Person: BAŞARANOĞLU, METİN
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Publication Metadata only Dietary trans-fatty acid induced NASH is normalized following loss of trans-fatty acids from hepatic lipid pools.(2012-10-01T00:00:00Z) Neuschwander-Tetri, BA; Ford, DA; Acharya, S; Gilkey, G; Basaranoglu, METİN; Tetri, LH; Brunt, EM; BAŞARANOĞLU, METİNPublication Open Access Ovaries are more vulnerable than hepatocytes for insulin resistance and hyperinsulinemia(2016-01-01) GULTEPE, Ilhami; Basaranoglu, METİN; SULEYMANOGLU, Yaser; Basaranoglu, GÖKÇEN; BEYAZIT, Fatma; BAŞARANOĞLU, METİN; BAŞARANOĞLU, GÖKÇENBackground/Aims: Non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) are common metabolic disorders. We aimed to evaluate the underlying mechanisms in the development of NAFLD and PCOS.Publication Open Access Role of Discipline and Educational Method on Vocational High School Students- Success in an Anesthesia Course(2015-04-01) Basaranoglu, GÖKÇEN; Basaranoglu, METİN; BAŞARANOĞLU, GÖKÇEN; BAŞARANOĞLU, METİNObjective: The goal of this study is to reveal the relationship between discipline and teaching method and between vocational high school technical students' success in an anesthesia course and levels of following the lessons. Methods: A questionnaire was filled out by first-year technical students in an anesthesia course for situational awareness evaluation at the beginning of the term. Oral presentations were supported by catechetics, reward systems, etc. to ensure active participation. Results: While the students' success rate was 91.9%, the dissatisfaction rate was 4%. The students stated that they were most satisfied (100%) with the rewarding part of the theoretical lessons. Conclusion: Anesthesiology requires discipline for achieving success. Students' course success on anesthesia can be enhanced using a student-centered learning and reward system.Publication Open Access Rate and Predictors of Endoscopic Mucosal Healing in Biologic Naive Patients with Inflammatory Bowel Disease by Azathioprine Treatment: A Real World, 10 Years- Experience from a Single Centre in Turkey.(2016-08-01T00:00:00Z) Basaranoglu, METİN; Ertan, A; Mathew, S; Senturk, H; Ala, A; Demirbag, AE; BAŞARANOĞLU, METİN; ŞENTÜRK, HAKANBackground: There is increasing evidence that endoscopic mucosal healing (EMH) is a key target in inflammatory bowel disease (IBD) therapy. However, there is limited evidence of EMH rates with conventional IBD therapy outside of Western population groups. Ai̇m: To evaluate the role of azathioprine (AZA) in inducing EMH in IBD patients. Methods: Patients with inflammatory bowel disease were evaluated in terms of endoscopic mucosal healing and the incidence of surgical interventions during the azathioprine treatment between 1995 to 2014. Results: A total of 120 inflammatory bowel disease patients were enrolled. Endoscopic mucosal healing was found in 37% patients with inflammatory bowel disease (42% in chronic ulcerative colitis and 33% in Crohn's disease). Male gender had a negative impact on the efficacy of azathioprine (P<0.05). Responder inflammatory bowel disease patients were older (age at the IBD diagnose) than the nonresponder (P<0.05). Azathioprine therapy reduced the number of the surgical interventions (P<0.05). Conclusi̇on: We showed that azathioprine therapy significantly induced endoscopic mucosal healing in biologic naïve patients with active inflammatory bowel disease as well as decreasing the surgical interventions, with negative predictive factors identified by a younger age at IBD presentation and male gender.Publication Metadata only Two cases with Plummer-Vinson syndrome in the 21st century(2016-01-01) GULTEPE, Ilhami; Basaranoglu, METİN; BAŞARANOĞLU, METİNPlummer-Vinson syndrome (PVS) is characterized by the presence of postcricoid dysphagia, iron deficiency anemia, and upper esophageal web. This syndrome is now a rare condition because of the improvement in nutritional status and increased awareness regarding iron deficiency anemia and the early diagnosis and easy treatment of this anemia or underlying causes. In this presentation, we report two middle-aged