicamide ophthalmic solution reduces clozapine-induced sialorrhea: a case report(2017-01-01T00:00:00Z) Kilic, ÖZGE; Ozturk, Mihrimah; Gozcelioglu, Evsen Ata; KILIÇ, ÖZGEClozapine-induced sialorrhea (CIS) is a common, treatment-limiting, and stigmatizing side effect. All systemic agents that are used for CIS may increase clozapine side effects such as blood pressure changes, constipation, or arrhythmias or may have a negative impact on cognition. Sublingual application of antimuscarinic medications might be a low side effect option for treatment of CIS. Our aim is to propose an off-label treatment option of tropicamide ophthalmic solution given orally via sublingual route for CIS and stimulate further examination. A 33-year-old male inpatient with schizophrenia had been on clozapine 800 mg and amisulpride 600 mg per day. His drooling was occasional and severe as drool dripped off his chin during the day and night. Tropicamide 1% (1 mg/ml) ophthalmic solution was applied orally via sublingual route 1-2 drops at each side of his mouth before going to bed as monotherapy for CIS. Wet area over the pillow, Visual Analogue Scale (VAS), Nocturnal Hypersalivation Rating Scale, the MOS 36-Item Short-Form Health Survey (SF-36), Udvalg for Kliniske Undersogelser Side Effect Rating Scale, the Scale for the Assessment of Negative Symptoms, and the Scale for the Assessment of Positive Symptoms were administered at baseline visit and at one-week intervals. No side effects were observed. On VAS, the patient rated his sialorrhea 5/7 at baseline, 4/7 after one 1 drop, and 3/7 after 2 drops. Nocturnal hypersalivation yielded score 4 before tropicamide was initiated. After 1 drop of tropicamide at each side of the mouth, the score was 3 and after 2 drops at each side, it was 2. Tropicamide ophthalmic solution might present as a low side effect, off-label option for treatment of CIS. The promising effect should be examined by randomized controlled trials to translate this into clinical practice.