Person: GÜCİN, ZÜHAL
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Publication Metadata only p53 expression and relationship with MDM2 amplification in breast carcinomas(2016-04-01) Buyukpinarbasili, NUR; Gucin, ZÜHAL; Ersoy, YELİZ EMİNE; ILBAK, Ayca; Kadioglu, HÜSEYİN; Muslumanoglu, Mahmut; BÜYÜKPINARBAŞILI, NUR; GÜCİN, ZÜHAL; ERSOY, YELIZ EMINE; KADIOĞLU, HÜSEYİNCarcinoma of the breast, like other malignancies, is a genetic disease with multiple genetic events leading to the malignant phenotype. p53 mutations are the most common genetic events in human cancer. Inactivation of p53 can be a result of mutation in gene sequence. One of the main structures that regulate p53 stabilization is MDM2. It suppresses p53 transcriptional activation by recognizing transactivation domain of p53. The loss of MDM2 function on p53 regulation results in deprivation of p53 tumor suppressor ability. Single nucleotide polymorphisms (SNP309 T->G exchange) or MDM2 amplification has been proposed to play a role in this issue. In the present study, our aim is to analyze p53 and MDM2 status and investigate their interactions in human sporadic breast carcinoma. The study groups were separated according to their molecular classifications. In each group, histologic type of the tumor, conventional prognostic parameters, p53, and MDM2 interactions were compared statistically. Tumors are divided into 4 subtypes due to estrogen and progesterone receptor status, HER-2, and Ki-67 proliferation index results. According to this classification, 23 cases are in the luminal A, 32 cases are in the luminal B, 15 cases are in the HER-2 positive, and 22 cases are in the triple-negative group, with a total of 92 cases. p53 expression is low in luminal breast carcinomas than HER-2 and triple-negative subtypes. MDM2 amplification frequency was found to be 5.4% in total. MDM2 gene amplification does not have a significant role in breast carcinogenesis, but other possible mechanisms may play a role in its inactivation. (C) 2016 Elsevier Inc. All rights reserved.Publication Metadata only Assessment of multifocality and axillary nodal involvement in early-stage breast cancer patients using 18F-FDG PET/CT compared to contrast-enhanced and diffusion-weighted magnetic resonance imaging and sentinel node biopsy(2015-08-01) ERGÜL, Nurhan; Kadioglu, HÜSEYİN; Yildiz, Seyma; YUCEL, Serap Baskaya; Gucin, ZÜHAL; Erdogan, EZGİ BAŞAK; Aydin, MEHMET; MUSLUMANOGLU, Mahmut; KADIOĞLU, HÜSEYİN; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; ERDOĞAN, EZGİ BAŞAK; AYDIN, MEHMETBackground: Non-invasive evaluation of the extent of axillary nodal involvement in early-stage breast cancer (ESBC) patients and accurate assessment of multifocality are both challenging. Few reports have explored whether 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) might be more useful than other diagnostic methods in these contexts.Publication Metadata only Skin Recurrence of a Phylloides Tumor and Impacy of Radiotherapy A Case Report and Review of The Literature(2013-01-01) YÜCEL, SERAP; KADIOĞLU, HÜSEYİN; GÜRAL, ZEYNEP; YILDIZ, ŞEYMA; YILDIZ, ŞEYMA; GÜCİN, ZÜHALPublication Metadata only Primer Meme Lenfoması; Yineleyen Hastalık,(2012-05-01) KADIOGLU, HÜSEYİN; YUCEL, SERAP BASKAYA; GÜRAL, ZEYNEP; GÖZÜBÜYÜKOGLU, NURHAN; AKGÜN, ZÜLEYHA; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; BOZKURT, SÜLEYMAN; ERSOY, YELİZ EMİNE; SAGLAM, ESRA KAYTAN; KADIOĞLU, HÜSEYİN; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; BOZKURT, SÜLEYMANPublication Metadata only İNFLAMATUAR MEME KANSERİ ŞEKLİNDE PREZENTE OLAN MÜSİNÖZ MEME KANSERİ OLGUSU(2015-08-01) YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; ERDOĞAN, EZGİ BAŞAK; KADIOĞLU, HÜSEYİN; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; ERDOĞAN, EZGİ BAŞAK; KADIOĞLU, HÜSEYİNPublication Metadata only Primary breast lymphoma; disease recurrence(2012-09-01) KADIOĞLU, HÜSEYİN; YUCEL, SERAP; GÜRAL, ZEYNEP; GÖZÜBÜYÜKOGLU, NURHAN; AKGÜN, ZÜLEYHA; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; BOZKURT, SÜLEYMAN; ERSOY, YELİZ EMİNE; MUSLUMANOGLU, MAHMUT; SAGLAM, ESRA KAYTAN; KADIOĞLU, HÜSEYİN; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; BOZKURT, SÜLEYMANPublication Metadata only Comment on: Actinomycotic Infection of the Abdominal Wall Mimicking a Malignant Neoplasm by Yi et al.(2012-12-01) Kadioglu, HÜSEYİN; Ersoy, YELİZ EMİNE; Bozkurt, SÜLEYMAN; Memmi, NAİM; CIPE, Gokhan; Gucin, ZÜHAL; MUSLUMANOGLU, Mahmut; KADIOĞLU, HÜSEYİN; ERSOY, YELIZ EMINE; BOZKURT, SÜLEYMAN; MEMMİ, NAİM; GÜCİN, ZÜHALPublication Open Access The role of PET and MRI in evaluating the feasibility of skin-sparing mastectomy following neoadjuvant therapy.(2018-02-01) MALYA, FATMA ÜMİT; KADIOGLU, HÜSEYİN; BEKTASOGLU, HÜSEYİN KAZIM; Gucin, ZÜHAL; YILDIZ, S; GUZEL, MEHMET; ERDOGAN, EZGİ BAŞAK; YUCEL, S; ERSOY, YELİZ EMİNE; MALYA, FATMA ÜMİT; KADIOĞLU, HÜSEYİN; BEKTAŞOĞLU, HÜSEYİN KAZIM; GÜCİN, ZÜHAL; YILDIZ, ŞEYMA; GÜZEL, MEHMET; ERDOĞAN, EZGİ BAŞAK; ERSOY, YELIZ EMINEAbstract Objective: To investigate the role of positron emission tomography (PET) and magnetic resonance imaging (MRI) in evaluating the feasibility of skin-sparing mastectomy in patients with locally-advanced breast cancer (LABC) who will undergo neoadjuvant chemotherapy (NAC) by evaluating the sensitivity and specificity of PET and MRI compared with skin biopsy results before and after NAC treatment. Methods: Patients with LABC who were treated with NAC between November 2013 and November 2015 were included in this study. Demographic, clinical, radiological and histopathological features of the patients were recorded. Results: A total of 30 patients were included in the study with a mean age of 52.6 years (range, 35– 70 years). Sensitivity and specificity for detecting skin involvement in LABC was 100%/10% (62%/ 85%) with MRI and 60%/80% (12%/92%) with PET before (after) NAC, respectively. When radiological skin involvement was assessed in relation to the final histopathological results, the preNAC PET results and histopathological skin involvement were not significantly different; and there was no difference between postNAC MRI and histopathological skin involvement. Conclusions: As preNAC PET and postNAC MRI more accurately determined skin involvement, it might be possible to use these two radiological evaluation methods together to assess patient suitability for skin-sparing mastectomy in selected patients.Publication Metadata only Primary breast lymphoma; disease recurrence Primer meme lenfomasi{dotless}; yineleyen hastali{dotless}k(2012-09-18) Kadioǧlu, HÜSEYİN; YUCEL, Serap; GÜRAL, Zeynep; GÖZÜBÜYÜKOGLU, Nurhan; AKGÜN, Züleyha; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; Bozkurt, SÜLEYMAN; ERSOY, YELİZ EMİNE; MUSLUMANOGLU, Mahmut; SAGLAM, Esra Kaytan; KADIOĞLU, HÜSEYİN; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; BOZKURT, SÜLEYMAN; ERSOY, YELIZ EMINEPublication Metadata only Skin Recurrence of a Phyllodes Tumor and Impact of Radiotherapy: A Case Report and Review of the Literature.(2013-01-01T00:00:00Z) KADIOĞLU, HÜSEYİN; YÜCEL, SERAP; GÜRAL, ZEYNEP; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL; YILDIZ, ŞEYMA; GÜCİN, ZÜHAL