female patients with PVS and briefly review the literature.Publication Open Access From fatty liver to fibrosis: A tale of -second hit-(2013-02-28) Basaranoglu, METİN; Basaranoglu, GÖKÇEN; Senturk, HAKAN; BAŞARANOĞLU, METİN; BAŞARANOĞLU, GÖKÇEN; ŞENTÜRK, HAKANAlthough much is known about how fat accumulates in the liver, much remains unknown about how this causes sustained hepatocellular injury. The consequences of injury are recognized as nonalcoholic steatohepatitis (NASH) and progressive fibrosis. The accumulation of fat within the hepatocytes sensitizes the liver to injury from a variety of causes and the regenerative capacity of a fatty liver is impaired. An additional stressor is sometimes referred to as a “second hit” in a paradigm that identifies the accumulation of fat as the “first hit”. Possible candidates for the second hit include increased oxidative stress, lipid peroxidation and release of toxic products such as malondialdehyde and 4-hydroxynonenal, decreased antioxidants, adipocytokines, transforming growth factor (TGF)-β, Fas ligand, mitochondrial dysfunction, fatty acid oxidation by CYPs (CYP 2E1, 4A10 and 4A14), and peroxisomes, excess iron, small intestinal bacterial overgrowth, and the generation of gut-derived toxins such as lipopolysaccharide and ethanol. Oxidative stress is one of the most popular proposed mechanisms of hepatocellular injury. Previous studies have specifically observed increased plasma and tissue levels of oxidative stress markers and lipid peroxidation products, with reduced hepatic and plasma levels of antioxidants. There is also some indirect evidence of the benefit of antioxidants such as vitamin E, S-adenosylmethionine, betaine, phlebotomy to remove iron, and N-acetylcysteine in NASH. However, a causal relationship or a pathogenic link between NASH and oxidative stress has not been established so far. A number of sources of increased reactive oxygen species production have been established in NASH that include proinflammatory cytokines such as tumor necrosis factor (TNF)-α, iron overload, overburdened and dysfunctional mitochondria, CYPs, and peroxisomes. Briefly, the pathogenesis of NASH is multifactorial and excess intracellular fatty acids, oxidant stress, ATP depletion, and mitochondrial dysfunction are important causes of hepatocellular injury in the steatotic liver.Publication Metadata only Diagnostic yield of colonoscopic images and biopsy Results by tuberculosis culture (solid and liquid) in patients with intestinal ulceration(2015-02-01T00:00:00Z) Basaranoglu, METİN; COSKUN, O.; YUKSEL, M.; KAPLAN, M.; AKSOY, A.; UCARMAN, N.; TURHAN, N.; ARSLANTURK, A.; BAŞARANOĞLU, METİNPublication Metadata only Nonalcoholic fatty liver may increase the risk of operation in patients with fatty liver and the frequency of cancer in their first-degree relatives(2016-10-01) Basaranoglu, METİN; CANBAKAN, Billur; YILDIZ, Kemal; CEYLAN, Bahadir; BAYSAL, Birol; Uysal, Omer; Senturk, HAKAN; BAŞARANOĞLU, METİN; UYSAL, ÖMER; ŞENTÜRK, HAKANFatty liver is a common disease in developed countries. We investigated the frequency of operation in patients with fatty liver and the frequency of cancer in their first-degree relatives.Publication Metadata only The utility of amylase and lipase as reliable predictive markers for functioning renal graft.(2012-07-01T00:00:00Z) Yilmaz, UE; Yilmaz, N; Titiz, I; Basaranoglu, METİN; Tarcin, O; BAŞARANOĞLU, METİNPublication Metadata only Low lipase levels as an independent marker of pancreatic cancer: a frequently neglected condition in clinical setting(2016-03-01) GULTEPE, Ilhami; Basaranoglu, METİN; Zorlu, MEHMET; SENYIGIT, Abdulhalim; TASKALE, Emine Zeynep; ZARALI, Sibel; Atay, Kadri; KOROGLU, Emine; BAŞARANOĞLU, METİN; ZORLU, MEHMETBackground/Aims: Low lipase levels, which may be an indication of low production due to organ failure, are frequently encountered in a clinical setting, but are usually overlooked. This study examined the values of low serum lipase levels and other clinical parameters in the diagnosis of several clinical conditions, such as in pancreatic cancer.
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